Anti-Anginal Flashcards
nitro pharm dynamics
reduced from NO2 to NO which leads to cGMP production which causes vasodilation
how well is nitro absorbed
well, but high 1st pack effect
best route for Nitro
sublingual tablet or spray
toxcicity
headache
major nitro interactions
viagra
nitro special consideration about use
tolerance can develop quickly so need breaks
aspirin therapeutic class
analgesic anti-inflam antiplatelet antipyretic prevention of MI
aspirin pharmacodynamics
COx-1 and Cox-2 inhibitor so decreased platelet aggregation
aspirin oral absoprtion
60%
aspirin half life
3-4 hours
aspirin duration
4-24 hours
how is aspirin excreted
mostly as salicylate metabolites in urine
aspirin toxicity (3)
GI tract ulcers
bleeding disorders
tinnitus
aspirin interactions (2)
inhibits methotrexate and potentiates bleeding from warfarin
avoid aspirin in which patients
nasal polyps and asthma
Clopidogrel pharm class
inhibitor of ADP induced platelet aggregation
Clopidogrel pharmacodynamics
irreversible inhibition of ADP receptors which prevents platelet aggregation
Clopidogrel what is more active pure drug or metabolite
metabolite
how is Clopidogrel absorbed (qualitatively)
well
Clopidogrel onset
1-2 hours
where is Clopidogrel metabolized
liver
Clopidogrel half life
8h
Clopidogrel interactions
may inhibit CYP3A
Abciximab pharmacodynamics
noncompetitive inhibitor of GP IIb/IIIa receptor so prevents binding of fibrinogen, vWF and other ligands needed to activate platelets
how is Abciximab administed
IV bolus followed by IV infusion
Abciximab half life
30 min
Abciximab effect on bleeding time when discontinued
declines
when is Abciximab contraindicated
aneurysm, AV malformation, bleeding, coagulopathy, GI bleed, intracranial mass
N2O
nitrous oxide
NO2
nitrite
NO3
nitrate
NO
nitric oxide
what drug is contraindicated for prinzmetal angina
Beta blockers
