Gastroenterology / General surgery Flashcards
Definition of colic
Pain in a hollow organ, contraction causes the pain to come in waves
Presentation of acute abdomen
Acute tenderness over the abdomen Guarding Rigidity of the abdomen ABSENCE OF BOWEL SOUNDS Septic - sweating, pale, weak pulse, shallow breath
Associated symptoms in an abdo pain hx
Vomiting Haematemasis Eating / drinking Swallowing Stools - loose / blood Urine - frequency, urgency, blood Vaginal discharge Menstruation FEVER Weight loss Night sweats
Abdo pain investigations
1) Bloods
2) Bedside
3) Imaging
FBC, U&E, LFT, glucose, CRP, amylase
Urine dip - glucose, infection, pregnancy
CXR - perforation
USS abdo
CT
5 Fs of abdo distension
Fluid, foetus, flatus, fat and faeces
To complete an abdominal examination
Hernial orifices External genitalia PR Urine dip Stool sample if feel appropriate
Where is McBurneys point
2/3 of the way between umbilicus and AIDS
Rovsings sign
Press on RIF and pain in the LIF
What needs to be ruled out in females with suspected appendicitis ?
Ectopic preg
Bed side tests in appendicitis
Urine dip
BM
Preg test
BP
Blood tests in suspected appendicitis
FBC
U&Es
CRP
Imagining in suspected appendicitis?
USS
AB used in appendicitis
Metronidazole and cefuroxime
What should be considered with any change in bowel habit?
malignancy
GI causes of diarrhoea
Infection Malignancy IBD IBS Malabsorption
Systemic causes of diarrhoea
Endocrine
Anxiety
Bacterial overgrowth
Drugs causing diarrhoea
Laxatives
AB
SSRIs
Metformin
Infections leading to blood in stool (4)
E.coli
Shigella
Salmonella
Campylobacter
Social hx in diarrhoea hx
Travel hx
Bed side test with diarrhoea
PR (overflow due to constipation)
Urine dip and culture
Stool sample - viral / bacterial / occult blood
Blood tests in diarrhoea
FBC UandEs LFTs CRP TFTs
Non bedside tests in diarrhoea
GI endoscopy
Imaging in diarrhoea
Abdo x-ray
Abdo US
Treatment of diarrhoea
Treat the cause
Rehydrate
Slow bowel movements (?) - opioids / stop medication
GI causes of N and V
Infection - pancreatitis, pyelonephritis, gastroenteritis, cholecystitis
Obstruction
Inflammatiom
Metabolic causes of N and V
Diabetic ketoacidosis Raised calcium Low sodium Addisions Pregnancy
Neurological causes of N and V
Head trauma
Tumour
Motion sickness
Menieres
Cardiac cause of N and V
Heart attack
Drugs commonly causing N and V
Opioid
AB
Chemo
Alcohol
NICE guideline for referral for suspected bowel cancer
They are aged 40 and over with unexplained weight loss and abdominal pain or
They are aged 50 and over with unexplained rectal bleeding or
They are aged 60 and over with:
Iron-deficiency anaemia or
Changes in their bowel habit
Tests show occult blood in their faeces (new NICE recommendation for 2015).
Presentation of bowel cancer in RHS
Diarrhoea Weight loss Anaemia RIF mass Abdo pain
OFTEN LATE PRESENTING
Presentation of bowel cancer in LHS
Constipation
Bleeding
Mucus
Tenesmus
Signs on exam of bowel cancer
Abdominal mass Enlarged liver (mets) Rectal mass Signs of iron deficiency anaemia
Blood tests in suspected bowel cancer
FBC - look for iron deficiency anaemia
LFT
UandE
CEA - monitor progress
Investigation options in suspected bowel cancer
Colonoscopy
Barium swallow
Imagining - MR / endorectal US
Caecum and right colon affected - surgery ->
Right hemicolectomy
Transverse segment affected - surgery ->
Extended Right hemicolectomy
Descending colon affected - surgery ->
Left hemicolectomy
Sigmoid colon affected surgery ->
sigmoid colectomy
Rectum affected surgery ->
Anterior resection
Low rectum affected surgery ->
abdo-perineal resection with PERMANENT COLOSTOMY
When should radiotherapy be done in bowel cancer?
preoperatively
Screening for bowel cancer in the UK
Flex sigmoidoscopy - age 55+
FOB 70 -74 (male and female)
90% of oesophageal malignancies are?
squamous cell carcinoma
which type of cancer is associated with barretts oesophagus?
adenocarcinoma
Risk factors for oesophageal cancer
Smoking Alcohol Barrets Diet Coeliac disease
Which virus is squamous cell carcinomas associated with?
HPV
Symptoms of oesophageal cancer
Fatigue Increasing dysphagia Odynophagia Hoarseness Vomiting Haematemisis Cough
Signs of oesophageal cancer
Weight loss Anaemia Lymphadenopathy Hepatomegaly Ascites
Where does oesophageal cancer often metastasise to?
Liver
Tests in oesophageal cancer
Blood - FBC, LFTs
Upper GI endoscopy
Barium swallow
Further imaging for staging
Treatment of oesophageal cancer if no mets / not v advanced
oesophageal resection
Treatment of oesophageal cancer if mets / advanced
palliative
Most gastric carcinomas are?
adenocarcinomas
Risk factors for gastric cancer
h.pylori smoking poor diet blood group A chronic gastritis
Symptoms of gastric cancer
B symptoms vomiting abdo pain dyspepsia dysphagia (oesophageal obstruction) may be an upper GI bleed
Signs of gastric cancer
Palpable epigastric mass
Virchows node - CHECK LYMPH NODES
Blood tests in gastric cacner
FBC
LFTs - mets
Gold standard investigations for gastric cancer
Upper GI endoscopy
Barium swallow
Management in localised gastric cancer
Resection / gastrectomy
Management in metastatic gastric cancer
Palliative
Stents if obstructions etc
Risk factors for pancreatic cancer
Smoking
Diabetes
Pancreatitis
Usual type of cancer in the pancreas?
Ductal adenocarcinoma
Symptoms of pancreatic cancer
Usually painless
Abdo mass
Weight loss
May be non specific back pain
Signs of pancreatic cancer
painless progressive jaundice
Bloods in pancreatic cancer
FBC
LFTs
Investigations in pancreatic cancer
USS
CT
ERCP
Management options in pancreatic cancer
Surgical - whipples
Palliative - stenting and pain relief
Oesophageal cancer referal pathway
URGENT DIRECT ACCESS (2ww)
NON URGENT DIRECR ACCESS
UPPER GI ENDOSCOPY
1) Dysphagia or 55+ and weight loss + one of upper abdo pain, reflux or dyspepsia
2) Haematemesis
55+ other upper GI symptoms
Causes of constipation - medical
Diverticulitis IBD IBS Coeliac Immobility Dehydration Raised calcium / phosphate Parkinsons disease Pregnancy HypoT
Surgical causes of constipation
Appendicitis
Malignancy
Ischaemic bowel
obstruction
Drugs causing constipation
Anti cholinergics
Opiates
Iron
Calcium channel blockers
Important questions with constipation
Normal bowel habit - how many stools per day (? <3 per week) and for how long
Over flow diarrohea
Maelena
Pain
Diet
New medications
Red flags - fever/ weight loss / nightsweats
FOREIGN TRAVEL
Examination in constipation
Abdo and PR
Blood tests in constipation
FBC - haematinics
U&Es
TFTs
LFTs
Imaging in constipation
US
Abdo X-ray
CT - extreme
Conservative management in constipation
Exercise and fibre
Types of laxatives - BOSS
Bulking - e.g. methylcellulose
Osmotic - Lactulose
Softer - Docusate
Stimulants - Senna
Causes of acute pancreatitis
G
E
T
S M A S H E D
Gall stones
Ethanol
Trauma
Steroids MUMPS Autoimmune Scorpion venum Hyperlilipidaemia / hypercalacaemia / hyperparathyroidism ERCP Drugs
Define acute pancreatitis
acute inflammation of the pancreas by autodigestion
Grey turners sign =
haemorrage in the flanks
Cullens sign =
bruising at the umbilicus
Presentation of acute pancreatitis
abdo pain radiating to the back - relieved by sitting forward
NandV
Criteria for clinical outcome for pancreatitis
Glasgow score
Blood tests to do in acute pancreatitis
FBC - increased WBC UandE LFTs Glucose - increased Albumin - reduced Calcium - reduced Urea - raised CRP - increased Amylase - raised Serum lipase - raised
Increased ALT in acute pancreatitis suggests?
gall stone aetiology
Imaging in acute pancreatitis
CXR - check for perforation
Glasgow score to send to intensive care?
> 3
Supportive care in acute pancreatitis
O2 Fluids Analgesics Anti emetics Insulin Antibiotics 5-7 days PPI Regular monitoring
Causes of chronic pancreatitis
Alcohol Hypercalacaemia Hyperparathyrodism Hyperlipidaemia Biliary disease Cystic fibrosis
Clinical feature of chronic pancreatitis
Jaundice Abdo pain - radiates to the back, improves on sitting forward Bloating Steatorhhoea Weight loss
Imaging in chronic pancreatitis
CXR
CT
USS
Dyspepsia =
indigestion
Local causes of dyspepsia
GORD H.pylori Gastritis Ulcer - gastric / duodenal Hiatus hernia
Systemic causes of dyspepsia
Infection
Alcohol
Smoking
Drugs causing dyspepsia
NSAIDS
Steroids
Bisphosphinates
Conservative management for dyspepsia
Weight loss
stop smoking
reduce alcohol intake
less hot drinks
Intraluminal causes of dysphagia
Inflammation - oesophagitits
Malignancy
Extraluminal causes of dysphagia
Stricture Malignancy Acalasia Goite Vascular obstruction
Systemic causes of dysphagia
Parkinsons Myasthenia Gravis Scleroderma Bulbar palsy MND
Important questions in dysphagia
Solids / liquids
B symptoms
1st line investigation in dysphagia
endoscopy
Imaging in dysphagia
barium swallow
ct
gall stones made of?
cholestrol, calcium and bile salts
choleithiasis is?
gallstones in the gallbladder
choledocholithiasis is?
gallstones passed into the biliary tree
cholecystitis is?
inflammation of the gallbladder
what percentage of gall stones are radio opaque?
10% seen on x-ray
What increases the incidence of gall stones?
Over weight
Pregnancy
Diuretics
?smoking
main precipitant for mixed stones?
infection
Courvoisiers law?
Pt presents with painless obstructive jaundice with an enlarged gallbladder NOT gallstones
size of gall bladder in
1) gall stone disease?
2) obstruction of biliary tree?
smaller
enlarged
5 Fs of gall stone disease
fat, female, fertile, forty and fair
presentation of gall stones most commonly?
80% asymptomatic
cause of obstructive jaundice due to gall stones?
choledocholithiasis
Imaging option in gall stones?
X-ray
US
MRCP
ERCP
Management of asymptomatic stones found incidentally?
conservative treatment
Medical therapy for gall stones?
pain relief
anti emetics
antibiotics if infection
Surgical treatment used when in gall stones?
symptomatic / complications
What is the surgical treatment for gall stones?
either laproscopic or open cholecystectomy
When inoperable what at the options for symptomatic gall stones?
Could have ERCP or lithotripsy (US shock waves)
Main cause of cholecystitis?
gallstones
Presentation of cholecystitis?
feverish and unwell
URQ pain
previously told had gallstones
Symptoms of cholecystitis
Pain in RUQ which can refer to right shoulder Fever Pt has to take shallow breaths Can have N&V Indigestion
Signs of cholecystitis
fever
tachycardia
increased RR
MURPHY’S sign
- pain when two fingers put on RUQ and pt asked to breath in (gallbladder moves up to the costal margin on inspiration)
Blood tests in cholecystitis?
FBC U&E LFT CRP Amylase ?blood cultures
Medical management of cholecystitis?
Nil by mouth
Fluids
Antibiotics - cover gram -ve and +ve
anti emetic and analgesia
surgical management of cholecystitis?
cholecystectomy - if severe / complications within 72hrs
what is cholangitis?
inflammation of bile duct
Causes of cholangitis
Infection
Iatrogenic - past stent
Obstruction
Charcots triad (only in 25% of those with cholangitis) but what is it?
Jaundice
Fever
RUQ pain
Common presentation of cholangitis?
SEPSIS
Treatment of cholangitis
EMERGENCY - ABCDE….
Gallbladder cancer usually?
adenocarcinoma
RF for gallbladder cancer?
Chronic gallstones
congenital malformation
Presentation of gallbladder cancer
late presentation
weight loss
jaundice
RUQ mass
Organisms that cause vomiting in gastroenteritis
Staph aureus
Bacillus cereus
Organisms causing watery diarrhoea gastroenteritis
Cholera
E.coli (enterotoxigenic)
organisms causing dysentry
Shigella
Campylobacter
E.coli (enterohaemorrhagic)
Salmonella
those at risk of gastroenteritis?
young / old
immunosuppressed
travellers
If symptoms of gastroenteritis emerge
within 4 hours - indicates which type of infection?
12-48hrs - indicates which type of infection?
food poisoning
toxin producing / cell invaders
Treatment of gastroenteritis
most resolve on their own
fluids
anti emetics
rehydrate
AB - if systemically unwell / immunocompromised
three types of bacteria causing gastroenteritis
food poisoning
toxin producing
cell invaders
viruses causing gastroenteritis
norovirus
rotovirus
group most common to contract viral gastroenteritis
children
Classification of an upper GI bleed
mouth to second part of duodenum
Classification of a lower GI bleed
2nd part of duodenum to rectum
Oesophageal causes of bleeding
oesophagitis
mallory- weiz tear
malignancy
Gastric causes of bleeding
gastritis
ulcer
cancer
Small and large bowel causes of bleeding
Cancer Gastritis Inflammatory bowel disease Diverticulitis Ulcer Polyps
Rectal causes of bleeding
Malignancy
Anal causes of bleeding
Fissure
Haemorrhoid
Fistula
Associated symptoms and signs of GI bleeding
Weight loss
Vomiting
Signs of chronic liver disease
Signs of anaemia ?
PMH q. in GI bleed
Binge drinking - MWT
Liver decompensation
Medications leading to GI bleeds
Warfarin Antiplatlets Anticoagulants Steroids NSAIDs Alcohol
Bedside tests in GI bleed
BP (lying and standing)
PR
Monitor urine output
Blood tests in GI bleed
FBC Haematimics LFTs U&Es Clotting screen Group and save
ABG
Imaging in GI bleed
CXR ( look for perforation)
could do barium swallow / endoscopy
Score used to determine prognosis of acute GI bleeds
Rockall
Management of an acute GI bleed
ABCDE
IV access and transfuse if necessary
Manage clotting problems
Endoscopy when they are stable
Interventional radiology - identify bleeding point and stop
Medical management - AB, PPI and H.pylori eradication
Surgery - if failure to stop bleeding
Lifestyle advice post bleeding
Avoid NSAIS and reduce alcohol intake
Treatment if high risk of re bleeding post GI bleed
PPI infusion
Risk factors for hernia
Obesity
Previous surgery
Coughing
Straining due to chronic constipation
Incarcerated hernia =
Hernial contents fixed due to adhesions, surgical emergency
Strangulated hernia
Ischaemia of the bowel contents of the hernia, surgical emergency
Surgical treatment of hernias
Mesh or suture to secure
Where does a femoral hernia sit in relation to pubic tubercle
Below and lateral
Where does an inguinal hernia sit in relation to the pubic tubercle
Above and medial
Strangulation more likely in an inguinal or femoral hernia?
Why?
femoral because the lacunar ligament is sharp
How do femoral hernias present?
Tender swelling in upper medical thigh
Often irreducible
Treatment of femoral hernias
Surgical treatment quickly as likely to strangulate
Indirect hernia passes through?
Direct passes though?
Deep and superficial ring
Just superficial ring
Inidrect or direct hernia has higher chance of strangulation?
Indirect
How to ascertain if an inguinal hernia is direct or indirect
direct reduces on lying down
But also - get the patient to lie down - put finger over the mid point of inguinal ligament (over deep ring) get the patient to stand and cough - direct - no restrained (protrudes) - indirect - restrained
Periumbilical hernia presentation
umbilicus is a semicircle
Umbilical hernia presentation
mass bulges directly from the umbilicus
How to distinguish small bowel from large on x-ray
Valvulae conniventes - span the whole lumen, found in small bowel
Large bowel have haustra - don’t cross the whole lumen
Causes of small bowel obstruction
In the lumen
In the wall
Outside the bowel
1) Polyp
Interssuception
Gallstone
Faeces
2) Tumour
Crohns
Infarction
Stricture
3)
Interssusception
Adhesions
Vovulus
Typical presentation of small bowel obstruction
Crampy / colicky central abdominal pain
Bilious vomiting
Can be some distension
increased bowel sounds - tickling
Examinations in bowel obstruction
Abdo exam
Hernial orifices
PR exam
Blood tests in bowel obstruction
FBC
UandEs
ABG
Amylase
Imaging small bowel obstruction
CXR
Abdo x-ray
Main treatment of small bowel obstruction
Conservative in adults
Put in a drip to rehydrate
Insert a nasogastric tube to remove bowel contents
When is surgery needed to treat small bowel obstruction
Ischaemic bowel
Incarcerated hernia
Cause of large bowel obstruction
Inside the lumen
In the wall
Outside the bowel
1) Polyp
Mass
2) Diverticulitis Crohns Mass Impacted faeces
3)Outside
Volvulus
Adhesions
Small bowel obstruction
Early symptom
Late symptom
Vs
Large bowel obstruction
Vomiting
Constipation
Constipation
Vomiting
Large bowel obstruction presentation
Colicky pain
Distended abdomen (more than in small)
Constipation
Imaging in large bowel obstruction
CXR
AXR
consider sigmoidoscopy, barium enema and CT
Treatment of large bowel obstruction
Medical - drip and suck
- water soluble enema
Surgical
- emergency surgery is ischaemic bowel
- stenting
- laparotomy
Volvulus =
twisting of bowel around its mesenteric attachement
Where does volvulus usually occur?
Sigmoid
Presentation of volvulus
Colicky abdo pain
Distension
Constipation
Types of lesions in
UC
Crohns
Continuous
Skip
The extent of inflammation in at a cellular level
UC
Crohns
Muscosal inflam
Transmural
Which of UC and Crohns commonly has bleeding
UC
Extraintestinal manifestations in IBD
Eyes - Uveitis Joint arthritis Erythema nodosum Pyoderma gangrenosum Clubbing Sclerosing cholangitis -> cirrhosis
Imaging investigations in IBD
Endoscopy
Barium swallow
CT / MR
Colonic surveillance in IBD
10 years after first diagnosis, repeat depending on risk stratification
Prognosis in IBD
life long remitting and relapsing
“cure” in UC
Colectomy
What can precipitate UC
Infection / stress
Gene UC is linked with
HLA-B27
Type of mediated response in UC
T helper - type 2
Severe colitis presenation
fever
weight loss
haemodynamic compromise
Liver condition linked with UC
Sclerosing cholangitis
Blood tests in IBD
FBC
UandE
CRP/ESR
LFTs
Bedside tests in IBD
Stool sample
Faecal calprotectin
Presentation of severe UC in AXR
Loss of colonic markings - lead pipe picture
How to introduce remission in UC
Mild / mod
Severe
Pred, aminosalicylate, steroid enema
IV hydrocortisone with hydration
Maintaining remission in UC
5-Aminosalicylate
Mesalazine
Immunosuppressants
Surgical management of UC
20%
Colectomy / ileostomy
Indications for surgery in UC
Carcinoma
Haemorrhage
Obstruction
Perforation
Complications of UC
Peroration
Bleeding
Toxic mega colon
Colonic cancer risk
Disease associated with Crohns
Ank Spond
Presenation of Crohns
Diarrhoae (non bloody)
Abdo pain - RIF / suprapubic
Weight loss / fever/ malaise
Mouth ulcers
Mild to mod crohns intor remission treatment
Prednisolone / aminosalicylates
Severe crohns intro remission treatment
IV hydrocortisone
IV fluids
Maintaining remission in crohns
Immunosuppresants - azathioprine
Biologics
Indications for surgery in Crohns
Failure of medical therapy
Intestinal obstruction
Perforation
H.pylori eradication treatment
Amoxicillin and clarithromycin + PPI (for a month)
Important q to ask in H.pylori
Had eradication before?
Classification of IBS
Diarrhoea and Constipation
What are bowel changes usually related to in IBS?
Stressful events
Symptoms of IBS
Bloating Pain Feeling of not emptying bowel Nausea Anxiety / depression
Blood tests to exclude other causes when IBS suspected
FBC UandE CRP Haematimics TFTs Coeliac serology Ca-125
Other tests to exclude other causes when IBS suspected
Stool culture
Faecal calprotectin
Urinalysis
?US
Medical treatment for diarrhoea IBS
Imodium
Medical treatment for constipation IBS
Gentle laxative
Antispasmodics
Causes of malabsorption
Failure of digestive enzymes Inflammation Structural abnormalities - resections . diverticulae Pancreas disease CF Coeliac Malignancy
Clinical features of malabsorption
Diarrhoea Weight loss Failure to thrive Letheragy Flatus Ascites and oedema Abdo pain Distension May be vitamin deficiences
Blood tests in suspected malabsorption
FBC Iron studies LFTs Clotting Coeliac serology
Other tests in suspected malabsorption
faecal calprotectin
Faecal appearance and fat collection over 3 days
Faecal elastase
Imaging in malabsorption
endoscopy
+ 55y/o + dyspepsia should have what?
OGD and h.pylori test
<55 with dyspepsia and no red flags
urea breath test
Causes of bleeding from the rectum
Vascular - haemorroids
Trauma - anal fissure
Inflammatory - Crohns / UC
Malingancy
Inital investigations for patients with rectal bleeding
PR
Procto-sigmoidoscopy
If patient with rectal bleeding has change in bowel habit / evidence of IBD what investigations should be done?
colonoscopy
Causes of massive splenomegaly?
CML
Malaria
Myelofibrosis
Causes of splenomegaly
Sickle-cell thalassaemia Rheumatoid arthritis Haemolytic anaemia CLL Infectious mononucleosis
CML
Malaria
Myelofibrosis