Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Anti-Hypertensives > Flashcards

Anti-Hypertensives Flashcards

1
Q

Hydrocholorthiazide –other drug in class

A

chlorthalidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

cost of hydrocholorthiazide

A

$4-50

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

hydrocholothiazide

-pharmaceutical drug class

A

thiazide diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

hydrocholothiazide

-therapeutic drug calss

A

diuretic

anti-HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

hydrocholrothiazide pharmacodynamics

A

blocks reuptake of Cl and Na from tubular fluid after glomerular filtration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

hydrochorlrothiazide lower BP by how much?

A

10-50mm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

hydrocholrothiazide bioavailability

A

70%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

hydrocholrothiazide half-life

A

short/hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

is hydrocholrothiazide available IV?

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

hydrocholrothiazide onset

A

2h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

hydrocholrothiazide peak

A

5h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

hydrocholrothiazide duration

A

10h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

hydrocholrothiazide toxicity with which drug/ what kind of drug toxicity

A

sulfa Abx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

hydrocholrothiazide - negative effects of diuresis (4)

A

electrolytes depletion
volume depletion
worsens hyperuricemia
metabolic alkalosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

hydrocholrothiazide interactions

A

additive with other anti-HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which population has a lot of side effects with hydrocholrothiazide

A

geriatrics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

hydrocholrothiazide pregnancy class

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

when is hydrocholrothiazide less effective

A

peeps with low GFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Lisinopril cost

A

4-56

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Lisniopril pharm class

A

ACE-I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Lisinopril therapeutic class (5)

A 
antiHTN
preserve renal fxn
preserve LV fxn after MI
acute management of MI
CHF
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Lisinopril pharm dynamics

A

stops conversion of Angiotensin I to A II

decreases vasoconstriction and production of aldosterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

how well is Lisinopril absorbed

A

well

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Lisinopril onset

A

1h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Lisinopril peak

A

6h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Lisinopril duration

A

24h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Lisinopril excretion

A

excreted in urine primarily unchanged

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Lisinopril toxicity can lead to

A

orthostatic hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Lisinopril used with caution in

A 
impaired renal fxn
renal artery stenosis
on other diuretics
aortic stenosis
cough
renal failure
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Lisinopril interactions (3)

A

additive w/ other anti-HTN
NSAIDS may reduce ability to reduce BP
hyperkalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Lisinopril problems w/ pregnancy

A
  • abnormal cartilage

- class c/d

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Losartan brand name

A

CoZaar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Losartan cost

A

4-74

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Losartan pharm class

A

ARB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

which receptor do ARBs act on

A

Angiotensin 1 receptor

36
Q

Losartan therapeutic class

A

antiHTN
preserve renal fxn
treat CHF

37
Q

Losartan pharm dynamics

A

blocks AT-1 receptor so reduces vasoconstriction and aldo production

38
Q

Losartan bioavailability

A

30%

39
Q

Losartan onset

A

6h

40
Q

relationship b/w Losartan and the liver

A

extensive first pass effect

active metabolite is 40x more active

41
Q

Losartan half life

A

long

42
Q

Losartan special considerations

A

renal artery, mitral, or aortic stenosis

patients on diuretics

43
Q

Nitroprusside pharm class

A

vasodilator

44
Q

Nitroprusside pharmacodynamics

A
  • acts directly on vascular smooth muscle to cause dilation of both veins and arterioles
  • metabolized to release CN and NO which activates guanylate cyclase and leads to production of cGMP from GTP
45
Q

Nitroprusside route

A

only IV

46
Q

Nitroprusside onset and duration

A

rapid

47
Q

Nitroprusside metabolized in kidney or liver? What happens after metabolism?

A

liver

Cn to turned SCN and excreted in urine

48
Q

Nitroprusside toxicity

A

accumulation of CN- and thiocyanate
head ache
decreased BF to brain

49
Q

Hydralazine brand name

A

apresoline

50
Q

Hydralazine cost

A

4

51
Q

Hydralazine pharm class

A

vasodilator

52
Q

Hydralazine pharmacodynamics

A

induces production of cGMP

53
Q

Hydralazine is metabolized where

A

GI mucosa and liver

54
Q

big toxicity issue with Hydralazine

A

drug induced lupus

55
Q

Hydralazine special considerations

A

never use as chronic monotherpahy b/c of edema and reflex tachy

56
Q

Amlodipine brand name

A

Norvasc

57
Q

Amlodipine cost

A

4

58
Q

Amlodipine pharm class

A

dihydropyridine CEB

59
Q

Amlodipine therapeutic class

A

antiHTN

anti anginal

60
Q

Amlodipine pharm dynamics

A

reduces by by inhibiting influx of Ca through slow channels, so peripheral arterioles dilate
negative inotropic effects
reduces after load
reduces O2 consumption inhibits spasm

61
Q

Amlodipine bioavailabilty

A

64-90%

62
Q

Amlodipine duration

A

24 hours

63
Q

Amlodipine is metabolized where?

A

liver

64
Q

Amlodipine is excreted how

A

90% in urine as inactive metabolite

65
Q

amlodipine toxicity

A

AV block

aortic stenosis, CHF

66
Q

Amlodipine interactions

A

toxic effect on the heart when given with BB

67
Q

Amlodipine pregnancy class

A

C

68
Q

Clonidine other drugs in class

A

methyl dopa

69
Q

Clonidine cost

A

4-37

70
Q

Clonidine pharm class

A

alpha 2 adrenoreceptor agonist

71
Q

Clonidine therapeutic besides hTN

A

opiod withdrawl

migraine

72
Q

clonidine pharm dynamics

A

activates a2 receptors in CNS and leads to decreased sympathetic tone

73
Q

clonidine bioavailability

A

F~85%

74
Q

clonidine onset

A

1h

75
Q

clonidine duration

A

8H

76
Q

is clonidine associated w/ rebound HTN

A

yes..so wean off

77
Q

trimethaphan drug class

A

ganglionic transmission blocker

78
Q

trimethaphan pharmacodynamics

A

blocks nictone transmission in all ANS ganglia so decreases sympathetic tone

79
Q

reserpine pharmcodynamics

A

binds to vesicles containign NE or serotinin and prevent their uptake/release

80
Q

diabetics 1st line anti HTN drug of choice

A

ACE-I

81
Q

Post MI anti HTN drug of choice

A

BB

82
Q

CHF anti HTN drug of choice

A

ACEI or beta blocker

83
Q

Afib antiHTN drug of choice

A

CEB

84
Q

Pregnancy anti-HTN drug of choice

A

methyldopa and labetalol

85
Q

methyldopa drug class

A

a2 receptor agonist

Pharmacology (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions