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Pharmacology > Respiratory > Flashcards

Respiratory Flashcards

1
Q

albuterol metabolized how

A

COMT/MAO

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2
Q

bioavailability of oral albuterol

A

15-70%

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3
Q

half life of oral albuterol

A

6-8 hours

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4
Q

what allows salmeterol to have a longer duration of effect?

A

large side chain that also binds/dual binding

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5
Q

oral albuterol onset

A

30-60 minutes orally

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6
Q

oral albuterol peak

A

1-3 hours

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7
Q

salmeterol duration

A

12 hours

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8
Q

Ipratropium duration

A

6-8 hours

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9
Q

tiotropium duration

A

24 hours

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10
Q

where is tiotropium metabolized

A

kidneys

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11
Q

What p450 is fluticasone metabolized by

A

CYP3A

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12
Q

Montelukast pharmacodynamics

A

competitive inhibitor at LT1, so stops spasm and infiltrates

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13
Q

Montelukast duration

A

10-15 hours

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14
Q

is Montelukast used for COPD

A

no

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15
Q

qualitiatively how is Montelukast oral absoprtion

A

good

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16
Q

what’s relationship between food and montelukast

A

decreases bioavailability by 40%

17
Q

where is montelukast metabolized

A

liver

18
Q

what enzymes is montelukast metabolized by

A

CYP3A/2C9

19
Q

montelukast side effects

A

GI, nausea, vomiting, CNS, mild headaches, hepatitis

20
Q

Montelukast is used as a treatment for which asthma

A

aspirin induced b/c if you block COX, metabolism of intracellular lipids moves to leukotrienes, so montelukast is used as treatment for this

21
Q

Disodium cromoglycate pharmacodynamics

A

-inhibits chloride channels and calcium flux
which reduces release of preformed cytokines from T cells and eosinophils
-suppresses effects of kinins on inflammatory cells

22
Q

diphenhydramine half life

A

6-8 hours

23
Q

fexofenadine half life

A

25 hours

24
Q

how are H1 antagonists metabolized

A

CYP3A

25
Q

do anti- H1 receptors enter CNS

A

yes

26
Q

antihistamine un obvious side effects

A

headaches; GI disturbances

27
Q

Histamine drug-drug interactions

A

inhibitors of metabolism prolong QT and lead to VT

28
Q

Mepolizumab

A

anti IL-5

29
Q

Omalizumab

A

binds to Fc portion of IgE

30
Q

4 contraindications for asthmatics

A

beta blockers
cholinergics
adenosine
ACE-I

31
Q

disodium cromoglycate indications (2)

A

asthma and rhinits

32
Q

Epoprostenol and Trioprostenol are what class of drugs

A

prostacyclin analogs that lead to vasodilation

33
Q

Bosentan what class of drugs

A

endothelin antagonist

34
Q

nintedanib what class of drugs

A

tyrosine kinase inhibitor

35
Q

inhaled albuterol onset

A

minutes

36
Q

inhaled albuterol peak

A

15-30 min

37
Q

inhaled albuterol duration

A

4-6 hours

38
Q

fexofenadine pharm class

A

anti histamine

Pharmacology (9 decks)

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