Respiratory Drugs

Question 1

Inhaled corticosteriod examples

Answer 1

Beclometasone

Budesonide

Question 2

Inhaled corticosteriod indications

Answer 2

Asthma when reliever is not sufficient

Question 3

Inhaled corticosteriod mechanism of action

Answer 3

Reduces mucosal inflammation
Widens airways
Reduced mucus production
Reduces exacerbations

Question 4

Inhaled corticosteriod ADR

Answer 4

Candidiasis

Horse voice

Question 5

Inhaled corticosteriod cautions

Answer 5

Pneumonia risk possible in COPD at high doses

Question 6

Inhaled corticosteriod DDI

Answer 6

Very few if taken correctly

Question 7

SABA example

Answer 7

Salbutamol

Question 8

Fast acting LABA example

Answer 8

Formoterol

Question 9

Slow acting LABA example

Answer 9

Salmeterol

Question 10

When to use SABA inhaler ?

Answer 10

Symptom relief through reversal of bronchoconstriction when required

Question 11

Beta agonist mechanism of action

Answer 11

Bind to beta 2 receptors and cause activation of adenylyl cyclase increasing production of cAMP. This increases activity of PKA and causes bronchial smooth muscle relaxation.
It also increases mucus clearance by action of cilia

Question 12

Beta agonist ADR

Answer 12

Tachycardia 
Sweating
Palpitations 
Anxiety 
Tremor

Question 13

Beta agonist cautions

Answer 13

LABA should only be prescribed alongside inhaled corticosteriods

Question 14

Beta agonist DDI

Answer 14

Beta blockers reduce effects on beta agonists

Question 15

Montelukast drug class

Answer 15

Leukotriene receptor antagonist

Question 16

Montelukast mechanism of action

Answer 16

Blocks leukotrienes from binding to receptors decreasing bronchoconstriction, mucus production and oedema

Question 17

Montelukast ADR

Answer 17

Headache
GI disturbance
Dry mouth

Question 18

Montelukast DDI

Answer 18

No major drug interactions reported

Question 19

Tiotropium drug class

Answer 19

LAMA

Question 20

Tiotropium indication

Answer 20

Severe asthma

COPD

Question 21

Tiotropium mechanism of action

Answer 21

Blocks vagally mediated contraction of airway smooth muscle

Question 22

Tiotropium ADR

Answer 22

Anticholinergic effects - dry mouth, urinary retention, dry eyes

Question 23

Theophylline drug class

Answer 23

Adenosine receptor antagonist

Question 24

Theophylline indications

Answer 24

Poorly controlled asthma

Question 25

Theophylline mechanism of action

Answer 25

Blocks adenosine receptors causing decreased bronchoconstriction

Question 26

Theophylline cautions

Answer 26

Potentially fatal complications

Narrow therapeutic index

Question 27

Theophylline DDI

Answer 27

CYP450 inhibitors increase conc

Question 28

Ipratropium drug class

Answer 28

SAMA

Question 29

Ipratropium indication

Answer 29

Used alongside beta agonists if poor response alone