RESPIRATORY Flashcards
At what spine level does the trachea bifurcate
T4
What is the lung segmentations after the bronchi divides
Lobar bronchi, segmental bronchi, terminal bronchioles, respiratory bronchi, alveolar ducts, sacs
What are the main muscles of inspiration
Diaphragm and external intercostals
what nerve supplies the diaphragm
the phrenic nerve - c3,4,5
What are the fissures on the right lung called
The horizontal and oblique fissure
how many fissures do the right and left lung have respectively?
2 and 1
what is the left lung fissure(s) called
the oblique
what are the pleural layers called
the parietal and visceral. visceral is on the organ side and parietal is on the outside
What are the structures in the upper airways
Nasal passage, larynx, trachea, lobar bronchi down to terminal bronchi
what are the structures in the lower airway
respiratory bronchioles to alveolar sacs
what is respiratory epithelium
Pseudostratified ciliated columnar epithelium with interspersed goblet cells
What is the mechanics of inspiration
Phrenic causes diaphragm to contract and it moves down, as well as external intercostals contracting. this increases the thoracic pressure and lowers the pressure. the chest wall and ribs move up and out and the oxygen moves in down the pressure gradient
what are the muscles of forced inspiration
the sternocleidomastoid, the serratus anterior and the latissimus dorsi
what happens during expiration
it is normally a passive process, there is decreased phrenic input to the diaphragm and external intercostals which causes them to relax. this causes a decrease in volume and an increase in pressure in the thorax. the alveoli compress and the air passively moves down the gradient
what are the accessory muscles for forced expiration
the internal intercostals and the abdominal muscles
what is the transpulmonary pressure
the difference between the alveolar and interpleural pressure, normally about 4mmHg
what happens if the transpulmonary pressure is 0mmHg
you would get a pneumothorax
what are the two main respiratory centers in the brain
the pontine and medullary centers
what are the pontine centers of respiration and what is their function
the apneustic center which fine tunes the inspiratory stimulus and acts on the DRG to cause inspiration
the pneumotaxic center is involved in the smoothing the transition to expiration and acts on the VRG
What are the medullary centers of respiration
the VRG (ventral respiratory group) and the DRG (dorsal respiratory group)
what are the different types of receptor found in the lungs
Slow adapting stretch receptors, rapid adapting stretch receptors, J receptors and chemoreceptors
What is the function of slow adapting stretch receptors
they respond to distension and end inspiration to prevent overstretch of the lungs
what is the function of rapid adapting stretch receptors
they are between the airway epithelium and they respond to irritants - bronchoconstriction
what is the function of J receptors
the are across the capillary wall and respond to an increase in lung pressure due to a build up of fluid. they will increase the respiratory rate to induce rapid shallow breathing
where are peripheral chemoreceptors found?
in the aortic arch and in the carotid sinus (bifurcation)
what does the peripheral chemoreceptors detect
they detect changes in pressure of oxygen (activated about 60% saturation) and also H+ ion concentration
where are the central chemoreceptors found
in the medulla
what do the central chemoreceptors detect
they look at the partial pressure of carbon dioxide, very important for the respiratory drive
how to peripheral chemoreceptors detect carbon dioxide
carbon dioxide crosses the blood brain barrier and reacts with water. this becomes H2CO3. this then dissociates into HCO3- and H+ which is then detected by the chemoreceptors
where is more perfused, top or bottom of the lung
the bottom of the lung, due to gravity. this means the V/Q is lower at the bottom of the lung
what is a dead space in the lungs
when there is ventilation but not perfusion, which causes a HIGH V/Q
what is a shunt in the lungs
when there is no ventilation but there is perfusion. there is a low V/Q value here
what happens when there is a dead space in the lungs
there is local bronchoconstriction which causes air to be diverted to areas which are better perfused
what happens when there is a shunt in the lungs
there is hypoxic pulmonary vasoconstriction, blood is directed to better ventilated areas
what happens if the oxygen dissociation curve moves to the right
it means that there is a lower affinity and therefore a higher level of dissociation
what happens if the oxygen dissociation curve moves to the left
the more left then the higher affinity and the more binding
what factors may cause a left shift of the oxygen dissociation curve
higher pH, decrease in CO2, lower temperature and lower DPG. also carbon monoxide and foetal haemoglobin
what causes the oxygen dissociation curve to move to the right
low pH, increased CO2, increase in temperature and increase DPG
how is carbon dioxide transported in the blood
dissolved in the plasma (10%), bound to hemoglobin in the form of carbaminohemoglobin (23%), and as HCO3- (65%)
What does hypoventilation cause
increase CO2, increase H+, induce respiratory acidosis
what does hyperventilation cause
decrease in CO2, therefore decrease hydrogen and causes respiratory alkalosis
what is the carbonic acid equation
CO2 + H2O - (carbonic anhydrase) - H2CO3 - H+ + HCO3-
What is Daltons equation
PT = ppA + ppB + ppC etc
pressure exerted by mixture of gases are equal to the pressure of the equal parts
what is boyle’s law
P1V1 = P2V2
P proportional to V
what is henrys law
volume of gas dissolved in a liquid depends on the partial pressure and solubility of it
What is Ohms law
V=IR
pressure = flow X resistance
what is the alveolar gas equation
PAO2 = PiO2 - PaCO2/R
where R=0.8
what is Laplace’s law
P = 2T/R
alveoli pressure depends on the surface tension and radius. On alveoli its reduced by surfactant
what is compliance
greater compliance means the greater ability for the lungs to expand. it is dependent on surface tension and elasticity of the lung
what are the most common causes of hypoxia
hypoventilation increasing PaCO2, diffusion impairment (thickening of a membrane), shunt and V/Q mismatch
what is type 1 respiratory failure
low/normal PaCO2, low PaCo2
what is type 2 respiratory failure
low PaO2, high PaCO2
what is the laryngopharynx
hyaloid and then cricoid cartilage. the epiglottis is elastic
how many vocal cords do you have
you have two vocal cords and one false set of vocal cords
what epithelium is in the epiglottis
upper part is stratified squamous and lower is respiratory epithelium
what is the anatomical and physiological dead space
the anatomical dead space is the air in the conducting zone. the physiological dead space is the anatomical plus the alveoli dead space
what is FEV1
it is the forced expiratory volume in one second
what happens when you have airway obstruction
FEV1 is reduced more than the FVC. the FEV1/FVC ratio is less than 0.7. this occurs in COPD and asthma
what happens in airway restriction
both the FEV1 and FVC is reduced equally. the ratio is normal. this occurs in pulmonary fibrosis and muscular failure
how do airways constrict
parasympathetic - Ach binds to the M3 muscarinic receptors and causes bronchoconstriction
what causes airways to dilate
adrenaline and noradrenaline binds to B2 adrenoreceptors and causes dilation
what is type 1 hypersensitivity
IgE - hay fever
what is type 2 hypersensitivity
autoimmune, IgG mediated
what causes type 3 hypersensitivity
the complement system and immune complex formation. hypersensitivity pneumonitis
what is type 4 hypersensitivity
T cell mediated in the form of granulomas. sarcoidosis
what causes anaphylaxis
the first exposure causes IgE to be sensitized and presentation of past cells. the second time IgE binds to a high affinity receptor on mast cells which then degranulates releasing histamine and tryptase. this causes low blood pressure, difficulty breathing and swelling of upper airway
what is the fetal lung circulation
the lungs are not used in utero, as there is high pressure. there is the ductus venosus to the inferior vena cava, the foramen ovale allows for shunting between the right and left side of the heart
what happens during the first breath
the fluid in the lungs is expelled, the pressure drops and the lungs open, the pulmonary circulation takes over and the foramen ovale closes
how does aging affect the lung
decreased chest compliance, thorax changes shape (increased curvature), decreased respiratory muscle strength, decrease in elastic recoil, impaired gas exchange, impaired immunity
describe the bronchiole circulation
there is a thick wall, there is pressure of 120/80.
O2 causes vasoconstriction and hypoxia causes vasodilation. there is delivery of oxygen to the lung tissue.
there is redistribution of the blood
describe the pulmonary circulation
there are thin walls with a pressure of 25/8. oxygen causes vasodilation and hypoxia causes vasoconstriction. it picks up oxygen
what the pulse pressure
it is the difference between the systolic and diastolic pressure
what does Poiseuille’s law relate to
resistance is inversely proportional to the radius^4
there is a small decrease in radius leads to a large increase in vascular resistance
what does PEF stand for
peak expiratory flow
what is FEV1
it is the forced expiratory volume in one second
what is FVC
forced vital capacity - total expiratory volume that we have
what happens in lung obstruction
the FEV1/FVC is less than 0.7. this occurs when there is a block, in COPD and asthma.
there is a reduction of FEV1, but the FVC stays the same
what happens in lung restriction
the FVC is less than 0.8. there is a decreased expiratory volume (lung is filling less), this occurs in pulmonary fibrosis
what does IRV stand for
maximal inhalation excess of normal inspiration
what does ERV stand for
the maximal exhalation excess of normal
what does TV stand for
tidal volume - this is just normal breathing
what does RV stand for
residual volume
this is the air left after maximal expiration