Reproductive System Flashcards

1
Q

Lobule

A

Made of small ducts

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2
Q

Non-neoplastic conditions (2)

A
  1. Fibrocystic changes (hormonally driven)

2. Inflammatory conditions

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3
Q

Fibrocystic changes

A

Hormonally driven
Fibrosis -cystically dilated ducts
Pre-menopausal young adults
Very common

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4
Q

Acute mastitis

A

Inflammatory condition
Lactating women
Can lead to abcess

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5
Q

Fibroademona

A
Benign tumors
20-30yo
Often self-detected lump
Biphasic tumors
Taken out surgically
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6
Q

Biphasic tumors

A

Epithelial proliferation and stromal proliferation

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7
Q

Carcinoma of the breast

A

Most common malignant tumor in women (1/9)
Rises from epithelium of breast ducts and lobules
Can metastasize

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8
Q

Ductal and lobular carcinoma in situ

A

Precursor lesions
Proliferation of cancerous cells limited to the duct
No invasion through basement membrane - cannot metastasize

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9
Q

Risk factors of breast cancer

A
Female > male
Family history, genes
White>African>East Asians
Post-menopausal women
Estrogen excess
Non-malignant proliferative breast changes
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10
Q

How is breast cancer diagnosed?

A

Self detection
Mammographic screening
Distant metastasis
Breast biopsy

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11
Q

Prognosis in breast cancer

A

Stage, tumor type, grade, ER/PR/HER2 status (treatment potential)

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12
Q

Breast cancer metastases

A

Most common site is to regional lymph nodes of the axilla

Can distantly metastasize to brain, liver, lung, bone

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13
Q

Tissue tupe of vulva, vagina, exocervix

A

Squamous epithelium

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14
Q

Tissue type of endocervix

A

Glandular epithelium

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15
Q

Tissue type of myometrium

A

Smooth muscle

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16
Q

Tissue type of endometrium

A

Glandular epithelium

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17
Q

Tissue type of fallopian tubes

A

Ciliated, tubal epithelium

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18
Q

Follicles

A

Contained in ovaries

Oocytes and sex cord cells

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19
Q

Ovaries

A

Connective tissue stroma, oocytes and sex cord cells

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20
Q

Hormonal regulation of female reproductive system

A

Hypothalamic-pituitary-ovarian axis

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21
Q

Hypothalamus secretions

A

Secretes GnRH

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22
Q

Pituitary secretions

A

Secretes FSH and LH

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23
Q

Ovarial follicle secretions

A

Secretes estrogen - ovulation

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24
Q

Corpus luteum secretions

A

Secretes estrogen and progesterone

25
Q

Follicular phase

A

Characterized by rising estrogen

26
Q

Luteal phase

A

Characterized by rising estrogen and progesterone

27
Q

Phases of endometrium

A

Proliferative, secretory, menstrual (shedding)

28
Q

Bacterial infections (4)

A
  1. Neisseria gonorhea
  2. Tremponema pallidum (syphilis)
  3. Streptococcus and staphylococcus
  4. Chlamydia trachomatis
29
Q

Viral infections (2)

A
  1. Genital herpes

2. HPV

30
Q

Fungal infections

A

Candida albicans (yeast infection)

31
Q

Pelvic inflammatory disease

A

Upper gynecologic tract
General term to describe inflammation/infection that ascends from lower to upper genital tract
Polymicrobial: chlamydia, gonorrhea, others
Causes inflammation, abscess formation, scarring
Can have no symptoms, pain, fever, infertility

32
Q

Endometriosis

A

Foci of endometrium found outside uterus
Most often located on ovary, pelvic peritoneum, fallopian tube, vagina
Retrograde menstrual flow
Causes cyclic pain, infertility

33
Q

Uterine fibroid

A

Very common neoplasms of smooth muscle

34
Q

Squamous cell carcinoma

A

Vulva, vagina, cervix

Many are HPV related

35
Q

Leiomyoma

A

Benign tumor of the myometrium - smooth muscle

36
Q

Tumors of the uterus (2)

A
  1. Endometrium: carcinoma

2. Myometrium: leiomyoma

37
Q

Tumors of the ovaries (3)

A
  1. Tumors of surface epithelium
  2. Germ cell tumors
  3. Sex cord stromal tumors
38
Q

Tumors of fallopian tube

A

Carcinoma

39
Q

Human Papilloma virus

A

Variety of pathologies (depending on virus type)
Infection, sometimes neoplasia
High and low risk

40
Q

Low risk HPV

A
6 + 11
Condyloma accuminatum (warts) and low risk lesions
41
Q

High risk HPV

A

16 + 18
Premalignant lesions of cervix, vulva, vagina, anus, penis
Invasive squamous cell carcinoma

42
Q

Diagnosis on pap (5)

A
  1. Negative
  2. Atypical cells of undetermined significance
  3. LSIL
  4. HSIL
  5. Carcinoma
43
Q

Colposcopy

A

In the event of an abnormal pap

To visualize cervix for biopsy

44
Q

Endometrial adenocarcinoma

A

Related to hyperestrinism - obesity, hormone replacement therapy
May be preceded by endometrial hyperplasia
Occurs in perimenopausal, postmenopausal women

45
Q

Solitary cysts (2)

A
  1. Follicular cysts

2. Corpus luteum cyst

46
Q

Polycystic ovary syndrome (POS)

A

Associated with hormone disturbances, menstrual irregularities, hirsutism, infertility

47
Q

Tumors of surface epithelium (ovaries)

A

Malignant: serous or mucinous cystadenocarcinoma
Benign: serous or mucinous cystadenoma

48
Q

Germ cell tumors (ovaries)

A
Teratoma
Usually less than 25 yo
Arise from primordial germ cells that migrate from yolk sac in early embryogenesis
Mature embryonic tissues
Occasionally malignant
49
Q

Sex cord stromal tumors (ovaries)

A

Granulosa cell tumor

50
Q

Pregnancy

A

Fertilization (spermatozoa + oocyte in fallopian tube)
Inplantation (zygote implans in endometrium)
Placenta, fetal sac and fetus develop

51
Q

Placenta parts (3)

A
  1. Chorionic villi
  2. Maternal vessels
  3. Amniotic membranes
52
Q

Pathology of pregnancy (3)

A
  1. Fertilization problems
  2. Implantation problems
  3. Placental problems
53
Q

Fertilization problems

A

Abnormal ovum or sperm

54
Q

Implantation problems

A

PID - fallopian tube scarring

Ectopic pregnancy

55
Q

Placental problems (2)

A
  1. Placenta previa

2. Placenta accreta

56
Q

Placenta previa

A

Covers cervical os

Needs C section, bleeding during pregnancy

57
Q

Placenta accreta

A

Penetrates into uterine wall
Into myometrium, and occasionally beyond
Placenta does not separate properly at birth, may cause extensive bleeding and require surgery

58
Q

Ectopic pregnancy

A

Implantation outside of uterine cavity
Fallopian tube > ovary > pelvic peritonium
Often caused by scarring from PID, prior surgery, endometriosis
Pain, or rupture of fallopian tube
Medical emergency