Respiratory System Flashcards

1
Q

Functions of the respiratory system

A

-Gas exchange
-Acid-base balance
-Thermoregulation
-Immune function
-Vocalization
-Enhances venous return

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2
Q

What is the order of structures that air passes through to get to the alveoli?

A

1) pharynx
2) larynx
3) trachea
4) bronchi
5) bronchioles
6) alveoli

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3
Q

What type of muscle are bronchioles?

A

Smooth muscle

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3
Q

How do bronchioles control air flow?

A

Through constriction or dilation

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4
Q

Where is the site of gas exchange?

A

Alveoli

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5
Q

Characteristics of alveoli

A

-Thin walled (simple squamous)
-Large surface area for diffusion (75 m square)
-Contain fine elastic fibres
-Pores of Kohn connect to adjacent alveoli

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6
Q

Why are the pores of kohn important?

A

-They help equalize air pressure so that alveoli do not burst

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7
Q

Type 1 vs Type 2 Alveolar cells. What is a third cell?

A

Type 1: make up the walls

Type 2: secretes surfactant

Alveolar macrophages: immune response

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8
Q

Define ventilation

A

The gas exchange between the atmosphere and alveoli in the lungs

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9
Q

Define external respiration

A

the gas exchange between alveoli and blood

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10
Q

Define internal respiration

A

gas exchange between blood and tissues

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11
Q

What is inspiration/expiration dependent upon?

A

Pressure gradients.
Bigger gradient = more air moving

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12
Q

What are the different pressures?

A

Atmospheric: air, typically 760 mmHg at sea level

Intra-alveolar: in alveoli

Intra-pleural: in pleural space, typically 756 mmHg

Transpulmonary: difference between intrapulmonary and intrapleural, typically 760 mmHg

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13
Q

What is Boyle’s law?

A

The pressure exerted by a gas varies inversely with the volume of a gas

If volume increases, then pressure decreases.

If pressure changes, gases will flow to equalize pressure.

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14
Q

Muscles of quiet inspiration

A

Diaphragm and external intercostals (move upwards)

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15
Q

Volume during quiet inspiration

A

Thoracic volume increases (vertically) and lungs stretch

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16
Q

Pressure during quiet inspiration

A

Intrapulmonary pressure decreases
-Air flows into the lungs down its pressure gradient until pressure is the same as atmospheric

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17
Q

Muscles of forced inspiration

A

-Diaphragm and external intercostals
-Recruit scalenus and sternocleidomastoid

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18
Q

Volume during forced inspiration

A

-Greater increase in thoracic volume (vertically)

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19
Q

Pressure during forced inspiration

A

Larger decrease in thoracic pressure
-Larger pressure gradient
-More air flows in

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20
Q

Muscles during quiet expiration

A

-Inspiratory muscles relax (there is no contraction)

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21
Q

Volume during quiet expiration

A

-Thoracic cavity volume decreases and lungs recoil

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22
Q

Pressure during quiet expiration

A

-Increase in alveolar pressure
-Air flows out of the lungs until pressure gradients are equal

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23
Q

Muscles during forced expiration

A

-Relaxation of inspiratory muscles still occurring
-Recruit abdominals and internal intercostals (push up on diaphragm and make space smaller)

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24
Q

Volume during forced expiration

A

-Larger decrease in thoracic volume

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25
Q

Pressure during forced expiration

A

-Larger increase in thoracic pressure
-Larger gradient
-More air out

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26
Q

Which receptors control ventilation?

A

-Chemoreceptors
-Monitor blood gases
-Sensitive to increases in CO2 and H, small reaction to decreases in oxygen

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27
Q

Where do chemoreceptors input to?

A

-Reticular formation of the medulla and pons

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28
Q

Which respiratory centre establishes rhythmic breathing patterns?

A

Pre-Botzinger complex

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29
Q

What does the medullary resp centre control?

A

Dorsal resp group:
-mostly inspiratory neurons

Ventral resp group:
-inspiratory neurons
-expiratory neurons

Receives input from chemoreceptors

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30
Q

Apneustic centre

A

-Prevents inspiratory neurons from being switched off
-Provides extra boost to inspiratory drive

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31
Q

Pneumotaxic centre

A

-Sends impulses to DRG that helps “switch off” inspiratory neurons
-Dominates over apneustic centre

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32
Q

Where are peripheral chemoreceptors located?

A

-Carotid bodies are located in the carotid sinus
-Aortic bodies are located in the aortic arch

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33
Q

How does CO2 affect hydrogen and vice versa?

A

-They combine to make carbonic acid (affects pH of body)
-If CO2 increases, then so does hydrogen (lactic acid)

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34
Q

What does the central chemoreceptors directly monitor?

A

-Located in medulla and monitors CSF
-Monitors increases in hydrogen via CO2 because of blood brain barriers

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35
Q

Central vs peripheral: what portion of the CO2 response do they monitor each?

A

Central: 70%
Peripheral: 30%

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36
Q

What does increased metabolism do?

A

Leads to higher CO2 (and consequently higher H) and lower oxygen

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37
Q

If oxygen levels drop below ______ mmHg, it becomes the major factor in control of breathing.

A

60

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38
Q

What is the only thing that will make oxygen levels drop significantly?

A

High altitude

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39
Q

What does hyperventilation cause?

A

-Increased depth and rate of breathing
-High removal of CO2
-Causes CO2 levels to decline (hypocapnia)
-Lose trigger for inspiration but doesn’t increase oxygen significantly
-May cause cerebral vasoconstriction and cerebral ischemia (headaches)

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40
Q

What role does the hypothalamus and limbic system play?

A

-Modifies rate and depth of respiration with hormones
-Breath may hold in anger or in pain
-Body temperature increases to increase respiratory rate
-Cortical controls bypass medullary controls

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41
Q

Hering-Breuer reflex

A

-Stretch receptors triggered to prevent overinflation of the lungs
-Signals the end of inhalation and allows expiration to occur

42
Q

Pulmonary irritant reflex

A

-Receptors in the bronchioles respond to irritants
-Reflex constriction of air passages
-Receptors in the larger airways mediate the cough and sneeze reflexes

43
Q

What are nonrespiratory air movements?

A

-Cough, sneeze, crying, laughing, hiccups, yawns
-Reflexes

44
Q

What changes does exercise make on respiration?

A

-Increased CO2 production and O2 consumption
-Larger gradients for gas exchange
-Faster and greater diffusion

45
Q

Physical factors influencing pulmonary ventilation

A

-Airway resistance
-Alveolar surface tension
-Lung compliance
-Elastic recoil

46
Q

What is the biggest determinant in airway resistance?

A

Radius of bronchioles

47
Q

What is the equation for airflow?

A

F = pressure gradient between atmosphere and alveoli / resistance

48
Q

Asthma

A

-Severe constriction or obstruction of bronchioles
-Prevents ventilation with mucous

49
Q

What does epinephrine do for airways?

A

-Dilates bronchioles and reduces air resistance
Eg; Epi pens

50
Q

Surface tension

A

-Attracts liquid molecules to one another at a gas-liquid interface
-Resists any force that tends to increase the surface area of the liquid

51
Q

Surfactant

A

-Detergent like lipid and protein complex produced by Type 2 alveolar cells
-Decreases surface tension of alveolar fluid and discourages alveolar collapse

52
Q

Why are premature infants at risk of respiratory distress?

A

-They do not have surfactant yet

53
Q

Lung compliance

A

-Expandability of the lungs
-Relates to effort required to distend the lungs
-Connective tissue makes it more compliant, along with alveolar surface surfactant

54
Q

What diminishes lung compliance?

A

-Nonelastic scar tissue (fibrosis)
-Reduced production of surfactant
-Decreased flexibility of the thoracic cage (paralysis of resp muscles)

55
Q

Elastic recoil

A

-How fast the lungs rebound after being stretched, returning to their pre-inspiratory volume
-Depends on connective tissue in the lungs (elastin and collagen) and surface tension (increases)

56
Q

Tidal volume

A

-Volume of air entering or leaving lungs during a single breath
-500 ml

57
Q

Inspiratory reserve volume

A

-Extra air that can be maximally inspired over and above the typically tidal volume
-3000 ml

58
Q

Inspiratory capacity

A

-Maximum volume of air that can be inspired at the end of a normal quiet expiration
-3500 ml

IRV + TV

59
Q

Expiratory reserve volume

A

-Extra volume of air that can be actively expired by maximal contraction beyond the normal volume of air after a resting tidal volume
-1000 ml

60
Q

Residual volume

A

-Minimum volume of air remaining in the lungs even after a maximal expiration
-1200 ml

61
Q

Functional residual capacity

A

-Volume of air left in lungs at the end of normal passive expiration
-2200 ml

ERV + RV

62
Q

Vital capacity

A

-Maximum volume of air that can be moved out during a single breath following a maximal inspiration
-4500 ml

IRV + TV + ERV

63
Q

Total lung capacity

A

-Maximum volume of air that the lungs can hold
-5700 ml

VC + RV

64
Q

Forced expiratory volume in one second

A

-Volume of air that can be expired during the first second of expiration in a VC determination

65
Q

Dead space

A

-Inspired air that doesn’t contribute to gas exchange
-Anatomical (150ml) or alveolar

66
Q

Minute ventilation

A

Total amount of gas flow into or out of the respiratory tract in one minute

67
Q

Obstructive disease

A

-High compliance
-Low recoil
-Difficult to breath out
-Emphysema, asthma, chronic bronchitis

68
Q

Emphysema

A

-Caused by smoking
-Breakdown of collagen and elastin in septal walls
-Loss of lung recoil
-Tar and mucous production
-Decreased SA and greater diffusion distance

69
Q

Chronic bronchitis

A

-Response to chronic irritants (smoking or pollutants)
-Inflamed airways
-High production of mucous which decreases airway diameter
-Triggers cough reflex and bronchoconstriction

70
Q

Restrictive disease

A

-Low compliance
-High recoil
-Harder to breath in and hard to hold air in long enough for gas exchange
-More collagen
-Fibrosis, asbestos exposure, mesothelioma

71
Q

Which method does gas exchange occur by?

A

Simple diffusion

72
Q

Gas will move from ________ partial pressure to _________ lower partial pressure

A

Higher to lower

73
Q

What is Dalton’s law?

A

-The partial pressure of each gas is directly proportional to its percentage in the mixture.
(Fraction of gas in atmosphere x the atmospheric pressure)

74
Q

What is the fraction of oxygen, nitrogen and CO2 in the air?

A

Oxygen: 21%
Nitrogen: 79%
CO2: <1%

75
Q

Which pressure DOES change to change partial pressures?

A

Barometric or atmospheric pressure changes

76
Q

Why do alveoli contain more CO2 and water vapour than atmospheric air?

A

-Gas exchange in the lungs
-Humidification of air
-Mixing of alveolar gas that occurs with each breath

77
Q

Partial pressures of oxygen and carbon dioxide in atmospheric air (mmHg)

A

P O2 : 160
P CO2 : 0.03

78
Q

Partial pressures of oxygen and carbon dioxide in alveoli (mmHg)

A

P O2 : 104
P CO2 : 40

79
Q

Partial pressures of oxygen and carbon dioxide in arterial blood (mmHg)

A

P O2 : 100
P CO2 : 40

80
Q

Partial pressures of oxygen and carbon dioxide in venous blood (mmHg)

A

P O2 : 40
P CO2 : 46

81
Q

External respiration (influences)

A

-Exchange of O2 and CO2 across the respiratory membrane

Influenced by:
-partial pressure gradients and gas solubilities
-ventilation-perfusion coupling
-structural characteristics of the respiratory membrane

82
Q

What does diffusion depend on?

A

-Concentration gradient
-Diffusion distance
-Solubility
-Surface area in alveoli

83
Q

Fick’s law of diffusion

84
Q

What does fick’s law of diffusion govern?

A

Rate of gas transfer across the alveoli

85
Q

When does the respiratory membrane thicken?

A

-If lungs become waterlogged (edema)

86
Q

What happens to gas exchange when the respiratory membrane thickens?

A

-Surface area decreases
-Gas exchange decreases

87
Q

Even though the partial pressure gradient for CO2 in the lungs is less steep than for O2, why does it still diffuse in equal amounts with oxygen?

A

-CO2 is 20x more soluble in plasma than oxygen, so it readily flows down it’s concentration gradient
-O2 required hemoglobin to diffuse, since it doesn’t want to be soluble

88
Q

Internal respiration

A

Capillary gas exchange in body tissues

89
Q

Partial pressures and diffusion gradients in internal respiration are ________ compared to external respiration.

A

Reversed
-PO2 in tissue is always lower than in systemic arterial blood
-PO2 in venous blood is 40 mmHg and PCO2 is 46 mmHg

90
Q

How does oxygen affect the diameter of arterioles in the alveoli?

A

High oxygen causes vasodilation
Low oxygen causes vasoconstriction

So that they match

91
Q

How does carbon dioxide affect the broncioles?

A

High CO2 causes bronchiole dilation
Low CO2 causes bronchoconstriction

92
Q

% of oxygen transport in blood

A

-1.5% is dissolved in plasma
-98.5% is loosely bound to each Fe of hemoglobin (Hb) in RBCs)
-4 O2 per Hb

93
Q

Percentage of CO2 in its different carrier methods in the blood

A

-10% is physically dissolved
-30% is bound to hemoglobin
-60% travels as bicarbonate, which is formed from carbonic acid

94
Q

How much of its oxygen does Hb unload at the level of the tissue?

95
Q

Rate of loading and unloading of O2 is regulated by:

A

-PO2
-Temperature (lower increases affinity)
-Blood pH (higher increases affinity)
-PCO2 (lower increases affinity)
-Concentration of DPG

96
Q

Hypoxia

A

Inadequate oxygen delivery to tissues

97
Q

How does carbon monoxide poisoning work?

A

-CO has 200x the affinity for Hb
-Binds Hb and doesn’t let it go
-Blocks sites from oxygen

98
Q

Transport and exchange of CO2 in systemic capillaries

A

-Bicarbonate quickly diffuses from RBCs into the plasma
-The chloride shift occurs where Cl moves in from the plasma to balance the outrush of HCO3 from the RBCs

99
Q

Transport and exchange of CO2 in pulmonary capillaries

A

-HCO3 moves into the RBCs and binds with hydrogen to form carbonic acid
-Carbonic acid is split by carbonic anhydrase into CO2 and water
-CO2 diffuses into the alveoli

100
Q

Respiratory acidosis

A

-If ventilation is hindered (emphysema), CO2 may build up
-Hydrogen will also build up
-This will drop the pH
-The kidney will work to correct hydrogen levels

101
Q

Respiratory alkalosis

A

-Fast breathing will cause excessive loss of CO2 and loss of hydrogen
-This will cause the body to be alkalotic

102
Q

Metabolic acidosis

A

-High acid (low pH) due to exercise or a kidney problem
-Triggers faster breathing to help reduce CO2

103
Q

Metabolic alkalosis

A

-Low H
-Breathing will slow down to try and build H and CO2 levels