Restrictive pulm diseasesw

Question 1

Restrictive pulmonary disease

Answer 1

• reduced expansion of lung parenchyma
• decreased lung capacity
• decreased compliance
• reduction of both fev and fvc
• fvc is normal

Question 2

Idiopathic Pulmonary fibrosis

Answer 2

• Chronic, progrressive fibrosing of interlobular, subpleural lung, cobblestone pleural
• Cyclical lung injury
• 55 to 70
• rales with unknown onset
• tgfBETA
• transplant is only treatment
• Bleomycin and amidarone cause it as well as radiation therapy.

Question 3

Cryotogenic Organizing pneumonia

Answer 3

• Polyploid plugs of loose organizing connective tissue in the small airways, alveolar ducts
• surrounded by inflammation
• Treat with roids

Question 4

Pneumonconiosis: Asbestos

Answer 4

M* eats asbestos but cant degrade –>pleural plaques and effusions with parenchymal fibrosis
-Has golden brown beaded rods with translucent centers and iron coating
Crystal tile: more common less pathgoenic,
Amphibole: stiff and straight go into lungs.
-Greece or other exposure

Question 5

Pneumonconiosis: silicosis

Berilium is also a thing for aerospace people

Answer 5

• Inhaled silicon dioxide activates m*
• AA stone cutters
• Fibrotic nodule with increased susceptibility to TB

Question 6

Sarcoidosis :

Answer 6

• Cell mediated immune response to unknown insult
• Becomes non caseating granuloma with asteroid /Schaumann body especially in AA women.
• High ACE and calcium
• Eye and skin lesions occur
• CXR shows bilateral lymphadenopathy

Question 7

Pulmonary Langerhans cells histiocytosis/Eosinphilic granuloma

Answer 7

• Proliferation of Langerhans cell with eosinophils
• Tennis racket shaped birbeck granule
• Nodules on imaging
• Smoking adult
• Pneumothorax

Question 8

Pulmonary Alveolar Proteinosis: Cause

Answer 8

Accumulation of acellular surfactant in intra alveolar and bronchial spaces
-Autoimmine to anti GM-CSF –> loss of alveoli to catabolize surfactant

Question 9

Pulmonary Alveolar Proteinosis: Presentation

Answer 9

Granular material and histiocytes with alveolar
-Bilateral pathy asymmetric pulmonary OPACITY
-30-50 year old men
Treat with lung lavage

Question 10

Respiratory Bronchiolitis

Answer 10

• Accumlation of intra-alveolar M* leading to chronic inflammation of bronchioles in 30-40 year old smokers.
• Treat with roids
• CXR bilateral reticulonodular infiltrates with ground glass appearance