Respiratory Flashcards
albuterol metabolized how
COMT/MAO
bioavailability of oral albuterol
15-70%
half life of oral albuterol
6-8 hours
what allows salmeterol to have a longer duration of effect?
large side chain that also binds/dual binding
oral albuterol onset
30-60 minutes orally
oral albuterol peak
1-3 hours
salmeterol duration
12 hours
Ipratropium duration
6-8 hours
tiotropium duration
24 hours
where is tiotropium metabolized
kidneys
What p450 is fluticasone metabolized by
CYP3A
Montelukast pharmacodynamics
competitive inhibitor at LT1, so stops spasm and infiltrates
Montelukast duration
10-15 hours
is Montelukast used for COPD
no
qualitiatively how is Montelukast oral absoprtion
good
what’s relationship between food and montelukast
decreases bioavailability by 40%
where is montelukast metabolized
liver
what enzymes is montelukast metabolized by
CYP3A/2C9
montelukast side effects
GI, nausea, vomiting, CNS, mild headaches, hepatitis
Montelukast is used as a treatment for which asthma
aspirin induced b/c if you block COX, metabolism of intracellular lipids moves to leukotrienes, so montelukast is used as treatment for this
Disodium cromoglycate pharmacodynamics
-inhibits chloride channels and calcium flux
which reduces release of preformed cytokines from T cells and eosinophils
-suppresses effects of kinins on inflammatory cells
diphenhydramine half life
6-8 hours
fexofenadine half life
25 hours
how are H1 antagonists metabolized
CYP3A
