Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CPT Drugs > Immune System And Malignant Disease Drugs > Flashcards

Immune System And Malignant Disease Drugs Flashcards

You may prefer our related Brainscape-certified flashcards:
NASM ® CPT flashcards
1
Q

Corticosteriods example

A

Dexamethasone

Hydrocortisone

Prednisolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Corticosteriod mechanism of action

A

Corticosteriods prevent interleukin IL-1 and IL-6 production by macrophages. This causes inhibiton of all stages of T cell activation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Corticosteriods indications

A

Urticaria

RA

SLE

Polymyalgia Rheumatica

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Corticosteriods ADRs

A

Hypertension

Hyperkalaemia

Increased risk of osteoporosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Corticosteriods drug interactions

A

Diuretics

Anti-epileptic drugs

Rifampicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Azathioprine indications

A

IBD

RA

SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Azathioprine mechanism of action

A

Azathioprine inhibits purine synthesis. This occurs as azathioprine is cleaved to from 6-MP which is an anti-metabolite that decreases DNA and RNA synthesis. This causes decreased whitr blood cell production.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Azathioprine ADRs

A

Bone marrow supression

Increased risk of malignancy

Increased risk of infection

Hepatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Azathioprine drug interactions

A

Other immunosuppressants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Azathioprine pre-prescription test

A

TPMT activity test as the TPMT gene is highly polymorphic and in low levels of the gene there is a risk of myelosuppression.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Calcineurin inhibitors example

A

Ciclosporin

Tacrolimus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Calcineurin inhibitor indications

A

Used in transplantation

Atopic dermatitis

Psoriasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Calcineurin inhibitor contra-indications

A

Renal impairment due to toxicity

Check BP and eGFR regularly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Calcineurin inhibitor drug interactions

A

Pomegranate juice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Calcineurin inhibitor ADRs

A

GI upset

Anxiety

Headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Calcineurin inhibitor mechanism of action

A

The drugs bind to proteins and form complexes which bind to calcineurin. This inhibits production of IL-2 which works against helper T cell activation.

17
Q

Mycophenolate mofetil drug class

A

Immunosuppressant

18
Q

Mycophenolate mofetil indication

A

Used in transplantation

SLE

Vasculitis

19
Q

Mycophenolate mofetil mechansim of action

A

The drug inhibits inosine monophosphate dehydrogenase which is required for guanosine synthesis. This impairs B and T cell proliferation. However other rapidilt dividing cells are spared.

20
Q

Mycophenolate mofetil ADRs

A

GI upset

Bone marrow suppression

Headache

increased risk of infection

21
Q

Cyclophosphamide indications

A

Lymphoma

Leukaemia

SLE

Wegener’s granulomatosis

22
Q

Cyclophosphamide considerations

A

Significant toxicity -

Increased risk of bladder cancer

Infertility

Renal impairment

23
Q

Methotrexate indications

A

RA

Malignancy

Psoriasis

Crohn’s disease

24
Q

Methotrexate mechanism of action in malignancy

A

Methotrexate competitively and reversibly inhibits DHFR. This affects purine and thymidine synthesis and therefore inhibits synthesis of DNA, RNA and proteins.

25
Q

Methotrexate ADRs

A

Mucositis

Marrow suppression

Hepatitis - cirrhosis

Infection risk

26
Q

Methotrexate considerations

A

Methotrexate is highly teratogenic and abortifacient- induces abortion

27
Q

Sulfasalazine indications

A

RA

28
Q

Sulfasalazine mechanism of action

A

Inhibiton of T cell proliferation and inhibition of IL-2 production

Reduced chemotaxis and degranulation

29
Q

Sulfasalazine ADRs

A

Myelosuppression

Hepatitis

Rash

Nausea an vomiting

30
Q

Anti-TNF therapy effects

A

Decreased inflammation, angiogenesis and joint destruction

31
Q

Anti-TNF therapy considerations

A

Risk of TB reactivation

CPT Drugs (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions