Review

Question 1

Phosphogen system- time frame and substrate

Answer 1

7-9s

creatine phosphate

Question 2

How is creatine phosphate transferred into the cell

Answer 2

Creatine kinase can phosphorylate creatine phosphate in the cytosine of the cell and make it into a high energy molecule (CrP)

-CrP then diffuses across the cell membrane into the mm cell where it is broken down and releases phosphate

Question 3

what is the phosphates system limited by

Answer 3

limited by the rate that creatine can diffuse back into the cytosol and be synthesized back into creatine phosphate (2-3misn)

Question 4

Krebs cycle nutrient utilization at 30, 50, 80% VO2max

Answer 4

30- free fatty acids
50- glucose and free fatty acids
80- glucose

Question 5

In terms of weight management what vo2 max do u wanna be at

Answer 5

fat burning zone

-more free fatty acids are mobilized at 50% vo2max but total energy output is lower so have to increase duration

Question 6

What is a key enzyme involved in cardiovascular disease

Answer 6

CoQ10 (HMG-CoA reductase is an enzyme responsivle for synthesis of coQ10)

Question 7

What is the mTOR pathway used for

Answer 7

Angiogenesis, tumor formation, insulin resistance, adipogenesis

Question 8

5 components of mTOR to function

Answer 8

1. mTOR and regulator associated pro
2. mLSt8
3. DEPTOR (interacting pro)
4. FKB38
5. PRAS40 (proline rich AKT substrate)

Question 9

5 functions of mTOR complex

Answer 9

1. master regulator of growth + metabolism
2. Synthesis + organization of microtubules
3. Autophagy
4. Lipid syntheisis
5. mitochondrial biogenesis

Question 10

What med blocks mTOR function

Answer 10

rapamycin

Question 11

Key things to optimize mTOR pathway

Answer 11

• increase glucose and insulin by consuming pro
• decrease substrate and shuttle glucose thru glut4
• decrease ATP:ADP ratio
• decrease ox
• increase TNF-alpha

Question 12

how many ATP can be yielded assuming malate shiuttle is not used

Answer 12

36