CARDIOVASCULAR Flashcards
what is plasma
translucent liquid component of the blood that holds the cellular components of blood in a suspension
about 90% water, 7% carrier proteins and the rest is electrolytes, hormones gases and nutrients
what is serum
plasma without the clotting factors
what are red blood cells
they are erythrocytes, which are anuclear, and are important for the carrying of oxygen around the body
what is the lifespan of a RBC
about 120 days
what are the different types of leukocytes and their groupings
monocytes, lymphocytes, basophils, eosinophils, neutrophils
monocytes and lymphocytes are agranular and basophils, eosinophils and neutrophils are granular
what are the granulocytes
neutrophils, eosinophils and basophils
what is the most abundant leukocyte
neutrophils
what are neutrophils function
they are the first line of defense and phagocytose pathogens, they are part of the innate immune response
what is the function of eosinophils
combats parasite infections and neutralises histamine
what is the basophil function
they produce histamine - responsible for anaphylaxis
what are the agranulocytes
monocytes and lymphocytes
what is the function of monocytes
monocytes in the blood and macrophages in the tissue. they phagocytose foreign material - examples are kupfer cells, microglial cells
what is the function of lymphocytes
they are part of the adaptive immune system, T cells, B cells and natural killer cells. they produce antibodies and attack cells, as well as activating other parts of the immune system
what are platelets
they are anucleate cells that become spiculated which they are activated. they form a platelet plug to prevent damage to underlying cells during vessel wall damage
what is hemostasis
process to prevent and stop bleeding
what happens during vessel injury
in vessel injury there is endothelium exposure and endothelin release. this causes vasoconstriction. you then get adhesion of platelets to the subendothelial collagen via vWF using receptor GP1B. once the platlets bind there is activation inducing a shape change. the platelets release their alpha and dense granules containing vWF, thromboxane A2, fibrinogen and fibrin stabilizing factor, and ADP, CA2+ and serotonin respectively. this release causes aggregation of further platelets
what are the different parts of the coagulation cascade
there is an intrinsic and extrinsic pathway, with the most important aspect being fibrin
how does the common pathway work
fibrinogen is in the blood and in the inactive form. it requires thrombin to be active. through the coagulation cascade prothrombin is converted to thrombin. this then converts fibrinogen into fibrin
what are important factors in the coagulation cascade
IIa (thrombin), Ia(fibrin), XIIIa (fibrin stabilizing factor), IV (Ca2+)
what are the vitamin K dependent factors
X, IX, VII, II
what does warfarin do
warfarin inhibits the vitamin K dependent clotting factors
what is the fibrinolytic pathway
this is plasmin mediated fibrin breakdown. plasminogen is activated into plasmin by factor X. this then degrades fibrin
what is required before a blood transfusion occurs
cross matching to see if the donors blood is safe for the recipient
what are the 4 main blood groups
A, B, AB and O
how is membrane potential in a cardiac myocyte maintained
it is maintained by the sodium potassium pump (as well as smaller diffusion channels)
what is the cardiac myocyte cycle
in depolarisation there is an influx of sodium into the cell, and this causes the membrane potential to increase. once it reaches -60mV this causes depolarisation and more sodium channels to open. at 30mV sodium channels close and there is partial repolarisation. there is then the plateau phase as L type calcium channels are open and allow for influx of calcium into the cell, which balances to potassium efflux. there is then repolarisation, as the calcium channels close and there is a net movement of potassium out of the cell
what is the absolute refractory period
the cell can not be excited again no matter the stimulus
what is the relative refractory period
where the threshold potential is higher, but you can cause depolarisation with a strong stimulus
what is pacemaker potential
the pacemaker potential is responsible for the automaticity of the heart, which is generated by nodal cells. the primary pacemaker is the SAN
what happens when there is sympathetic stimulation of the SAN
noradrenaline increases the calcium channel opening, which causes a steeper depolarisation, increasing the heart rate and the force of contration
what happens when there is parasympathetic activity on the SAN
this is via the vagus nerve, this decreases the heart rate. Ach activated the potassium channels which hyperpolarises the membrane
what is excitation-contraction coupling
this is when calcium moving into the cell binds onto the ryanodine receptor on the SR and releases more intracellular calcium. this calcium binds onto troponin on the myofilaments which uncovers the binding site for actin on the tropomyosin strand.
in an ECG, what is a lead
a lead is the plane in which you are looking at the heart
in ECG what is an electrode
an electrode is what you place on a body to pick up electrical signals
in EGC where is lead 2 placed
from the right arm to the left leg
how many leads are looked at on an ECG
12
what is lead 1 placed in ECG
from the right arm to the left arm
where is lead 3 placed in an ECG
left arm to the left leg
what are the three unipolar leads in ECG
aVR, aVL and aVF
where are the 6 chest leads places
lead V1 - 4th intercostal space to the right of the sternal border
lead V2 - the 4th intercostal space to the left of the sternal border
lead V3 - midway between V2 and V4
lead V4 - 5th intercostal space, midclavicular line
lead V5 - anterior axillary line at the same level as V4
lead V6 - mid axillary line at the same level as V4 and 5
what does the initial two heart tubes develop from
the visceral mesoderm
then do the 2 primitive heart tubes fuse
during lateral folding
what are the primitive heart tube divisions
the truncus arteriosus, the bulbus cordis, the primitive ventricle, the primitive atrium and the sinus venosus
what does the truncus arteriosus become
the ascending aorta and the pulmonary trunk
what does the bulbus cordis become
the smooth parts of the left and right ventricles
what does the primitive ventricle become
forms the majority of the ventricles
what does the primitive atrium become
the entire left atrium and the anterior part of the right atrium
what does the sinus venosus become
the smooth part of the right atrium, the venal canal and the coronary sinus
what is the process of septation in embryology
the formation of the left and the right heart
the tube folds and pinches
what does the first aortic arch become
becomes the maxillary artery
what does the second aortic arch become
becomes the stapedial and hyoid artery
what does the third aortic arch become
the common carotid - part of the internal carotids
what does the fourth aortic arch become
branches. the left becomes the aortic arch and the right becomes the right subclavian
what happens to the fifth aortic arch
it regresses and doesnt become anything
what happens to the sixth aortic arch
it becomes the pulmonary arteries, and the left becomes the ductus arteriosus
when does the heart appear in utero, and when does it start beating
it appears in the third week and begins beating on day 23
describe the cardiac cycle
starts with ventricular systole. there is isovolumetric contraction where the ventricles contract, with all valves closed and the pressure increases. the pressure continues to increase until it is above the aortic pressure. the aortic valve opens and the blood is forced into the aorta. as this happens the ventricular pressure reduces, eventually below the aortic and the valve will shut. this again causes a closed system. the atria fills with blood and contracts, its pressure rising above ventricular pressure. this causes the atrioventricular valve to open and blood to flow into the ventricle and the cycle starts again
what is the end diastolic volume
this is the volume of blood in the ventricles before contraction
what is the stroke volume
the amount of blood that is pumped out during ventricular systole (~70%)
what is the ejection fraction
ejection fraction is the stroke volume divided by the end diastolic volume
what factors effect stroke volume
preload, afterload and contractility
what is preload
preload is the same as the end diastolic volume. the larger the preload the larger the stroke volume
what factors can effect preload
atrial contractility, venous return, ventricular compliance, valvular resistance and the heart rate
what is contractility
the force of contraction that the heart beats with. can increase contractility via the sympathetic nervous system
what is afterload
afterload is the amount of pressure that the heart needs to exert to eject the blood during ventricular contraction. it is affected by valvular disease, aortic pressure and resistance
what is resistance to blood flow related to
its directly proportional to the viscosity and the length, and inversely proportional to the radius of the vessel to the 4th power
what is intrinsic control of resistance
myogenic autoregulation. an arteriole regulates its own blood pressure based on stretch. there are local mediators which can vasoconstrict and dilate.
constrictor - endothelin
dilators - prostacyclin, hypoxia, tissue factor, nitric oxide
what is extrinsic control or resistance
hormones
vasoconstrictors = adrenaline acting on alpha receptors, angiotensin II and vasopressin.
Vasodilators = adrenaline actin on beta 2 receptors
what are baroreceptors
the detect pressure changes
where do baroreceptors talk to
they feed impulses via CN 9 and 10 to the medulla oblongata
what are the separations of the mediastinum
divided into superior and inferior by the sternal angle. the inferior is then separated into the anterior, middle and posterior
what structures are present in the muddle mediastinum section
the heart, aorta, vena cava, trachea, vagus and phrenic nerve
what is the pericardium
the pericardium is a fibro serous sac that surround the heart.
the outermost layer is fibrous, the serous layer is divided into the parietal and visceral layer.
the visceral layer contains vessels and nerves.
what are the borders of the heart
right - right atrium
the inferior - left and right ventricle
left - the left atria and some of the left ventricle
superior - left and right atria and great vessels
how does the heart receive a blood supply
when the aortic valve closes the cusps fill with blood when then supplies the left and right carotid arteries. the heart gets perfused during diastole
what are the divisions of the right coronary artery
the right coronary has two branches the right marginal and the right posterior interventricular artery.
what does the right marginal artery supply
the right marginal supplies the right ventricle including the SAN
what does the posterior interventricular artery supply
the posterior 1/3 of the interventricular septum and the AVN (in 60% of people)
what does the left coronary artery divide into
the left anterior descending, the left marginal and the circumflex.
what does the left anterior descending artery supply
the LAD supplies 2/3 of the interventricular septum and the right and left ventricle
what does the left marginal artery supply
the left ventricle
what does the circumflex artery supply
it supplies the left atrium and the left ventricle