Anti-Anginal Flashcards

1
Q

nitro pharm dynamics

A

reduced from NO2 to NO which leads to cGMP production which causes vasodilation

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2
Q

how well is nitro absorbed

A

well, but high 1st pack effect

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3
Q

best route for Nitro

A

sublingual tablet or spray

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4
Q

toxcicity

A

headache

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5
Q

major nitro interactions

A

viagra

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6
Q

nitro special consideration about use

A

tolerance can develop quickly so need breaks

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7
Q

aspirin therapeutic class

A
analgesic
anti-inflam
antiplatelet
antipyretic
prevention of MI
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8
Q

aspirin pharmacodynamics

A

COx-1 and Cox-2 inhibitor so decreased platelet aggregation

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9
Q

aspirin oral absoprtion

A

60%

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10
Q

aspirin half life

A

3-4 hours

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11
Q

aspirin duration

A

4-24 hours

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12
Q

how is aspirin excreted

A

mostly as salicylate metabolites in urine

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13
Q

aspirin toxicity (3)

A

GI tract ulcers
bleeding disorders
tinnitus

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14
Q

aspirin interactions (2)

A

inhibits methotrexate and potentiates bleeding from warfarin

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15
Q

avoid aspirin in which patients

A

nasal polyps and asthma

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16
Q

Clopidogrel pharm class

A

inhibitor of ADP induced platelet aggregation

17
Q

Clopidogrel pharmacodynamics

A

irreversible inhibition of ADP receptors which prevents platelet aggregation

18
Q

Clopidogrel what is more active pure drug or metabolite

A

metabolite

19
Q

how is Clopidogrel absorbed (qualitatively)

20
Q

Clopidogrel onset

21
Q

where is Clopidogrel metabolized

22
Q

Clopidogrel half life

23
Q

Clopidogrel interactions

A

may inhibit CYP3A

24
Q

Abciximab pharmacodynamics

A

noncompetitive inhibitor of GP IIb/IIIa receptor so prevents binding of fibrinogen, vWF and other ligands needed to activate platelets

25
how is Abciximab administed
IV bolus followed by IV infusion
26
Abciximab half life
30 min
27
Abciximab effect on bleeding time when discontinued
declines
28
when is Abciximab contraindicated
aneurysm, AV malformation, bleeding, coagulopathy, GI bleed, intracranial mass
29
N2O
nitrous oxide
30
NO2
nitrite
31
NO3
nitrate
32
NO
nitric oxide
33
what drug is contraindicated for prinzmetal angina
Beta blockers