Retroviridae

Question 1

Retroviruses act by reverse transcriptase of

Answer 1

RNA-dep. DNA polymerase

Question 2

Retroviruses general

Answer 2

enveloped, spherical

diploid geome- two copies of (+), ssRNA

Question 3

Retroviruses replicate by

Answer 3

Reverse transcriptase

Question 4

Feline Leukaemia is a ___retrovirus

Answer 4

gammaretrovirus

Question 5

FeLV encodes for 3 genes

Answer 5

env, pol, gag

Question 6

T or F

FeLV is easily destroyed in the environment

Answer 6

True

and is readily destroyed by disinfectants, soap, heat, etc.

Question 7

FeLV: transmission

Answer 7

direct contact with saliva, nasal secretions, feces, milk, bites

Question 8

FeLV has a trophism for

Answer 8

Lymphoid tissue (oral and pharyngeal)
infects monocytes and lymphocytes

Question 9

FeLV: pathogenesis

Answer 9

Decreases T (CD4) cells- immunosuppression
wasting syndrome

Question 10

Main determinant for FeLV pathogenesis

Answer 10

SU protein- surface glycoprotein

Question 11

FeLV: CS

Answer 11

immunosuppression, regenerative(and non) anemia, lymphoma, leukaemia

Question 12

FeLV: diagnosis

Answer 12

p27 ELISA

IFA, virus isolation, PCR, Serology

Question 13

FeLV: control

Answer 13

vaccine, isolate + animals

Question 14

FIV is a ___virus

Answer 14

lentivirus

Question 15

About ___% of cats in the U.S. are infected with FIV

Answer 15

2.5%

Question 16

FIV replicates in (cells)

Answer 16

lymphocytes

Question 17

FIV: pathogenesis

Answer 17

infected lymphocytes - decrease in IL-2 prod. - lymphopenia

increased IL-10 prod. - immunosuppression

Question 18

FIV: transmission

Answer 18

bite, scratch

via birth canal

Question 19

FIV: CS

Answer 19

on and off persistent fever, loss of appetite, lethargy, gingivitis, stomatitis, bladder and upper resp. infection
diarrhea, wasting

Question 20

FIV: diagnosis

Answer 20

ELISA, immunoblotting, PCR

Question 21

FIV: control and treatment

Answer 21

vaccine, isolate infected

treat symptomatically

Question 22

retrovirus causes to distinct diseases in birds

Answer 22

Avian leucosis and sarcoma viruses- alpharetrovirus

Question 23

avian retroviruses: CS

Answer 23

lymphoid leukosis, tumors, nodular lesions of bursa fabricius

Question 24

AR: can cause osteoporosis of long bones called

Answer 24

Thick leg syndrome

Question 25

AR: erythroblastosis

Answer 25

presence of erythroblasts in blood- anemia, swollen liver and kidneys
cellular transformation of oncogeneic viruses

Question 26

A lentivirus in horses causes

Answer 26

Equine infectious anemia virus (Swamp fever)

Question 27

SF: transmission

Answer 27

mechanically, venerally, in utero, milk/colostrum

Question 28

SF: pathogenesis

Answer 28

infects monocytes/macrophages - phagocytosis/lysis of RBC-

anemia and thrombocytopenia

Question 29

SF: CS

Answer 29

Thrombocytopenia = petechiae hemo, edema
asymptomatic until stressed
anemia, lethargy, weightloss, fever, enlarged spleen, swollen belly/legs

Question 30

SF: diagnosis

Answer 30

AGID or Coggin’s test (may have false answers), ELISA, immunoblot