Reversals/Anticholinergics

Question 1

Edrophonium

1. MOA
2. E 1/2t
3. PharmK
4. SE
5. Contraindications
6. Dose

Answer 1

0.5 - 0.75 mg/kg (w/ Atropine 0.01mg/kg)

Question 2

Neostigmine

1. MOA
2. E 1/2t
3. PharmK
4. SE
5. Contraindications
6. Dose

Answer 2

0.05 - 0.07 mg/kg (w/ Glyco 0.01-0.02 mg/kg)

Question 3

Pyridostigmine

1. MOA
2. E 1/2t
3. PharmK
4. SE
5. Contraindications
6. Dose

Answer 3

0.14 - 0.25 mg/kg (w/ Glyco 0.01-0.02 mg/kg)

Question 4

Physostigmine

1. MOA
2. E 1/2t
3. PharmK
4. SE
5. Contraindications
6. Dose

Answer 4

0.5 mg/kg q 1-2hrs

Question 5

Sugammadex

1. MOA
2. E 1/2t
3. PharmK
4. SE
5. Contraindications
6. Dose

Answer 5

2 mg/kg (1-2 PRE-tetanic twitches)
4 mg/kg (1-2 POST-tetanic twitches)
16 mg/kg (emergent reversal)

Question 6

Atropine

1. MOA
2. E 1/2t
3. PharmK
4. SE
5. Contraindications
6. Dose (Reversal/Bradycardia/Resuscitation/Bronchodilation)

Answer 6

Reversal: Physiostigmine 15-60 mcg/kg
Pre-op: 0.2-0.4 mg/kg
Bradycardia: 0.4-1 mg (Max 3mg)
Resuscitation: 1 mg q 3-5min
Bronchodilation: 2mg in 5ml Nebulizer

Question 7

Glycopyrrolate

1. MOA
2. E 1/2t
3. PharmK
4. SE
5. Contraindications
6. Dose (Anti-salagogue)

Answer 7

Reversal: Neostigmine 50-70 mcg/kg

Anti-salagogue: 0.1-0.2 mg

Question 8

Scopalamine

1. MOA
2. E 1/2t
3. PharmK
4. SE
5. Contraindications
6. Dose (Reversal/Transdermal)

Answer 8

Reversal: Physostigmine 15-60 mcg/kg
Transdermal: 1.5 mg