Respiratory Flashcards
What is type 1 respiratory failure
Involves hypoxaemia <60mmHg with normocapnia PaCO2 35-45mmHG
Example: APO
What are the causes of a type 1 respiratory failure
V/Q mismatch; the volume of air flowing in and out is not matched with the flow of blood to the lung tissue
COPD, APO, pneumonia
What is type 2 respiratory failure
Involves hypoxaemia PaO2 <60mmHg with hypercapnia >45mmHg. Occurs as a result of alveolar hypo ventilation which prevents the patient from being able to adequately oxygenate and eliminate CO2 from their blood
What is shunting
Hypoxaemia caused by inadequate ventilation of well perfumed areas of the lung. Occurs in atelectasis, in asthma as a result of bronchoconstriction, pulmonary oedema, and pneumonia when alveoli are filled with fluid.
What are the most common causes of V/Q mismatch
Asthma, COPD, Fibrosis, Pneumonia, pulmonary HTN, PE
Shunt
When blood is transported through the lungs without taking part in gas exchange
What is anatomical dead space?
The air in the “conducting zone” of the airways that don’t participate in gaseous exchange.
What are the clinical manifestations of hypoxia
Confusion, anxiety, tachycardia, tachypnoeic, diaphoretic, restlessness, cyanosis
Define hypercapnia
Increased CO2 in arterial blood caused by hypo ventilation
Clinical manifestations of hypercapnia
Respiratory acidosis - electrolyte abnormalities occur in response to a low pH that can cause arrhythmias.
Sleepy ,Drowsy, Coma - due to changes in intracranial pressure associated with high levels of arterial carbon dioxide which causes cerebral vasodilation
Causes of respiratory failure type 2
Increased resistance as a result of airway obstruction (COPD)
Reduced compliance of lung tissue/chest wall ( pneumonia, rib fractures, obesity)
Reduced strength of the respiratory muscles (guillian-barre, MND)
Drugs acting on the respiratory centre reducing overall ventilation (opiates)
Indications for NIV
Respiratory failure type 2
Gives a push behind each breath and creates positive pressure
COPD with respiratory acidosis pH<7.35
Pneumonia
Hypercapnic respiratory failure secondary to chest wall deformity or neuromuscular
Weaning off tracheal intubation
Indications for CPAP
Respiratory failure type 1
Creates positive pressure in the lungs- preventing alveoli from collapsing.
Hypoxia in the context of chest wall trauma
Cardiogenic pulmonary oedema
Pneumonia: as an interim measure before invasive
Congestive heart failure
Obstructive sleep apnoea
* increases gas exchange by recruitment of alveoli
Contraindications for CPAP/BiPAP
Vomiting/ excess excretions Confusion/agitated Altered conscious state Bowel obstruction Facia burns/trauma Recent facial trauma Inability to protect own airway Pneumothorax (untrained)
Oxygen toxicity symptoms
Nausea, vomiting Anxiety Visual changes Hallucinations Dry cough Substernal chest pain Sob Pulmonary oedema Vertigo Hiccups Seizures