Respiratory System Flashcards

1
Q

Respiration

A

O2 from lungs to tissues
CO2 from tissues to lungs

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2
Q

4 processes of respiration

A

1) pulmonary ventilation:
breathing, air in/out lungs
2) external resp: O2/CO2 lungs/blood
3) transport of resp gas: blood carrying O2/CO2 lungs/tissues
4) Internal resp: O2 blood/cells

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3
Q

Identify the organs forming the respiratory passageways in descending order

A

Sites of gas exchange.

respiratory bronchioles
alveolar ducts
alveoli.

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4
Q

Distinguish between conducting and respiratory zone structures.

A

conducting zones are external, leading to the internal respiratory zones

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5
Q

List and describe several protective mechanisms of the respiratory system

A

MALT system
Inflation Reflex (don’t overinflate)
Pleural cavity?

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6
Q

Describe the makeup of the respiratory membrane and relate structure to function.

A

alveoli: Type I epithelial cells overlaying thin basal lamina.
capillary: endothelial cells overlaying thin basal lamina.

Gasses diffuse
Soap prevents sticking

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7
Q

Describe the gross structure of the lungs and pleurae.

A

lungs are in plural cavity, right lung has 3 lobes, left has 2 lobes and cardiac notch.

pleurae is a thin membrane surrounding lungs and forming pleural cavity (visceral, pleural, parietal)

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8
Q

Relate Boyles law to events of inspiration and expiration.

A

if volume increases, pressure must decrease. If volume
decreases, pressure must increase

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9
Q

Explain the relative roles of the respiratory muscles and lung elasticity in producing the volume changes that cause air to flow into and out of the lungs.

A

diaphragm down, intercostal up on inhale

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10
Q

Explain the functional importance of the partial vacuum that exists in the intrapleural space.

A

Whether or not a lung will inflate or deflate depends on the Intrapulmonary and Intrapleural
pressures.

If Intrapulmonary pressure is greater than Intrapleural pressure, the lung inflates.

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11
Q

List several physical factors that influence pulmonary ventilation.

A

Airway resistance
alveolar surface tension: favors lung collapse
lung compliance

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12
Q

Indicate types of information that
can be gained from pulmonary function tests.

A

lung volumes
air flow
diffusion capacity

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13
Q

Define dead space.

A

the volume of air within the respiratory system that does not participate in gas exchange, like scarring and disease

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14
Q

State Daltons law of partial pressures

A

The total pressure exerted by a mixture of gases is the sum of the pressures exerted independently by each gas in the mixture.

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15
Q

State Henry’s Law

A

The solubility of a gas is related to the gas’s concentration.

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16
Q

Describe how atmospheric and alveolar air differ in composition and explain these differences.

A

Alveolar air has less oxygen, more carbon dioxide, and more water vapor than atmospheric air due to the processes of gas exchange, humidification, and mixing with residual lung air. These differences are crucial for maintaining efficient respiration and homeostasis in the body.

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17
Q

Relate Dalton’s and Henry’s laws to events of external and internal respiration.

A
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18
Q

Describe how oxygen is transported in the blood and explain how oxygen loading and unloading is affected by temperature, pH, 2,3-DPG, and PCO2.

A
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19
Q

Describe carbon dioxide transport in the blood.

A
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20
Q

Describe the neural controls of respiration.

A
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21
Q

Compare and contrast the influences of lung reflexes, volition, emotions, arterial pH, and arterial partial pressures of oxygen and carbon dioxide on respiratory rate and depth.

A
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22
Q

Compare and contrast the hypernea of exercise with involuntary hyperventilation.

A
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23
Q

Describe the process and effects of acclimatization to high altitude.

A
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24
Q

causes and consequences of chronic bronchitis

A

Excessive mucus, inflammation, fibrosis of respiratory zones caused by inhaled irritants. Frequent pulmonary infections.

thick membrane = less gas exchange

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25
causes and consequences of emphysema
Permanent enlargement of the alveoli, deterioration of the alveolar walls, chronic inflammation causes lung fibrosis and loss of lung elasticity (compliance). Eventually, lung tissues collapses during exhalation requiring excessive effort for inhalation. Collapsed tissue also traps gasses reducing efficient gas exchange.
26
causes and consequences of asthma
Autoimmune Persistent inflammation of airways stimulated by irritants. Inflamed airways are already partially obstructed, so additional bronchoconstriction severely impairs air flow through lungs
27
Identify the organs forming the conducting zones in descending order
Passages for delivery of gasses to and from respiratory zones. nose, nasal cavity, pharynx, larynx, trachea, lungs.
28
Respiration processes purposes
move O2 from lungs to tissues, and CO2 from tissues to lungs.
29
4 respiration processes
Pulmonary ventilation: breathing, air in/out lungs External Resp: O2 lungs>blood, CO2 blood>lungs Transport respiratory gases: lungs>tissues Internal Respiration: blood>cells
30
Tidal volume:
Normal amount of air passing into and out of lungs with each normal breath. About 500 ml in healthy adult.
31
Inspiratory reserve volume:
The maximum amount of air that can be inhaled beyond tidal volume. About 2100 to 3200 ml in healthy adult.
32
Expiratory reserve volume:
The maximum amount of air that can be exhaled beyond tidal volume. About 1000 to 12000 ml in healthy adult.
33
Residual volume:
The amount of air which always remain within the lung even after maximum exhalation. About 1200 ml in healthy adult.
34
pulmonary ventilation
respiration process breathing, air in/out lungs
35
external respiration
respiratory process gas exch. O2 lungs/blood CO2 blood/lungs
36
transport of respiratory gases
respiratory process move blood (carrying O2) lungs to tissues, CO2 tissues to lungs
37
internal respiration
resp process move O2 blood to cells, CO2 cells to blood
38
Funct anatomy of Resp Syst: Respiratory Zones
Sites of gas exchange. Includes respiratory bronchioles, alveolar ducts, alveoli. INTERNAL
39
Funct anatomy of Resp Syst: Conducting zones
Leads to respiratory zones EXTERNAL (anywhere air goes) Provides passages for delivery of gasses to and from respiratory zones. Includes nose, nasal cavity, pharynx, larynx, trachea, lungs.
40
nasal cavity
just inside nostrils, extends to pharynx at back of nasal cavity 2 mucus membranes OLFACTORY and RESOIRATORY MUCOSA VESTIBULE HARD & SOFT PALATE
41
olfactory mucosa
small receptors in nasal cavity
42
respiratory mucosa
in nasal cavity, mucus secreting glands lysosome secreting glands lined by cilia
43
vestibule
Just inside nostrils, many hairs (vibrissae) catch particulates.
44
Hard and soft palate:
Form the bottom of the nasal cavity. soft leads to uvula = switch food/air
45
pharynx
Connects the nasal cavity to the esophagus. Consists of nasopharynx, oropharynx, laryngopharynx.
46
Nasopharynx:
Transports only air. Sealed during food swallowing by soft palate and uvula. Connects to nasal cavity through nasal apertures. Ciliated cells. Contains pharyngeal tonsil. collumnar epithelial
47
Oropharynx:
Inferior to soft palate, so transports air and food. Covered by stratified squamous epithelium (more protection cuz food rough). Contains palatine and lingual tonsils.
48
Laryngopharynx:
Transports food and air squamous epithelium. Extends to larynx and is continuous with esophagus. Food travels down esophagus, air travels through larynx down trachea.
49
The Larynx: (Voice box).
Connects laryngopharynx and trachea. Provides opening for trachea acts as a switch, directing food and air produces vibrations (voice).
50
larynx composition
nine different cartilages. During swallowing, the larynx is pulled superiorly (up) and the opening to trachea (glottis - up and seal) is covered by epiglottis (switch).
51
True vocal cords
vibrate as air passes through glottis producing voice. False vocal cords close during swallowing, protecting glottis.
52
Laryngitis
inflammation of vocal folds caused by overuse, infection, irritation.
53
trachea
windpipe. Descends from larynx into mediastinum, branches into primary bronchi. Lined by ciliated psudostratified columnar epithelium with goblet cells secreting mucus. C- cartilage rings stretch and flex
54
bronchial tree
LR primary 3R, 2L secondary tertiary... bronchioles 1mm terminal bronchioles <.5mm
55
lungs
suspended in pleural cavities costal surface under ribs Pulmonary, systemic blood vessels, and bronchi enter through hilus
56
pleurae
Thin membranes (parietal and visceral pleura) surrounding lungs form fluid filled space (pleural cavity). Fluid both allows lungs to move in low friction environment and makes lungs adhere to thorax walls.
57
Pressures affecting respiration
* Atmospheric pressure: The force exerted by the air all around us. * Intrapulmonary pressure: Pressure exerted on the alveoli by the air within the lung. * Intrapleural pressure: Pressure within the pleural cavity.
58
mechanics of breathing
* Intrapulmonary P > Intrapleural pressure = inflates. * If Intrapleural P > intrapulmonary pressure = deflates. * Atm P > intrapulmonary P = enter. * Intrapulmonary P > atm p = exit
59
Respiratory Capacities
Inspiratory capacity: Total amount of air that can be inhaled after a tidal expiration. TV + IRV. Functional residual capacity: Amount of air left in lung after tidal exhalation. RV + ERV. Vital capacity: The total amount of exchangeable air. TV + IRV + ERV. Total lung capacity: Total amount of air contained with a lung. TV + IRV + ERV + RV. About 6000ml in healthy adult
60
Hemoglobin saturation
Cooperatively binds w O2 1. In normal arterial blood (pO2=100 mm Hg), Hb is nearly saturated. 2. Even at lower O2 concentrations (70 mm Hg), Hb is still almost saturated. Lower O2 intake still allows adequate O2 transport to tissues. 3. Only about 25% of O2 is unloaded from tissues under normal circumstances (pO2 40 mm Hg). When tissues become hypoxic (low oxygen) much more O2 is released to correct hypoxia.
61
Haldane effect:
High concentrations of CO2 facilitates O2 release from Hb. * Causes more O2 to be released in anerobic environments.
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Nitric Oxide:
VASODILATOR Nitric oxide can bind to Hb, but only when O2 is also bound. * This means that if more O2 is released from Hb, there is also more NO released which causes vascular dilation and more blood delivery.
63
CO2 transport in blood
1. Dissolved in plasma (7-10%) 2. Chemically bound to Hemoglobin (20%) 3. As bicarbonate ions (70%)
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bicarbonate is important for
stabilizing blood pH
65
Medulla oblongata:
Dorsal respiratory group (DRG): Contains neurons (pacemaker neurons) which fire 12-15 times/minute and cause intercostal muscles and diaphragm contraction causing inhalation. Basic respiratory rhythm. Followed by passive exhalation powered by recoiling of lungs.
66
Suppresses DRG (dorsal resp group)
sleeping pills morphine alchohol
67
Ventral respiratory group (VRG):
Contains neurons which can both cause inhalation and exhalation. Important during forced exhalation.
68
Pons respiratory group (PRG):
Modifies basic resp rhythm Nerves found with the pons which modify basic respiratory rhythm.
69
The Inflation reflex:
mod. BRR can't over inflate Stretch receptors (Piezo mechanoreceptors) within the lungs are stimulated by excessive stretching of the lungs. These receptors send inhibitory signals to the Dorsal respiratory group telling them to stop lung over inflation, preventing lung damage. Receptors reset during lung recoil.
70
Higher Brain center (hypothalamic controls):
mod BRR emotions = erratic breathing!! Respiratory rate is modified by the hypothalamus in response to various emotions (fear, anger, excitement) and to body temperature (extreme cold or heat).
71
Cortical controls:
mod BRR force in/out, hold breath Bypasses the voluntary control of breathing rate. Certain circumstances force involuntary respiration.
72
Chem reg of BRR: CO2
blood stream reg inc CO2 = inc breathing to get rid of (exercise)
73
Chem reg of BRR: O2
peripheral chemoreceptors starved = inc ventilation rate
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Chem reg of BRR: H+
Low pH causes increased respiration to eliminate more CO2 and restore blood pH.
75
Tuberculosis:
Caused by mycobacterium tuberculosis. First exposure is rapidly eliminated or forced into tubercles (calcified or fibrous nodules). TB bacterium exists with tubercles for decades and emerges when immune system is weakened. thick capsule = tricks immune dec elasticity = bleeding
76
Lung cancer:
squamous cell carcinoma, adenocarcinoma, small cell carcinoma. Very low survival rate. Caused by DNA damaging free radicals present in cigarette smoke.
77
Mesothelioma:
Cancer in the pleural membrane. Usually caused by asbestos exposure. walls stick = take up V = dec breathing
78
Carbon Monoxide poisoning:
CO binds about 200X tighter to hemoglobin than O2. When CO is bound to hemoglobin, O2 is unable to bind.
79