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Pathology > Necrosis > Flashcards

Necrosis Flashcards

1
Q

What is Necrosis?

A

termed used to describe the range of morphological changes that occur following cell death in the living animal.

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2
Q

the morphological appearance of necrosis is due to what?

A

Denaturation of proteins
Enzyme digestion of the cell
end result is inflammation

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3
Q

What does Karolysis mean?

A

nuclear fading, chromatin dissolution due to action of DNAases and RNAases

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4
Q

What is pyknosis?

A

Nuclear Shrinking

DNA condenses into shrunken basophilic (purple) mass

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5
Q

What is Karyorrhexis?

A

Nuclear fragmentation

Pyknotic nuclei membrane ruptures and nucleus undergoes fragmentation

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6
Q

Karyolysis, Pynosis, and karyorrhexis all lead to what?

A

Nuclear dissolution then to Anuclear necrotic cell

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7
Q

What is coagulative necrosis?

A

form in which the dead tissue is perserved for days, affected tissue is firm.

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8
Q

what is coagulative necrosis caused by?

A

caused commonly by ischemia in all solid organs except the brain.

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9
Q

what is an infarct?

A

a localized area of coagulative necrosis- ischemia necrosis infarcts can appear white.

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10
Q

what is liquefactive necrosis?

A

dead cells are digested- resulting in transformation of the tissue into a liquid mass.

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11
Q

what happens in liquefactive necrosis?

A

microbes stimulate the accumulation of WBCs and liberation of enzymes from these cells

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12
Q

what does malacia mean

A

softening of the tissue

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13
Q

what does polio mean?

A

grey matter

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14
Q

what is myliomalacia?

A

softening of the spinal cord

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15
Q

liquidofactive necrosis is always in the?

A

CNS

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16
Q

in a histology off liquidofactive necrosis there is ?

A

loss of cellular detail, cannot tell the tissue type

17
Q

difference between liquiofactive necrosis and an abscess

A

Abscess is surrounded by a fibrous capsule layer chronic

result of bodies defensive rxn to foreign material

18
Q

what is the most common cause of pyogenic (pus) abscess?

A

staph and strep

19
Q

What is caseous necrosis?

A

chronic necrosis, Cheeselike, crumble, necrotic due to dead WBC
myco, and coryne and fuso bact along with fungal

20
Q

What is Dry Gangrenous Necrosis?

A

no bacterial superinfection

21
Q

How does gangrenous necrosis begin

A

begins mostly as coagulative necrosis, likely due to ischemia

22
Q

What is Wet Gangrenous necrosis?

A

bacterial superinfection, tissue looks wet and liquiofactive

23
Q

what does the dark color come from in wet gang green?

A

bursting RBC and release of hemoglobin

24
Q

what is the color from in dry gang green?

A

black, post mortem change although attached to a live animal

25
Q

What is enzymatic necrosis of fat?

A

Pancreatic necrosis, looks white like soap

26
Q

What is tramatic necrosis of fat?

A

tend to mineralize and get really hard, dystosia, subQ sternum in recumbent cattle

27
Q

Necrosis of abdominal fat in cattle

A

idopathic (dont know cause)

Jersey and Guernesy most common (channel island breeds)

28
Q

What is Fibroid necrosis?

A

special form of necrosis typically seen in immune reactions involving blood vessels.
Ag-Ab complexes are deposition in the walls of arteries

29
Q

what is a cause of fibroid necrosis?

A

Viral, bacT Dz infection inducing inflammation for too long - forming immune complexes

30
Q

Cell size in necrosis

A

enlarged

31
Q

nucleus in necrosis

A

Pykinosis > Karyorrhexis > karyolysis

32
Q

Plasma membrane in necrosis

A

Disrupted

33
Q

Cellular contents in necrosis

A

enzymatic digestion, may leak out of cell

34
Q

adjacent inflammation of necrosis

A

frequent

35
Q

physiological or pathologic role of necrosis

A

invariably pathological (culmination of irreversible cell injury)

Pathology (9 decks)

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