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PHYL2062 > Cell Physiology L1 > Flashcards

Cell Physiology L1 Flashcards

1
Q

Every cell is surrounded by a ______.

A

Membrane

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2
Q

What is a membrane potential?

A

Difference between +ve (cation) and -ve (anions) in ICF and ECF

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3
Q

Is the inside of the cell positive or negative?

A

Negative

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4
Q

Is the outside of the cell positive or negative?

A

Positive

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5
Q

The resting membrane potential (RMP) is a balance of (a), (b) and (c) for each ion.

A

(a) concentration gradient
(b) electrical gradient
(c) permeability

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6
Q

The RMP is calculated by the ______ equation.

A

Nernst equation

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7
Q

There are more _____ ions on the inside of the cell.

A

K+ ion

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8
Q

There are more _____ ions on the outside of the cell.

A

Na2+ ion

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9
Q

Resting cells are ____ permeable to K+= greatest influence on RMP

Rest Vm closest to EK

A

Most

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10
Q

What is permeability? How is it calculated?

A

Ability to move across a membrane

Is calculated by the Gold-Hodgkin-Katz equation

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11
Q

What is electrically neutral membrane potential?

A

Has no potential

(eg. 10+ve and 10-ve in cell)

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12
Q

What is potential membrane potential?

A

Imbalance- Potential for work to happen

(Eg. More +ve than –ve)

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13
Q

What is separated charges membrane potential?

A
  • Responsible for potential
  • Membrane isn’t charged
  • Row of +ve outside cell
  • Row of –ve inside cell
  • The rest of the cell is neutral
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14
Q

What is separated charges accumulated along a plasma membrane? Membrane potential

A
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15
Q

What is the magnitude of potential membrane?

A

Membrane C > Membrane B > Membrane A

The greater the separation of charges across the membrane, the larger the potential

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16
Q

ICF is _____ negative than ECF

A

more

17
Q

What are the 3 key ingredients for a membrane potential?

A
  1. Ion concentration gradient (Na2+/K+ pump)
  2. Cell membrane (permeable)
  3. K+ leak channels (ungated ion channels)
18
Q

What are the 2 types of ion channels?

A
  1. Active
    • Keeps Na2+ out
    • Lets K+ in
  2. Passive
    • Allows free flow
19
Q

What is the Nernst equation?

A

E = -RT . log [ion]out

zF [ion]in

E = the equilibrium potential

R = gas constant, T = temp, F= Faraday constant

z = ion valence (e.g. +1 for K+ and Na+, -1 for Cl-)

At 37oC simplifies to: 61 log [ion]out mV

[ion]in

20
Q

What is the RMP for K+? What does that mean and why?

A

Resting cells are permeable to K+ ions

  • RMP close to Nernst potential for K+

EK = 61 log [5 mM] = -90 mV

+1 [150 mM]

(if just K+ involved- most cells are -

21
Q

What is the RMP for Na2+? What does that mean and why?

A

ENa = 61 log [150 mM] = +60 mV

+1 [15 mM]

(very different to RMP -70mV, Na2+ is not very permeable

PHYL2062 (17 decks)

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