Respiratory Flashcards
Asthma pathology
IgE ab to allergens
S+S asthma
Cough, SOB, wheeze Worse at night + early in morning
Management of acute asthma attack
Salbutamol inhaler or nebs, high flow O2 if sats <92%
Steroids early - Oral prednisolone or IV hydrocortisone if severe
- add iprotropium if not responding or nebulised MgSO4
If not improving: IV salbutamol and/ or aminophylline
Critical care review if not improving
Pathogen causing bronchiolitis + RF
Respiratory syncytial virus (RSV)
RF: passive smoking
S+S bronchiolitis
Coryzal symptoms, dry cough, SOB, decreased feeding Wheeze (high pitched, expiratory) Hyperinflation of chest Widespread crackles
Often following a viral URTI
Pathology + epidemiology of croup
Laryngotracheobronchitis that causes mucosal infalmmation + increases secretions Oedema of subglottic area Usually caused by parainfluenza virus
Most common between 6 months - 3 years
S+S croup
Barking cough Harsh inspiratory stridor Hoarseness, symptoms of URTIWorse at night
Takes hours - days to come on
Management of croup
Oral dexamethasone or oral prednisolone (takes longer to work)
Budesonide nebs
If severe = adrenaline nebs
Lasts 3-7 days
Pathology of epiglottitis
Intense swelling of epiglottis Caused by haemophilus influenza B
S+S epiglottitis
High fever, toxic looking child Painful throat Saliva drooling down chin Soft stridor Cough is absent
Management of epiglottitis
Intubation IV cefuroxime Rifampicin to rest of house
Causes of pneumonia in children
Newborn: group B strep Infants: RSV, strep pneumonia, haemophilus influenza Children: mycoplasma pneumoniae, strep pneumonia, chlamydia pneumonia
S+S pneumonia
Fever, difficulty breathing Cough Poor feeding Chest/ abdo pain = pleural irritation Transient pleural rub Tachypnoea
Management of pneumonia
Supportive Co-amoxiclav for newborns + severely ill Oral amoxicillin or erythromycin for older children
Causes of tonsillitis
Group A beta haemolytic strep EBV, RSV, rhino + adenovirus
Complications of tonsillitis
Quinsy - peritonsillar abscess Cervical abscess Acute nephritis (2-3 weeks later) Rheumatic fever (1-2 weeks later)
Management of tonsillitis
Penicillin V or erythromycin
Genetics of cystic fibrosis + epidemiology
Defective CFTR protein - its a cyclic AMP dependent chloride channel - controls chloride transport Gene located on chromosome 7 Most common defect is on delta F508
Autosomal recessive
Affects 1 in 2500 newborns
Pathology of CF
Impaired ciliary function Thick meconium produced Mucus secretions in pancreatic ducts Abnormal function of sweat glands
S+S of CF
Perinatal presentation: screening, meconium ileus, prolonged jaundice, haemorrhagic disease
Infancy + children presentation: Recurrent chest infections, poor growth, malabsorption, loose offensive stools, acute pancreatitis, rectal prolapse, diarrhoea, nasal polyps
Infection with staph aureus, haemophilus influenza + pseudomonas aeruginosa Hyperinflation of the chest Pancreatic insufficiency - leads to malabsorption + steatorrhoea
Signs: bilateral changes, clubbing, cough, purulent sputum, wheeze, obstructive FEV1
What is the investigation for CF?
Guithre test - screening of newborn Diagnosed with sweat test >60mmol Cl+
CT head + thorax, genetic testing after diagnosis