Apoptosis

Question 1

The intrinsic pathway of apoptosis is known as the

Answer 1

mitocondrial pathway

Question 2

the initator caspases in the intrinsic pathway is?

Answer 2

Caspase-9

Question 3

the extrinsic pathway of apoptosis is known as the

Answer 3

death receptor pathway

Question 4

the initiation capase in the extrisic pathway is?

Answer 4

caspase-8

Question 5

What are the major inducers of apoptosis?

Answer 5

Withdrawal of growth factors / hormones
Injury (rad,tox,Free rad)
Receptor- ligand interactions (Fas,TNF)
Cytotoxic T- Lymphocytes

Question 6

what are the regulators of apoptosis?

Answer 6

Bcl-2 family members and Mcl-1

Question 7

What are the Executioner capases?

Answer 7

both pathways is Capases 3 and 6

Question 8

what is the major mechansim of apoptosis in mammalian cells?

Answer 8

Intrinsic

Question 9

what does cytochrome-c do?

Answer 9

released into cytoplasm., initiates suicide program of apoptosis.
controlled releases by pro and anti apoptoic members of the Bcl family

Question 10

what are the pro- apoptotic proteins?

Answer 10

Bim,Bid,Bad Bh3

Bak Bax

Question 11

the Extrinsic pathway is initiated by

Answer 11

death receptors
members of the TNF family
TNF, TNFR1, FAS CD95

Question 12

Cell size in Apoptosis?

Answer 12

Reduced

Question 13

Nucleus in apoptosis?

Answer 13

Fragmentation into nuclesome- size fragments

Question 14

Plasma membrane in apoptosis

Answer 14

intact, altered structure esp orientation of lipids

Question 15

Cellular contents in apoptosis?

Answer 15

intact, maybe be released in apoptotic bodies

Question 16

Adjacent inflammation in apoptosis

Answer 16

no inflamation

Question 17

physiologic or pathologic role

Answer 17

often physiologic, means unwanted cells may be pathologic after some forms of cell injury esp DNA damage