Respiratory Flashcards
Treatment of acute exacerbation of COPD
A 5-day course of prednisolone is part of the treatment given for an acute exacerbation of COPD.
Precipitants for asthma attacks
D I P L O M A T s
Drugs - NSAIDs, Beta blockers Infections Pollutants Laughter Oesophageal reflux Mites Allergens Temp - COLD Some exercise
3 causes of airway narrowing in asthma
mucus production
brochoconstriction
mucousal inflammation
Signs of an asthma attack
tachycardia tachypnoea resontant chest on percussion hyperinflated decreased chest well movement
Severe asthma
RR BP Peak exp flow rate Blood gas CO2 / O2 General
>25 breaths per min >110 30-50% CO2 low / normal, hypoxic Anxious
Life threatening asthma
RR BP Peak exp flow rate Blood gas CO2 / O2 General
SHOCC
Silent chest Hypotension One third Cyanoised, CO2 increasing and acidotic Confused
NORMAL CO2 INDICATES LIFE THREATENING
Bed side tests for asthma exacerbation
Observations - RR, HR, Sat, BP
Peak flow
ECG
When to do an ABG in asthma exacerbation
<92% sats
Blood tests in asthma exacerbation
FBC U&Es CRP Infectious screen ABG
Longer term tests in asthma
Lung function
Skin prick
Important social aspects to an asthma hx
Occupation
Pets
Smoking
Allergens
HPC in asthma
Attacks per week
Exaserbations
Been to ITU?
Acute asthma attack - initial medication
Salbutamol inhaler - can give 3 doses 5mg back to back
then doses every 15mins
Severe / life threatening asthma attack - initial medication
Impratropium bromide + salbutamol inhaler
Medication to consider in severe / life threatening
Hydrocortisone / pred
MgSo4
Who should life threatening asthma be stepped up to?
ICU
Asthma long term treatment
Step 1
Step 2
Step 3
Step 4
Beta agonist inhaler
+ICS
+Leukotriene receptor antagoist
+ LABA +/- LRA
Orthopnoea =
SOB on lying flat
Sudden causes of SOB
PE
Inhaled foreign body
Pneumothorax
Acute causes of SOB
Asthma exacerbation
COPD exacerbation
Pneumonia
Chronic causes of SOB (resp)
Asthma
COPD
Pulmonary fibrosis
Cardiac causes of SOB
HF MI Angina Valve disease Arrhythmias
Sudden systemic causes of SOB
Anaphylaxis
Hyperventilation
Anxiety
Acute on Chronic cause of SOB
Metabolic acidosis Thyrotoxicosis Fever Anaemia Obesity Neurological disease
CURB65 score
Confusion Urea 0 >7 mmol/L RR >30 Systolic BP < 90 mmHg or Diastolic BP ≤ 60 mmHg Age ≥ 65
What cancers metastasie to the lung?
breast, kidney, testes and bladder
Signs on examination for lung cancer
Clubbing Cyanosis Consolidation Chest expansion asymmetry? Lymphadenopathy
White out on a chest xray may show?
pleural effusion
or lobular collapse
Hormone syndromes caused by lung cancers
Hypercalcaemia Inappropriate ADH (SCC) Ectopic ACTH (SCC)
Ddx for lung cancer
TB
Pneumonia
Secondary tumour?
Gold standard investigation for lung cancer ?
fiberoptic bronchoscopy
- can take samples and do procedures
Which types of lung carcinoma causes hypercalcaemia?
squamous cell carcinoma
Examples of obstructive defects
Important aspect
COPD
Asthma
Bronchiectasis
REVERSIBLE
Obstructive condition
FVC ?
FEV1/ FVC
FVC same
Ratio reduced
Examples of Restrictive defects
scoliosis fibrosis post trauma Asbestosis NM disorders
Restrictive condition
FVC
FEV1/FVC
FVC = reduced
increased or normal
What is Atelectasis?
Atelectasis is a common post operative complication in which basal alveolar collapse can lead to respiratory difficulty. It is caused when airways become obstructed by bronchial secretions.
Two causes of COPD
Smoking and alpha 1 antitrypsin deficiency
Basis of COPD exacerbation treatment
O SHIT
7-14 days of steroids - 30mg pred
antibiotics if due to infection
consider chest physio and BiPAP
Where is the alpha 1 antitrypsin enzyme found?
liver
Causes of pulmonary fibrosis
Occupational Idiopathic Medication - amiodarone and methotrexate Vasculitis CTD
Clinical features of pulmonary fibrosis
Cyanosis Inspiratory fine creps Cough and SOB Finger clubbing Weight loss Fatigue
Bloods in pulmonary fibrosis
FBC UandE LFT CRP ANCA ACE levels
treatment of idiopathic pulmonary fibrosis
steroids and azathioprine
treatment of extrinsic allergic alveolitis
steroids and remove from precipitant
Pleural plaques indicates what?
exposure to asbestos NOT pulmonary exposure
Special characteristics of pulmonary sarcoidosis?
Erythema nodosum and bilateral hilar lymphadenopathy
Bronchiectasis =
chronic inflammation and infection of bronchial walls leadings to permanent dilations of the airways