Histo Review Flashcards
1
Q
3 major groups of hematopoetic growth factors
A
- CSF: GM-CSF, G-CSF and M-CSF
- EPO/TPO
- Interleukins and cytokins
2
Q
M-CSF
A
macrophage- CSF
3
Q
G-CSF
A
granocyte-CSF
Neutrophils NEED
4
Q
GM-CSF
A
granulocyte-monocyte- CSF
5
Q
What are the lineage restrictive progenitors CMP develops into?
A
- GMP and
2. MEP
6
Q
What secretes EPO
A
Kidney
7
Q
CMP–> MEP is influenced by what cytokines?
A
EPO
IL3
IL4
8
Q
When can a red blood cell no longer divide?
A
Orthochromatophilic erythroblast; it begins to shed nucleus and go to the sinusoid
9
Q
What influences differentiatio of MEP–> MKP?
A
GM-CSF
IL3
10
Q
GMPs need what interleukins?
A
GM-CSF
IL3
11
Q
EoP needs what interleukins
A
GM-CSF
IL3
IL5
12
Q
Basophils need what interleukins
A
GM-CSF
IL3
13
Q
What in granulopoiesis first starts to make granules
A
Promyelocyte
14
Q
What in granulopeosis starts to make specific granules
A
Myelocyte
15
Q
Monocyte transformation takes how long?
A
55 hours
