Respiratory Flashcards
Asthma pathology
IgE ab to allergens
S+S asthma
Cough, SOB, wheeze Worse at night + early in morning
Management of acute asthma attack
Salbutamol inhaler or nebs, high flow O2 if sats <92%
Steroids early - Oral prednisolone or IV hydrocortisone if severe
- add iprotropium if not responding or nebulised MgSO4
If not improving: IV salbutamol and/ or aminophylline
Critical care review if not improving
Pathogen causing bronchiolitis + RF
Respiratory syncytial virus (RSV)
RF: passive smoking
S+S bronchiolitis
Coryzal symptoms, dry cough, SOB, decreased feeding Wheeze (high pitched, expiratory) Hyperinflation of chest Widespread crackles
Often following a viral URTI

Pathology + epidemiology of croup
Laryngotracheobronchitis that causes mucosal infalmmation + increases secretions Oedema of subglottic area Usually caused by parainfluenza virus
Most common between 6 months - 3 years

S+S croup
Barking cough Harsh inspiratory stridor Hoarseness, symptoms of URTIWorse at night
Takes hours - days to come on
Management of croup
Oral dexamethasone or oral prednisolone (takes longer to work)
Budesonide nebs
If severe = adrenaline nebs
Lasts 3-7 days
Pathology of epiglottitis
Intense swelling of epiglottis Caused by haemophilus influenza B

S+S epiglottitis
High fever, toxic looking child Painful throat Saliva drooling down chin Soft stridor Cough is absent

Management of epiglottitis
Intubation IV cefuroxime Rifampicin to rest of house

Causes of pneumonia in children
Newborn: group B strep Infants: RSV, strep pneumonia, haemophilus influenza Children: mycoplasma pneumoniae, strep pneumonia, chlamydia pneumonia
S+S pneumonia
Fever, difficulty breathing Cough Poor feeding Chest/ abdo pain = pleural irritation Transient pleural rub Tachypnoea
Management of pneumonia
Supportive Co-amoxiclav for newborns + severely ill Oral amoxicillin or erythromycin for older children
Causes of tonsillitis
Group A beta haemolytic strep EBV, RSV, rhino + adenovirus
Complications of tonsillitis
Quinsy - peritonsillar abscess Cervical abscess Acute nephritis (2-3 weeks later) Rheumatic fever (1-2 weeks later)

Management of tonsillitis
Penicillin V or erythromycin
Genetics of cystic fibrosis + epidemiology
Defective CFTR protein - its a cyclic AMP dependent chloride channel - controls chloride transport Gene located on chromosome 7 Most common defect is on delta F508
Autosomal recessive
Affects 1 in 2500 newborns
Pathology of CF
Impaired ciliary function Thick meconium produced Mucus secretions in pancreatic ducts Abnormal function of sweat glands
S+S of CF
Perinatal presentation: screening, meconium ileus, prolonged jaundice, haemorrhagic disease
Infancy + children presentation: Recurrent chest infections, poor growth, malabsorption, loose offensive stools, acute pancreatitis, rectal prolapse, diarrhoea, nasal polyps
Infection with staph aureus, haemophilus influenza + pseudomonas aeruginosa Hyperinflation of the chest Pancreatic insufficiency - leads to malabsorption + steatorrhoea
Signs: bilateral changes, clubbing, cough, purulent sputum, wheeze, obstructive FEV1
What is the investigation for CF?
Guithre test - screening of newborn Diagnosed with sweat test >60mmol Cl+
CT head + thorax, genetic testing after diagnosis

Management of meconium ileus in CF
Gastrografin enema but may need surgery
Respiratory management of CF
Physio twice a day Continuous abx (flucloxacillin + azithromycin) Nebulised saline, regular sputum samples
Nutritional management of CF
Oral enteric coated pancreatic replacement therapy (Creon)
High calorie diet Overnight feeding via gastrostomy
Vitamin supplements (K, A, D, E)
Complications of CF
DM Liver disease Bowel obstruction Chest infections Infertility due to absence of vas deferens in males
Survival 40-50 years
Screening for CF
Screen for immunoreactive trypsinogen in heel-prick test in newborns
Bacterial + viral causes of otitis media
RSV, rhinovirus Pneumococcus, H influenza, moraxella catarrhalis
Complications of glue ear
Mastoiditis Meningitis Sinus thrombosis Cerebral abscess

Management of otitis media
Symptomatic Amoxicillin if needed Grommet insertion if persistent

Causes of stridor
Croup, foreign body, epiglottitis Abscess, anaphylaxis
S+S TB
Prolonged fever Malaise, anorexia Weight loss Tuberculous meningitis Cervical adenopathy
Management of TB
Rifampicin, isoniazid, pyrazinamide, ethambutol

Incubation period for whooping cough + causative organism
Bordetella pertussis 7-14 days
S+S whooping cough
Coryzal symptoms initially Paroxysmal/ spasmodic cough then inspiratory whoop Worse at night, may culminate in vomiting During cough, child goes red/ blue in the face Lasts 3-6 weeks, up to 12 weeks
Management of whooping cough
Erythromycin only works if given if catarrhal phase
Complications of whooping cough
Pneumonia Lobal collapse Convulsions due to hypoxia Haemorrhage (nose, eyes, brain)
Investigations + management of bronchiolitis
Nasal viral swab
Most managed at home but hospital admission if:
<50% feeding, lethargy, significant tachypnoea, grunting, cyanosis, sats <94%
Supportive management: O2 + NG feeds
When is bronchiolitis most common, and how many kids get it?
Most common between 2-6 months
80% kids have it by age 2
Ways to give oxygen to babies?
High flow O2 therapy (humidified + warmed, nasal cannula) - can give up to 40L a min
Oxygen box over head
Prognosis for bronchiolitis
Usually lasts 7-10 days, mortality is higher with underlying heart + lung disease
Immunoprophylaxis is available for high risk groups: congenital cardiac or lung disease (ex-prems) + congenital immunodeficiencies. Injections over winter period, once a month for 4/5 months
What score is used to assess croup, and when should a child be hospitalised?
Westley score for croup: assesses chest wall retractions, stridor, cyanosis, consciousness, air entry
Aged <6 months
Poor oral intake
Severe obstruction
Immunocompromised
Differentials for CF (when a child is FTT, RTI, wheezy)?
Immunodeficiencies + PCD
When is a port-a-cath used?
CF

When do peak flows become useful?
Over 5-7 to get a good reading
Management of asthma in >5 y/o
Low dose ICS
+ LABA. If not working, remove + increase ICS. If working but not well, increase ICS and + LTRA
+ theophylline
REFER
+ daily oral prednisolone

Management of asthma in <5 y/o
SABA + ICS/ LTRA (tablet)
REFER

Criteria for acute severe asthma
Sp02 <92%
PEF 33-50%
Can’t complete sentences in 1 breath
HR >125 in kids >5 years; >140 in kids 1–5 years
RR >30 in kids aged >5 years; >40 in kids aged 1–5 years
Criteria for acute life-threatening asthma
SpO2 <92%
PEF <33%
Silent chest, cyanosis, poor resp effort, hypotension, exhaustion, confusion
SE of inhaled steroids
Stunted growth + oral thrush
How much O2 can be delivered in a non- rebreathe mask?
80%
S+S of inhaled foreign body + most common location
Right main bronchus
Wheeze, cough, stridor, absent/ decreased resp sounds
Management of tension pneumothorax
Thoracocentesis
Typically what is the age range for croup + bronchiolitis?
Bronchiolitis = 2-6 mths
Croup = 6 mths - 3 years
Describe PCD
Primary ciliary dyskinesia
50% also have situs inversus
Hearing problems