ANS Flashcards
M1
- cholinergic/adrenergic
- location
- mechanism
- 2nd messenger
- Action
- cholinergic
- nerve endings
- Gq
- increased IP2 and DAG
- activate myenteric plexus
M2 cholinergic/adrenergic - location -mechanism -2nd messenger -Action
-cholinergic
-heart, some nerve endings
-Gi
-decreases cAMP, activates K+ channels
Slows SA node
M3
- cholinergic/adrenergic
- location
- mechanism
- 2nd messenger
- Action
- cholinergic
- smooth muscle, glands, endothelium
- Gq
- increased IP3, DAG cascade
- contract detrusor, increase salivation
Nn
- cholinergic/adrenergic
- location
- mechanism
- 2nd messenger
- Action
- cholinergic
- ANS ganglia
- Na-K ion channel
- Na
- Depolarizes postgang fiber, evokes AP
Nm
- cholinergic/adrenergic
- location
- mechanism
- 2nd messenger
- Action
- cholinergic
- neuromuscular plate
- Na-K ion channel
- Na
- depolarizes muscle cell and evokes AP and contraction
A1
- cholinergic/adrenergic
- location
- G protein
- 2nd messenger
- Action
- adrenergic
- smooth muscle (especially vasculature) , glands
- Gq
- increase IPR, DAG
- increase Ca and causes contraction of vascular SM and/or secretion from glands
A2
- cholinergic/adrenergic
- location
- G protein
- 2nd messenger
- Action
- adrenergic
- nerve endings and some smooth muscle
- Gi
- decrease cAMP
- decrease transmitter release in the nerve and decrease contraction in smooth muscle
B1
- cholinergic/adrenergic
- location
- G protein
- 2nd messenger
- Action
- adrenergic
- cardiac muscle and JGA
- Gs
- increase cAmP
- increase HR and contractility and renin release
B2
- cholinergic/adrenergic
- location
- G protein
- 2nd messenger
- Action
- adrenergic
- smooth muscle, liver,heart
- Gs
- increase cAMP
- relax bronchiolar smooth muscle; increase glycogenolysis; increase HR and contractility
B3
- cholinergic/adrenergic
- location
- G protein
- 2nd messenger
- Action
- adrenergic
- adipose cells
- Gs
- Increase cAMP
- increase lipolysis
Dopamine
- cholinergic/adrenergic
- location
- G protein
- 2nd messenger
- Action
- adrenergic
- smooth mucle
- Gs
- increased cAMP
- relax vasculature in renal arterioles
Phenylephrine Description
synthetic alpha receptor agonist that is most selective for a1
Phenylephrine Action
vaso and venoconstriction by stimulating contraction of vascular smooth muscle
Phenylephrine Indications (3)
Nasal decongestant
Mydriatic (pupil dilator)
increased BP in vasodilator state
Other facts about phenylephrine (3) -potency compared to Norepi -deactivation -routes
less potent than norepi
not deactivated by COMT
can be given topically and IV
Clonidine short card info
Description
-selective A2 agonist
Clonidine short card Action
stimulate a2 in brianstem, causes down regulation of sympathetic nervous system
Clonidine indications (short card) (2)
treat hypertension
treat migraine
Clonidine other facts
- route
- side effects
- overdose effect
- orally or patch
- sedation/ dry mouth
- if given IV or OD can cause high BP
Phenylephrine brand name
Neosynephrine
Clonidine brand name
Catapres
Isoproterenol brand name
Isuprel
Isoproterenol description
B1/B2 receptor agonist
isoproterenol actions
potent b1/b1 agonist