Resting membrane potential

Question 1

what is the typical membrane resting potential

Answer 1

-70 mV

Question 2

ICF value of potassium

Answer 2

140 mM

Question 3

ECF value of potassium

Answer 3

4 mM

Question 4

ICF value of sodium

Answer 4

15 mM

Question 5

ECF value of sodium

Answer 5

145 mM

Question 6

ICF value of calcium

Answer 6

<0.001 mM

Question 7

ECF value of calcium

Answer 7

1.8 mM

Question 8

ICF value of chlorine

Answer 8

4 mM

Question 9

ECF value of chlorine

Answer 9

115 mM

Question 10

definition of resting membrane potential

Answer 10

is the net difference of charge between the intracellular fluid and extracellular fluid at rest

result of unequal distribution of ions on each side of the membrane

usually negative (negative charge inside the cell)

Question 11

nernst equation

Answer 11

used to calculate equilibrium potential of an ion

if the membrane was only permeable to one type of ion, the membrane potential would be equal to the nernst potential for that ion

Eion = 61/z log [ion]out/[ion]in

Question 12

Goldman-Hodgkin-Katz Equation

Answer 12

predicts membrane potential that results from the contribution of all ions that can cross the membrane

Vm= 61 log (Pk[Kout]+Pna[na]out+Pcl[cl]in)/Pk[kin]+Pna[Nain]+Pcl[clout])

Question 13

which ion is the primary contributor to membrane potential in all cells

Answer 13

K+