Respiratory L4: Gas exchange and transport Flashcards
Gas exchange at both the pulmonary-capillary and the tissue-capillary levels involves __________ diffusion of O2 and CO2 down partial pressure gradients.
simple passive diffusion
What is partial pressure?
weight of gas on its own
What is Henry’s Law?
At a given temperature, the amount of a particular gas in solution is directly proportional to the partial pressure of that gas
In Henry’s Law, diffusion occurs just based on ________.
partial pressure (gradients)
Process of gas exchange and transport: Why is there a decreased partial pressure of oxygen? (160 –> 100). What are the 2 reasons?
- Humidity of the air (water vapour is added to existing gas) = decrease pressure
- CO2 out of plasma into alveoli = decrease pressure
- Leave PO2 as 100
- Back to heart to body
What is occurring in this diagram? Mention 2 things.
- Has slightly reduced PO2 when starting- due to R and L anatomical shunt
- Back to pulmonary system to be re-oxygenated
What are 3 other factors (other than partial pressure) that influences the rate of gas transfer?
- Surface area
- Thickness of the membrane (diffusion distance)
- Diffusion coefficient
Alveoli walls have been destroyed –> increased abnormally large alveoli
What are 3 factors that increases the thickness of the membrane?
- pulmonary oedema
- pulmonary fibrosis
- pneumonia
What is the diffusion coefficient (D)?
A constant value related to the solubility of a particular gas in the lung tissue and to its molecular weight.
The rate of gas transfer is directly ________ to the diffusion coefficient (D), a constant value related to the solubility of a particular gas in the lung tissue and to its molecular weight.
proportional
What is the diffusion co-efficent (D) for CO2 compared to O2? Why?
- D for CO2 is 20 times that of O2 because CO2 is much more soluble in body tissues than O2 is.
- The rate of CO2 diffusion across the respiratory membrane is therefore 20 times more rapid than that of O2 .
- The difference in D is offset by the difference in partial pressure. Normally equal amounts of O2 and CO2 are exchanged.
What is the gas transport of O2 and CO2 like?
- Only 1.5 % of the O2 in the blood is dissolved; the remaining 98.5% is transported in combination with Haemoglobin (Hb).
- The majority of CO2 is transported in the blood as bicarbonate
How is O2 transported in the blood?
transported in combination with Haemoglobin (Hb)
How is CO2 transported in the blood?
transported in the blood as bicarbonate
What is a heme molecule?
4 max. O2 molecules = full saturated