Respiratory Medicine 🫁✅ Flashcards

1
Q

Primary pneumothorax <2cm Mx

A

Discharge

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2
Q

Primary pneumothorax with >2cm marking. Mx

A

Aspirations (then chest drain if unsuccessful)

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3
Q

Secondary pneumothorax in >50 year old, with >2 cm marking, and/or patient is short of breath… Mx

A

Chest drain

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4
Q

Secondary pneumothorax with 1-2cm marking Mx

A

Aspiration (drain if fails)

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5
Q

Secondary pneumothorax with <1cm marking Mx

A

Give o2 and admit for 24hours

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6
Q

Signs of mild airway obstruction

A

Patient is able to speak and answer the question, cough, and breathe

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7
Q

Symptoms of severe airway obstruction

A

Patient is unable to speak they will only respond to you by nodding, they may be wheezy, unable to breathe, and attempt to cough are silent

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8
Q

How to manage a patient with mild airway obstruction

A

First ask if patient is choking, to know whether they can answer and that it is mild away obstruction. Then encourage patient to cough them self.

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9
Q

Management of patients with severe airway obstruction and his conscious

A

Give five back blows, five abdominal thrusts and continue until successful

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10
Q

Management of severe airway obstruction and unconscious

A

Call an ambulance and start CPR. 30 chest compressions then 2 mouth-to-mouth

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11
Q

The presence of warm flushed skin and bounding pulses is a sign of which type of acute respiratory failure 

A

Type II, because the high CO2 causes an acidosis

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12
Q

Two main investigations to do for a patient with acute respiratory failure

A

ABG to confirm the diagnosis and chest x-ray

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13
Q

Indications for ventilation in acute resp failure

A

O2 therapy doesn’t increase PaO2 to 60. Ph less that 7.25, resp muscle fatigue, apnoea, RR > 30, hemodynamically unstable.

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14
Q

Management for acute respiratory failure. Consider when to give O2. Recall considerations for ventilation

A

Prompt hospitalisation. ABCDE. Aim for oxygen of more than 90% saturation.

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15
Q

Discharge advice to patients following a pneumothorax

A

All patients should stop smoking, do not fly until two weeks after successful drainage (given you have seen a good x-ray). And completely avoid scuba-diving unless the patient has had surgical pleurectomy

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16
Q

Final option for patient if they have recurrent pneumothorax even after chest tube and drainage

A

Refer for video assisted thorascopic surgery to seal the pleura to the thorax

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17
Q

First thing to do in a patient with tension pneumothorax

A

Insert a large ball cannula in the second intercostal space in the mid clavicular line (do not wait for investigations)

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18
Q

Two features that score 3 on Wells criteria for PE

A

Signs of DVT and an alternative diagnosis being less likely and PE

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19
Q

Three features on the wells criteria that score 1.5

A

Heart rate above 100, previous DVT and immobilisation for more than three days or surgery in the past month

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20
Q

Two features that score one on Wells criteria

A

Hemoptysis and malignancy

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21
Q

Patient presents with PE like symptoms and scores more than four on Wells.

What is the initial investigation

A

CTPA, If there is a delay give therapeutic anticoagulation until performed

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22
Q

Following a patient with a Wells score above four and after a CTPA is done and is negative… what next?

A

Proximal leg ultrasound with Doppler to check for DVT

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23
Q

Patient presents with PE like symptoms with a wells score of four or less. First investigation

A

Do a D dimer test

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24
Q

If a patient had a Well’s score of four or less, and the d-dimers is positive what to do

A

Do a CTPA

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25
Q

If a patient has a renal impairment, do you do a CTPA or VQ

A

VQ To avoid contrast nephropathy

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26
Q

Most common finding on an ECG for PE

A

Sinus tachycardia, less commonly S1Q3T3

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27
Q

Role of x-ray in PE investigation

A

To exclude other pathology

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28
Q

First line management of PE

A

Direct oral anti-coagulant

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29
Q

Alternatives to DOAC in management of PE

A

Low molecular weight heparin and dabigatran or low molecular weight heparin and warfarin

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30
Q

If a patient’s DVT was provoked, how long should anticoagulation be done for

A

Three months

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31
Q

If the patient’s PE was unprovoked how long should anticoagulation be for

A

Six months

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32
Q

If a patient PE was due to malignancy How long should anticoagulation be for

A

Between six and three months

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33
Q

First line for massive PE or PE with circulatory failure

A

Thrombolysis

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34
Q

Main investigations for asthmatic suspicious patients. Children have two tests, adults can use another two also.

A

Spirometry and Bronco dilator reversibility test for both. FeNO and metacholine challenge can also be used

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35
Q

When is the fractional exhaled nitrogen oxide test done

A

It is a diagnostic test in adults only for asthma

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36
Q

When is the Metacholine: challenge test done for asthma

A

In adults only, if all of the tests were uncertain

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37
Q

What would be a significant value for bronchodilator reversibility test in an asthmatic

A

An increase in the FEV1 of more than or equal to 12%

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38
Q

Step 1 in asthma treatment

A

Newly diagnosed and not bad asthma. SABA ONLY

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39
Q

Step 2 in asthma treatment

A

For patients not managed on step 1, or with 3 or more symptoms a week, or night time waking. SABA and low dose ICS

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40
Q

3rd step in asthma management

A

SABA, ICS, LTRA

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41
Q

4 step in asthma management

A

SABA, low dose ICS, LABA (with or without the LTRA previously)

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42
Q

5th step in asthma management

A

SABA and MART (with or without LTRA)

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43
Q

6th step in asthma management

A

SABA, Medium dose MART (with or without LTRA)

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44
Q

7th step in asthma management

A

SABA, high dose ICS and trial of additional drug (theo or high dose ICS). With or without LTRA

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45
Q

Asthma Patient on SABA and ICS… not well controlled. Add what?

A

LTRA (not LABA). This is step 2 to 3

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46
Q

Moderate asthma exacerbation is defined
X-X% of PEFR
RR< x
Pulse < x

A

50-75% of PEFR
RR< 25
Pulse < 110

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47
Q

Severe asthma exacerbation is defined
X-X% of PEFR
RR > x
Pulse > x

A

33-50% of PEFR
RR > 25
Pulse > 110

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48
Q

Life threatening asthma exacerbation is defined As?

A

PEFR < 33%, O2 < 92%, silent chest, hemodynamic changes, confusion (AMS) = overrules anything else

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49
Q

Investigation for acute asthma exacerbation

A

ABG, not X-ray unless suspect pneumothorax or life threatening asthma

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50
Q

Who should be admitted to hospital (regarding acute asthma exacerbation)

A

Life threatening cases or severe cases who don’t respond to treatment

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51
Q

When to give oxygen in acute asthma exacerbation

A

If patient is hypoxemic, or if patient is acutely unwell. 15L of supplemental O2 via a non rebreathe mask

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52
Q

General treatment for all patients with acute asthma exacerbation.

A

High dose inhaler SABA (nebulise if life threatening exacerbation). Oral prednisolone (for at least 5 days). IV cortisone for patients unable to swallow.

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53
Q

Discharge requirements for patients with acute asthma exacerbation

A

PEGR > 75%, inhaler technique check, stable on med for 12-24 hours

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54
Q

When could you give ipratropium bromide in acute asthma exacerbation

A

If patient didn’t respond to SABA

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55
Q

Best investigation for COPD

A

Spirometry

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56
Q

Stage 1 COPD

A

FEV1 > 80% predicted

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57
Q

Stage 2 COPD

A

FEV1 50-79% predicted

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58
Q

Stage 3 COPD

A

FEV1 30-49% predicted

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59
Q

Stage 4 COPD

A

FEV1 < 30% predicted

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60
Q

Advise and Vx for patients with COPD

A

Stop smoking, annual influenza, one off pneumococcal, rehab if QoL impaired.

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61
Q

First treatment for COPD

A

SABA or SAMA

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62
Q

If SABA or SAMA doesn’t work for a patient with COPD. Assess what?

A

Steroid responsiveness/asthmatic features

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63
Q

What features suggest asthmatic features/steroid responsiveness in COPD.

A

History of asthma/atopy, raised eosinophils, diurnal variation in FEV1 and peak flow (more than 20%)

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64
Q

If a patient has COPD with asthmatic features and failed on SABA. Do what?

A

SABA or SAMA, and LABA and ICS

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65
Q

If patient is not steroid responsive, has COPD that failed with SABA. Do what

A

SABA, AND LABA AND LAMA

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66
Q

3rd step for COPD treatment (regardless of steroid responsiveness)

A

SABA. LABA, LAMA, ICS

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67
Q

When to give mucolytics in COPD

A

If patient has chronic productive cough

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68
Q

Patient had more than three COPD exacerbations. What should be given as prophylaxis?

A

Oral Azithromycin (azif my magic… no more exac)

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69
Q

Treatment for cor pulmonale

A

Loops and long term o2

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70
Q

2 things that improve COPD survival

A

Quit smoking and long term O2 therapy

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71
Q

Oxygen therapy in COPD. When do we give?

A

Give us O2 less then 7.3, or between 7.3-8 with polycythemia, edema, pulmonary hypertension

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72
Q

Cause of severe exacerbation of COPD

A

Haemophilus I. (Main one).
Streptococcus and moraxella second

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73
Q

How to prevent COPD exacerbations?

A

Oral Azithromycin

74
Q

COPD exacerbation investigation

A

ABG, pulse ox, ecg

75
Q

COPD exacerbation management

A

Nebulised bronchodilator, oral prednisolone, and oral antibiotics (only if patient has signs of pneumonia !)

76
Q

Investigations for suspected pneumonia

A

Chest X-ray, Blood cultures and sputum cultures (amongst other things)

77
Q

CURB65 vs CRB65

A

CURB includes urea, and is done in hospital. CRB65 is fine in community to assess whether to be hospitalised

78
Q

What does CRB65 stand for (pneumonia)

A

Confusion, resp rate > 30, BP < 90/60, over 65 years old

79
Q

How to treat a patient in the community with a pneumonia and CRB65 score of 0-1?

A

Oral amoxicillin (macrolide/tetra if allergic to penicillin)

80
Q

What to do with a pneumonia patient with a CRB65 of 2 or more?

A

Hospital assessment

81
Q

When to give O2 in a pneumonia patient

A

If sats <94%

82
Q

Strep pneumonia treatment

A

Amoxicillin (oral) or benzylpenicillin (IV)

83
Q

Treatment for mycoplasma pneumoniae or chlamydia pneumoniae

A

Clarithromycin

84
Q

Investigations for Tb

A

Mantaux (), chest X-ray (if more acute?)

85
Q

Mantoux less than 6mm

A

Negative. And can give BCG to this patient

86
Q

Mantoux 6-15mm

A

Positive. Can be due to previous Tb or BCG. So no BCG Vx for this patient

87
Q

Mantoux > 15

A

Strongly positive (suggests Tb infx)

88
Q

Active tb patient management

A

Isolate patient. 2 months RIPE, 4 months RI

89
Q

Latent TB management

A

3mo RI or 6mo I

90
Q

If a Tb patient is homeless, a prisoner, or unlikely to comply… what should we do to ensure medicated

A

Directly observed therapy

91
Q

Three criteria for ARDS diagnosis

A

Acute onset (in 1 week), bilateral opacities, PaO2 < 40kPa (Four letters in ARDS add a 0 on, equals 40)

92
Q

Invx for ARDS?

A

Chest X-ray and ABG

93
Q

Management ideas
for an ARDS patient

A

ITU often needed. Oxygenation/ventilation. Consider vasopressors. Treat cause. Prone positioning.

94
Q

Cause of mediastinitis?

A

URI/recent dental infection. Thoracic surgery

95
Q

Investigations for suspected mediastinitis . Complications of mediastinitis ?

A

Blood culture, Chest X-ray or CT. Can lead to severe sepsis, and even constricting mediastinitis (recquire stenting)

96
Q

Management of mediastinitis

A

Antibiotics and drainage of fluid (if so)

97
Q

Most common bacteria associated with Bronchiectasis

A

Hemphilus influenzae (followed by pseudomonas)

98
Q

X-ray finding for Bronchiectasis

A

Tramlines (parallel lines)

99
Q

Investigations for Bronchiectasis

A

CXR, CT and a sputum culture (Identify any colonisers)

100
Q

Management ideas for Bronchiectasis

A

Physical therapy, antibiotics for exacerbations, antibiotics in severe cases, bronchodilators in some,
Surgery if localised m, immunisations,

101
Q

Usual first investigation for a suspected lung cancer patient

A

Chest X-ray

102
Q

Best investigation for lung cancer

A

CT

103
Q

Role of PET scanning in lung cancer

A

Done for non small cell lung cancer To establish eligibility for curative treatment. Also gives good idea for cancer spread

104
Q

When would you consider surgery in small cell lung cancer

A

Very early stages only (T1-2, N0, M0)

105
Q

Limited small cell lung cancer (maybe a bit of spread). Mx?

A

Chemo and radio Tx

106
Q

Patients with extensive small cell lung cancer. Mx?

A

Palliative chemoTx

107
Q

Non small cell lung cancer… if do surgery, what should be done prior

A

Mediastinoscopy to see if there is mediastinal lymph node involvement (CT doesn’t always show)

108
Q

Gimme some facts about non small cell lung cancer management?

A

Poor response to chemo, radiotherapy better. Surgery can be done in 20%

109
Q

How to investigate and diagnose pulmonary hypertension

A

A dx of exclusion. Do CXR, ECG, and consider transthoracic Doppler echocardiography, and swan ganz.

110
Q

What is the general supportive therapy for pulmonary hypertension?

A

Oral anticoagulant, diuretic, o2, digoxin

111
Q

Some pulmonary hypertension treatments

A

Prostanoids, endothelin antagonists, PDE5 inhibitors

112
Q

Epworth scale is for what?

A

A sleepiness scale. And be used to get a better idea of patients sleep

113
Q

Best invx for a patient with potential sleep apnoea?

A

Polysomnography

114
Q

Advice given to most peripheral sleep apnoea patients

A

Lose weight!

115
Q

First line Mx for moderate-severe sleep apnoea

A

CPAP

116
Q

Alternatives to CPAP for mild sleep apnoea (no daytime sleepiness), or patient unable to take CPAP.

A

Mandibular advancement (device or surgery)

117
Q

If patients have excessive daytime sleepiness from sleep apnoea. You should do what??? (Like legal stuff)

A

Inform driver and vehicle licensing agency

118
Q

Investigations for lung contusions (suspicion)

A

Chest X-ray 1st! ABG and pulse ox

119
Q

If patient with lung contusion has severe hypoxia, what must we do?

A

Intubate within an hour

120
Q

Little snapshot of lung contusion management

A

Most heals on it’s own, and with supportive care. Consider oxygen (esp if hypoxia), and closely monitor patient. May need fluids to ensure blood volume stable

121
Q

Organisms colonising CF patients

A

Staph, pseudomonas, burkholderia, aspergillus.

122
Q

CF invx (1st)

A

Sweat test: high chloride in sweat. (>60). Usually give pilocarpine to increase the sweat

123
Q

What newborn screening is done for CF?

A

Immunoreactive trypsinogen test

124
Q

Advise to give to patients with CF?

A

Avoid contact with each other (can spread bacteria between them). Have a high calorie and high fat intake. Do chest physiotherapist and postural drainage twice a day. Take vit supplements

125
Q

What is Lumacaftor and Ivacaftor?

A

For CF patients (homozygous). Ivacfator increases conductance. Lumacaftor increases number of CFTRs send to cell surface.

126
Q

Contraindication for lung transplant in CF?

A

Burkholderia colonisation

127
Q

Role of Creon in CF

A

To replace pancreatic enzymes

128
Q

How to investigate pulmonary fibrosis. Mention 1st and best.

A

1st: chest X-ray (bilateral interstitial shadowing, ground glass and later honeycombing)
Best: CT (need med for diagnosis)
Spirometery is good, and Sonia TLCO

129
Q

Pulmonary fibrosis Mx ideas

A

Mainly rehab, and O2 if needed. Some need transplant. Pirfenidone (antifibrotic) for some.

130
Q

What is Lofgren

A

An acute fulminant form of sarcoidosis. Has bilateral hilar LN, erythema nodosum, fever and polyarthralgia.

131
Q

What is Heerfordts

A

Parotid enlargement, fever and uveitis 2° to sarcoidosis

132
Q

Potential findings for Sarcoidosis, on a CBC

A

Hypercalcemia and high ESR

133
Q

Some Invxs for sarcoidosis

A

Bloods, chest X-ray, spirometer, (biopsy is rare)

134
Q

Stage 1 sarcoidosis

A

Bilateral hilar LN

135
Q

Stage 2 sarcoidosis

A

BHL and interstitial infiltration

136
Q

Stage 3 sarcoidosis

A

Diffuse interstitial infiltration

137
Q

Stage 4 sarcoidosis

A

Diffuse fibrosis

138
Q

When do we give steroids for sarcoidosis patients

A

Stage 2-3: who are symptomatic. Any patient with hypercalcemia or eye/heart/Neuro involvement. Any stage 4.

Not stage 1, or stable asymptomatic stage 2/3

139
Q

Acute pulmonary edema Mx

A

CPAP, O2, morphine, nitrates, loops

140
Q

Hypothyroidism pleural effusion is transudate or exudate?

A

Transudate

141
Q

Aside from pleural aspiration, other investigations important in effusions?

A

ABG, CXR, CTs (helps to find cause, especially in exudative), US (helps to aspirate well)

142
Q

First invx in pleural effusion to get to cause

A

Pleural aspiration

143
Q

If a patient has a pleural effusion in association to sepsis or pneumonia… what do we do

A

Chance of empyema.
Do pleural fluid sampling. If cloudy/turbid = chest drain. If clear but acidic (<7.2) =chest drain.

144
Q

If pleural fluid has protein more than 35, it meanssss??

A

Defo exudate

145
Q

If pleural fluid has protein less than 25, it meanssss??

A

It is a transudate

146
Q

What do you apply if the pleural fluid is between 25-35?

A

Lights criteria

147
Q

Lights criteria for exudate

A

Pleural: serum protein >0.5

Pleural: serum LDH >0.6

(Only need one)

148
Q

A pleural fluid is turbid, low pH, low glucose, high LDH… what you thinking?

A

Empyema

149
Q

Management ideas for pleural effusion

A

Recurrent aspiration with US. Indwelling pleural catheter if needed. Pleurodesis if needed. Opioids to relieve dyspnoea.

150
Q

Big empyema causing bacteria

A

Klebsiella (and lung abscesses)

151
Q

Patient who has pneumonia, now has fever and rigours… consider?

A

Empyema

152
Q

Management for Empyema

A

Thoracentesis, chest drain and prolonged course of Abx

153
Q

First invx for suspected mesothelioma

A

Order Chest X-ray

154
Q

Weight loss, chest wall pain, progressive dyspnoea, worked in shipyard 25 years ago. Thoughts?

A

Asbestos induced mesothelioma

155
Q

Chest X-ray signs of mesothelioma

A

Pleural effusions and pleural thickenings. Do test fluid if effusion present

156
Q

If suspect mesothelioma, and effusion fluid tested, yet cytology comes back negative. Can do what?

A

Local anaesthetic thoroscopy (high diagnostic yield).

157
Q

At what O2, does respiratory failure occur

A

Below 60mmHg or 8kPa

158
Q

Spare space

A

You’re doing great

159
Q

Young patient who is wheezy, and has obstructive spirometry, should be sent for what invx?

A

Bronchodilator reversibility testing. (Improve more than 12% = asthma)

160
Q

How to diagnose/invx a potential occupational asthma case

A

Take peak flow measurements at home and at work

161
Q

COPD exacerbation given all medical therapy, and ABG does not improve. What next?

A

BiPAP

162
Q

Indications for non invasive ventilation?

A

COPD and acidosis. Any type II resp failure. Pulmonary edema (when CPAP doesn’t work). Weaning of intubation

163
Q

Patient with acute asthma exacerbation. It is severe and it is not responding to nebulisers. Should we admit!?

A

Admit patient (severe asthma exacerbation not improving with nebuliser)

164
Q

How to determine if an asthma is specifically an allergic asthma

A

Allergy skin prick test

165
Q

Signs of aspirin exacerbated asthma

A

Severe persistent asthma, aspirin sensitivity, eosinophilia sinusitis, nasal polyps

166
Q

Main treatment for aspirin exacerbated asthma

A

Leukotriene antagonist, stop NSAID

167
Q

Testing for allergic bronchopulmonary aspergillosis

A

Skin test for aspergillus antigen, high IgE to aspergillus, peripheral eosinophilia, bronchiectasis

168
Q

Aside from usual COPD management, what is the indication for lung volume reduction therapy

A

Upper lobe predominant COPD, to remove emphysematous lung

169
Q

Indication for lung transplant in COPD

A

Less than 65 years old, severe disability despite treatment, no co-mob, risk of dying in less than two years

170
Q

When to give omalizumab in asthma

A

Uncontrolled symptoms, evidence of allergy, IGE elevated

171
Q

When to give mepolizumab in asthma

A

When eosinophils are greater than 150. Nothing to do with IGE

172
Q

COPD patient with weight loss… Xray normal, FBC normal etc… cause?

A

The COPD!

173
Q

Details of O2 therapy for COPD exacs patients?

A

Patients with COPD should initially be given oxygen via a Venturi 28% mask at a flow rate of 4 l/min or a Venturi 24% mask at a flow rate of 2 l/min. The target oxygen saturation should be 88–92%

174
Q

CIs for DOACS

A

renal impairment, cirrhosis, pregnancy, mechanical heart valves

175
Q

Abx for atypical pneumonias

A

azithromycin (macrolides)

176
Q

Main Invx for mediastinitis

A

blood culture… rule out sepsis! But also do XRAY/CT

177
Q

A patient who is >= 40 years old presenting with unexplained hemoptysis/other signs should be referred using what?

A

the suspected cancer pathway (within 2 weeks) to exclude lung cancer

178
Q

Patient with severe chest pain, low o2. decreased breath sounds and crackles over the left lung field. The patient’s chest X-ray shows patchy opacities and consolidation in the left lung. PaO2 low. following car crash

A

lung contusion

179
Q

Main Tx for ABPA

A

oral steroids

180
Q

Mild hospital acquired pneumoia abx

A

Intravenous (IV) ceftriaxone or IV levofloxacin

181
Q

svere hospital acquired pneumonia abx

A

IV piperacillin-tazobactam or IV cefepime.

182
Q

Chronic bronchitis Dx

A

Cough/productive for three months in each year and total of two consecutive years