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Pharmacology > Anti-Anginal > Flashcards

Anti-Anginal Flashcards

1
Q

nitro pharm dynamics

A

reduced from NO2 to NO which leads to cGMP production which causes vasodilation

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2
Q

how well is nitro absorbed

A

well, but high 1st pack effect

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3
Q

best route for Nitro

A

sublingual tablet or spray

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4
Q

toxcicity

A

headache

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5
Q

major nitro interactions

A

viagra

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6
Q

nitro special consideration about use

A

tolerance can develop quickly so need breaks

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7
Q

aspirin therapeutic class

A 
analgesic
anti-inflam
antiplatelet
antipyretic
prevention of MI
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8
Q

aspirin pharmacodynamics

A

COx-1 and Cox-2 inhibitor so decreased platelet aggregation

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9
Q

aspirin oral absoprtion

A

60%

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10
Q

aspirin half life

A

3-4 hours

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11
Q

aspirin duration

A

4-24 hours

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12
Q

how is aspirin excreted

A

mostly as salicylate metabolites in urine

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13
Q

aspirin toxicity (3)

A

GI tract ulcers
bleeding disorders
tinnitus

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14
Q

aspirin interactions (2)

A

inhibits methotrexate and potentiates bleeding from warfarin

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15
Q

avoid aspirin in which patients

A

nasal polyps and asthma

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16
Q

Clopidogrel pharm class

A

inhibitor of ADP induced platelet aggregation

17
Q

Clopidogrel pharmacodynamics

A

irreversible inhibition of ADP receptors which prevents platelet aggregation

18
Q

Clopidogrel what is more active pure drug or metabolite

A

metabolite

19
Q

how is Clopidogrel absorbed (qualitatively)

A

well

20
Q

Clopidogrel onset

A

1-2 hours

21
Q

where is Clopidogrel metabolized

A

liver

22
Q

Clopidogrel half life

A

8h

23
Q

Clopidogrel interactions

A

may inhibit CYP3A

24
Q

Abciximab pharmacodynamics

A

noncompetitive inhibitor of GP IIb/IIIa receptor so prevents binding of fibrinogen, vWF and other ligands needed to activate platelets

25
Q

how is Abciximab administed

A

IV bolus followed by IV infusion

26
Q

Abciximab half life

A

30 min

27
Q

Abciximab effect on bleeding time when discontinued

A

declines

28
Q

when is Abciximab contraindicated

A

aneurysm, AV malformation, bleeding, coagulopathy, GI bleed, intracranial mass

29
Q

N2O

A

nitrous oxide

30
Q

NO2

A

nitrite

31
Q

NO3

A

nitrate

32
Q

NO

A

nitric oxide

33
Q

what drug is contraindicated for prinzmetal angina

A

Beta blockers

Pharmacology (9 decks)

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