respiratory Flashcards
58 yo. M presents to ED with complaints of dry cough. CXR revealed generalized inflamed film throughout. What is the most likely diagnosis?
pneumonitis
Drug known to prevent nosocomial PNA?
sulcarafate (Carafate)
Mucosal Protective Agent
Initial finding associated with pulmonary embolism?
respiratory alkalosis
- s/t ↑ RR = blowing off CO2
Diagnostic of pulmonary HTN?
2D echo
Your patient is intubated on the following settings: SIMV/FiO2 .6/PEEP 5. You notice shunting. What should your next action be?
Increase PEEP from 5 to 10 to recruit alveoli and increase surface area to improve oxygenation
32 yo. M with PMH significant for mitral valve replacement now complains of wheezing during physical activity 2-3 times/week. What should you do next?
Send patient for PFT.
What is the pathology of asthma?
↑ response/hyperresponse of trachea, bronchi to stimuli
- acute inflammation
- widespread airway narrowing
- smooth muscle hypertrophy
- viscid mucus plugging up airways
- mucosal edema, hyperemia, mucus gland hypertrophy
asthma: hallmark s/s - top 3 + 7 more
- difficulty speaking in sentences
- pulsus paradoxus gt 12 mmHg (none in COPD!)
- hyperresonance
respiratory distress @ rest, RR 28+, cough, use of accessory muscles, chest tightness, diaphoresis, HR 110+
PFT value suggestive of obstructive disease?
↓ FEV 1
Which acid-base imbalance is associated with asthma?
Respiratory Alkalosis w mild hypoxemia
asthma PFT values at which hospitalization is recommended x4
FEV 1 lt 30% predicted
– OR –
doesn’t increase to at least 40% predicted after 1 hr tx
PEAK FLOW lt 60 L/min initially
– OR –
doesn’t increase to gt 50% predicted after 1 hr tx
ominous findings assoc w asthma exacerbation
- signs x5
- lab x 1
fatigue, absent breath sounds, paradoxical chest/abd movement, inability to retain recumbency, cyanosis
- hypercapnea: pCO2 45+ = EMERGENCY
- Daily maintenance drug for outpatient asthma mgmt: MOA & name
MOA: inhaled corticosteroid
budesonide (Pulmicort)
SE associated with inhaled corticosteroids used daily as maintenance drug for asthma? x3 + 1 pt education
candidal infection of the oropharynx
dry mouth
sore throat
- educate patient to rinse mouth
Ex: budesonide (Pulmicort)
asthma: outpatient mgmt x 6 meds (class & name) + indications
- SABA - albuterol/Proventil: sx relief, breakthrough, or pre exercise
- inhaled corticosteroid - budesonide/Pulmicort: daily maintenance, ↑ if persistent sx
- LABA - salmeterol/Serevent: for persistent sx
- theophylline or antimediators: for persistent sx
- inhaled anticholinergic - ipratropium bromide/Atrovent: add if necessary (secretions)
- anti-leukotrienes - montelukast/Singulair: chronic asthma maintenance (stabilization)
If asthma sx persist, what pharm interventions are indicated? x4
↑ inhaled corticosteroids
add LABA (salmeterol/Serevent)
add theophylline or antimediators
indications for ipratroprium bromide (Atrovent) & MOA
secretion management in asthma
MOA: inhaled anticholinergic
What drug + MOA is indicated in the chronic management of asthma?
montelukast (Singulair)
MOA: anti-leukotriene
think: stabilization
Which drugs x2 have BBW: “Do not take during acute asthma exacerbation?”
LABA
anti-leukotrienes
asthma: inpatient mgmt
- O2 (2 - 3L/min)
- mild to mod: ABG not necessary if SaO2 90+
- severe: initial ABG
- hydration (PO or IVF)
- inhalation sympathomimetics (alupent, proventil, ventolin)
- corticosteroids if no response to sympathomimetics (methylprednisolone)
- parenteral sympathomimetics in pts unable to cooperate (aqueous epinephrine)
- anticholinergic (atrovent MDI)
Status asthmaticus is…
severe, acute asthma that is unremitting, poorly responsive, and life threatening.
note: clinical findings NOT reliable indicators of severity
status asthmaticus: gold standard interventions x4
IV D5 1/2NS
Intubation (pt looks bad)
Continuous pulse ox
ABG q 10-20 min
Monitor pulse ox and ABGs in status asthmaticus how often?
Continuous pulse ox
ABG q 10-20 min
chronic bronchitis is…
- excessive secretion of bronchial mucus
- productive cough 3+ mo over 2+ consecutive yrs
emphysema is…
abnormal, permanent alveoli enlargement
ABG assoc w chronic bronchitis + why.
hypercapnia + hypoxemia
- air trapped in alveoli, over time chemoreceptors reset to accommodate high CO2 levels
CXR findings associated with COPD
hyperinflation: low, flattened diaphragm
bulla, blebs
COPD: outpt mgmt x4
- smoking cessation
- avoid irritants/allergens
- postural drainage: clear excess secretions
- inhaled: ipratroprium bromide (Atrovent) or sympathomimetics – MAINSTAY
58 yo M w PMH COPD; home O2 2L NC coughing up purulent/ thick/ yellow mucous. Management plan?
O2 NC 2-4 L min or 24-28% venti mask Start antibiotics - 7-10days Ampicillin or amoxicillin 500 mg QID PO for 7-10days Doxycyline 100 mg BID Bactrim DS 1 tablet BID
Most common clinical presentation of TB?
Pulmonary disease.
TB is systemic and often asymptomatic.
TB: classic s/s x4
- MAJORITY ARE ASYMPTOMATIC*
- weight loss
- low grade fever
- night sweats
True or False: A positive PPD is diagnostic for active TB dx?
False. Positive PPD shows exposure; not active disease.
What are the drugs + doses in initial TB treatment?
R I P E
Rifampin 600 mg
Isoniazid 300 mg
Pyrazinamide 1.5 - 2.0 g
Ethambutol 15 mg/kg
TB tx: dosages x3 steps
R I P E
DAILY FOR 2 MO: Isoniazid 300 mg + Rifampin 600 mg + pyrazinamide 1.5-2.0 gm (can include E here)
THEN, DAILY 4 MO: R & I
DROP E: if tb fully susceptible to R & I
TB + HIV: tx duration
9 mo - 1 year
TB: monitoring protocol for newly dx x3 steps
FIRST SIX WEEKS AFTER INITIATION OF TX: weekly sputum smears & cultures
THEN MONTHLY until neg cx documented
IF SX CONTINUE OR + CX AFTER 3 MO: suspect drug resistance
TB: baseline labs ordered with initiation of treatment? What happens to those with normal baseline?
LFT
CBC
serum creat
If normal labs @ baseline, monthly labs not required - but monitor for sx drug toxicity.
TB: ethambutol considerations x2
visual acuity changes, red-green color blindness
+PPD is an indication for which drug & dosage?
INH - 6 mo
pneumonia is…
inflammation of LOWER respiratory tract
- r/t infection via aspiration, inhalation, hematogenous dissemination
most common causative agent of CAP
Strep. pneumoniae
gram + !
pneumonia: gold standard for dx
CXR: infiltrates
Blood cultures x 3
CAP: mgmt for under 65 x4
MACROLIDE - 1 of the following:
- azithromycin (Zithromax)
- clarithromycin (Biaxin)
- erythromycin
OR
TETRACYCLINE: doxy
CAP: mgmt 65+ or comorbs x4
FLUOROQUINOLONE
- levofloxacin (Levaquin)
- ciprofloxacin (Cipro)
- moxifloxacin (Avelox)
- gemifloxacin (Factive)
pneumonia: inpt ICU mgmt (rx only) x3
BETA LACTAM
- ceftriaxone (Rocephin)
p l u s
FLUOROQUINOLONE //or// - azithromycin (Zithromax): resistance likely, avoid
Pseudomonas pneumonia: inpt ICU mgmt (rx only) x5
antipneumococcal/antipseudomonal beta lactam
- piperacillin-tazobactam (Zosyn)
- cefepime (Maxipime)
- meropenem (Merrem)
PLUS
- ciprofloxacin (Cipro)
//or//
- levofloxacin (Levaquin)
community acquired MRSA pneumonia: rx x2
vancomycin
//or//
linezolid
What consult is necessary when ordering Linezolid?
ID
HAP: definition + most common causative organisms
pneumonia that occurs 48 hrs + after admission & not incubating @ admission (VAP, HCAP)
Staphylococcus aureus
Streptococcus pneumoniae
Haemophilius influenzae
VAP: definition + most common causative organism
Pseudomonas
pneumothorax pathophys
gas enters pleural space
↑ pleural pressure = collapsed lung
impairs respiration
pneumothorax: hallmark s/s x3
hyper-resonance affected side (d/t air trapping)
diminished BS & diminished fremitus affected side
mediastinal shift toward unaffected (tension pneumo)
gold standard for pneumothorax dx
CXR
When does pneumothorax require intervention?
when larger than 20% – pt will become symptomatic
Intervention for non-emergency pneumothorax?
chest tube @ 4th - 5th ICS MAL
STAT intervention for tension pneumothorax?
needle thoracostomy @ 2nd ICS MCL
leading cause of inpatient hospital death
pulmonary embolism
pulmonary embolism: risk factors x6
immobility venous stasis hypercoagulable states endothelial damage recent surgery of a long-bone PO contraceptives