Obstetrics Medicine 🤱🏼 Flashcards
What is the gestational age
Weeks since last menstrual period (2 weeks longer than embryonic age)
Embryonic age vs gestational age
Embryonic age is gestational age - 2wks
HCG pattern in the first 8-10 weeks
Doubles every 48 hours and peaks to 100,000
HCG around 20 wks
12,000
To diagnose pregnancy?
HCG… then if positive do transvaginal ultrasound
Best way to date pregnancy
CRL (done earlier, is more accurate)
5 ways to estimate fetal weight
BPD, head circ, abd circ, femur length, and fundal height on physical exam
Do fetal movements occur sooner or later in multigravida women?
Earlier
Roughly normal weight gain in pregnancy
~25 lbs
CI for a pregnant woman to do exercise
Cervical insufficiency, placenta prévia, amniotic fluid leak, HTN, multiple gestations
Potential side effects of NSAIDs in preg
Oligohydramnios (after 20 weeks), can close PDA. Recall time when we can give low dose?
Prenatal care 1st trimester list
FBC, Rh test/Ab test, urinalysis, Vx (Tdap, influenza), HCG and PAPP-A, US (nuchal translucency),
What next? If mum Rh positive
Don’t worry about haemolytic disease of the newborn
What next? If mum Rh negative
Check if mum has anti Rh antibody
What next? If mum Rh positive , and she doesn’t have anti Rh antibody
Risk for future pregnancy, not this one. Give RhoGAM at 28 weeks and after birth (or after amniocentesis, trauma, etc.). Prevent sensitisation
What next? If mum Rh positive (negative?) and she has antibodies against Rh
Baby is at risk for haemolytic disease of the newborn. So now check fetus Rh (can usually deduce from dads status)
What next? If mum Rh positive and had antibodies against Rh, and baby is Rh+…
Fetal MCA Doppler, umbilical Htc, serial Ab titres in mum. May need to transfuse if severe and delivery at 35 weeks
If pregnancy women has asymptomatic bacteruria. How to Mx
Abx, and repeat culture (30% don’t clear 1st time)
Three microbes that must screen for in pregnancy
Syphilis, HBV, HIV
If women at risk of gestational diabetes, or has a positive challenge test, what do we do
Offer referral for an oral glucose tolerance test at 24-28 weeks
What is the oral glucose tolerance test
100g of glucose given, and measure glucose at baseline, 1 hour, 2 hour and 3 hour.
(Challenge test is just 50g and check after 1 hr)
When should pregnant women get the Tdap?
All! At 27-36 weeks. If they haven’t had any dose (Give 3 dose series)
Two Vxs that all women pregnant should be given
Influenza and Tdap (for the rest, only give if haven’t received)
When to do our GBS check
3rd trimester (do culture). Give Abx if +
When does our 1st trim screening for aneuploidy occur
12-13 weeks
PAPPA and HCG high in X and low in Y & Z
X - downs
Y - edwards
Z - patau
2nd trimester screen
AFP, BHCG, Estriol, Inhibin
Recall 2nd trimester screening results
What is the cell free DNA and when is done
Test of maternal blood for fetal DNA. Done after 10 weeks as a screening method (not Dx’ic)
Easier/more common access for CVS.
Transabdominal
If the CVS doesn’t show anything abnormal, why do we sometimes do another scan in 2 weeks?
Confined placental mosaisism can occur which means DNA from placenta isn’t babies…
When is CVS done?
Weeks 11-14, if there’s indication (higher chance of aneuploidy)
When is amniocentesis done
15-20 weeks
When doing CVS or amniocentesis, do we consider Rh risks
Yes, give RhoGAM
All HIV positive preg mums should receive what?
ART
If HIV viral load in mum is >1000… do we need any delivery changes
Yes. C sec and give IV zidovudine
If fetal HIV count above 50… give what?
ART
If fetal HIV count below 50… give what?
Zidovudine for 4-6 weeks
We all know babies get Hep B Vx given at birth… but what is mum is Hep B +
Vx and HBIg
Do we test for chlamydia and gonorrhea? In preg
Yes, at 1st visit, do a swab
If preg woman positive for gonorrhea? Mx?
Ceftriaxone and Azithromycin (test if cured 2 weeks after)
Tx for pregnancy women with toxo
Pyr-sulf for mum and fetus
If trep and non trep test are positive in first trimester… do what?
Penicillin G (1 dose of 1°/2° or three if 3°)
Parvovirus in >20 weeks women?
Weekly US (MCA Doppler). IU transfusion may be needed
FDA drug pregnancy class
A
B
C
D
X
A no risk and human studies done
B no risk but animal studies done
C no studies done
D evidence of risk
X risk
What is the non stress test?
At 32 weeks, check fetal movements and HR
Reactive non stress test?
2 accelerations in HR in 20 mins. Good sign
Non-Reactive non stress test?
No accelerations in 40 mins… potentially a bad sign. Try again in 30 mins
Uterine artery Doppler. What does REDV and AEDV mean?
Reverse end diastolic flow - normal
Absent end diastolic flow - needs urgent delivery
What is the biophysical profile in pregnancy. When is it done and what 4 parameters does it measure
US and non stress test, done after 28 weeks. Tests fetal moment, tone, breathing, amniotic fluid vol, HR
Biophysical test if 6/10
Repeat in 24 hours
Biophysical test of 0-4/10
C sec
Amniotic fluid index normal values
10-15 cm. less than 5 = oligo. more than 24 = poly
More fetuses… longer or shorter preg?
Shorter
Difference between di/monochorionic and di/monoamniotic
How to diagnose twin twin transfusion syndrome
US
How to diagnose twin twin transfusion syndrome
US
How to Mx twin twin transfusion syndrome
Expectant if mild. Laser coag to close anatomosis and amnioreduction to relieve polyhydramnios
(Twin A closer to cervix) both twins cephalic. How to deliver?
Vaginal delivery
(Twin A closer to cervix) A cephalic, B breach . How to deliver?
Try a vaginal delivery
(Twin A closer to cervix) A if breach. How to deliver?
C sec
When do we do leopald maneuvres to assess presentation?
After 36 weeks
If suspect breech presentation on exam, do what?
US to confirm
If after 36 weeks, fetus is breech, what options do we have
External cephalic conversion or elective C sec
After 28 weeks, how should a pregnant woman sleep
Not on back!
Patient has unexplained vaginal bleeding after 13 weeks…. Mx? Consider Rh, preterm
Give RhoGAM. Assess whether to admit (risk of abruption, preterm, amount of blood). Give CSs if risk of preterm birth
When do we invx vaginal discharge in pregnant women?
If itch, sore, smells or painful
Ectopic pregnancy signs occur how long after last menstrual period
4-6 weeks
Less than x% increase in HCG within 48 hours points toward ectopic pregnancy
35%
First line Invx for ectopic pregnancy
Transvag US
Best and diagnostic Invx for ectopic pregnancy
Exploratory laparoscopy
If TVUS non diagnostic for ectopic pregnancy…. Check what?
HCG every 48 hours. If increasing, likely ectopic (repeat US), if decreasing then likely abortion
Patient has ectopic pregnancy, and is stable, asymptomatic, HCG<5000. How to Mx
MTX and leucovorin. Monitor HCG
If patient has ectopic pregnancy and is symptomatic, HCG > 5000. How to Tx
Salpingostomy (preserved tubal function)
If patient has ruptured ectopic pregnancy. How to Tx
Salpingectomy (doesn’t preserve tubal function)
Threatened abortion
Vaginal bleeding -
Fetal activity -
Conception products -
Os -
Px -
Vaginal bleeding - yes
Fetal activity - yes
Conception products IU
Os - closed
Px - reversible
Inevitable abortion
Vaginal bleeding -
Fetal activity -
Conception products -
Os -
Px -
Vaginal bleeding - yes
Fetal activity - maybe ok
Conception products - visible
Os - dilated
Px - irreversible
Missed abortion
Vaginal bleeding -
Fetal activity -
Conception products -
Os -
Px -
Vaginal bleeding - no
Fetal activity - no
Conception products - no expulsion
Os - closed
Px - irreversible
Incomplete abortion
Vaginal bleeding -
Fetal activity -
Conception products -
Os -
Px -
Vaginal bleeding - yes
Fetal activity - no
Conception products - in cervical canal or IU
Os - Dilated
Px - irreversible
Complete abortion
Vaginal bleeding -
Fetal activity -
Conception products -
Os -
Px -
Vaginal bleeding - yes
Fetal activity - no
Conception products - outside uterus
Os - closed
Px - irreversible
Absent fetal cardiac activity and suspect spontaneous abortion… Invx?
Transvag US. And downtrending HCG
Threatened abortion Mx
Expectant (watch and wait)
Complete abortion Mx
Abx and ergot
Mx of inevitable incomplete or missed abortion
Expectant for 4 weeks. If nothing, then intervene.
Medically: misoprostol (+- mifepristone)
Sx: dilation and curettage (if heavy bleed or septic)
Concealed placental abruption presentation
Presents like preterm labour. Abd pain, rigid uterus but no bleeding
When to do vaginal exam placental abruption?
Don’t! Can worsen bleeding
Signs of placental abruption
Dark red vaginal bleeding
Abd pain, uterine tenderness
Rigid uterus
Fetal distress (decelerations and low fetal movement)
Is the Transabdominal US good for placental abruption
Yes…. But not ideal/reliable
Couvelaire uterus
In abruption, the blood extends into the myometrium then out into the peritoneum
Approach to abruption in stable mum and normal fetus findings. <34th week
Observe. CSs and tocolysis. Aim for normal delivery
Approach to abruption in stable mum and normal fetus findings. 34-36 weeks. Active uterine contractions.
Deliver
Approach to abruption in stable mum and normal fetus findings. 34-36 weeks. No uterine contractions.
Observe
Approach to abruption in stable mum and normal fetus findings. >36 weeks
Deliver
Approach to abruption in unstable mum and alive fetus
Emergency C sec
Approach to abruption in unstable mum and dead fetus
Induce vaginal delivery using meds, or c sec if risk to mum
Different between gestational HTN and preeclampsia
Gestational HTN is HTN after 20 weeks gestation. Preeclampsia is the same, but with Proteinuria and end organ dysfunction
HTN before 20 weeks gestation
Chronic HTN