Reversible Cell Injury Flashcards
What is Acute cell swelling?
An early, sub-lethal manifestation of cell damage, characterized by increased cell size and volume.
What is another name for Acute cell swelling?
Hydropic Degeneration
What is the most common and fundamental expression of cell injury?
Acute cell Swelling AKA Hydropic Degeneration
What happens in Hydropic Degeneration?
overload of intracellular water, can see intracytoplasmic vacolation, reflects alterations in electrolyte transport across plasma membrane and endoplasmic reticulum (electrolyte imbalance)
What is the Gross appearance of hydorpic degeneration
Organ is slightly swollen, rounded edges, paler than normal,
What is the histological appearance of hydorpic degeneration?
Affected cells appear enlarged with pale cytoplasm, nucleus is often in its normal postion
What is hydropic degeneration?
swell due to increased uptake of water and diffuse disintegration of organelles and cytoplasmic proteins
Where does fatty change take place?
Occurs in cells that participate in fat metabolism (hepatocytes), cardiomyocytes, renal tubular epithelium
What is “fatty change”?
in early stages it is a sub-lethal cell damage characterized by intracytoplasmic fatty vacuolation.
what is the pathogensis of a fatty change?
impaired metabolism of fatty acids, accumulation of triglycerides- results in intracytoplasmic fat vacuoles.
What is the Etiology of fatty change?
Occurs in various forms of injury - main causes are hypoxia, toxicity, and metabolic disorders.
seen in abnormalities of synthesis, utilization and export of fat.
what is lipodsis?
accumalation of triglycerides and other lipis metabolities ( neutral fats and cholesterol) within the cytolosol of parenchymal cells, packaged in the VLDL fraction
what special stains are used to diagnose fat?
frozen cross sections and lipid soluble dyes “oil red O” sudan 3 and 4.
