Reproductive System Flashcards
Lobule
Made of small ducts
Non-neoplastic conditions (2)
- Fibrocystic changes (hormonally driven)
2. Inflammatory conditions
Fibrocystic changes
Hormonally driven
Fibrosis -cystically dilated ducts
Pre-menopausal young adults
Very common
Acute mastitis
Inflammatory condition
Lactating women
Can lead to abcess
Fibroademona
Benign tumors 20-30yo Often self-detected lump Biphasic tumors Taken out surgically
Biphasic tumors
Epithelial proliferation and stromal proliferation
Carcinoma of the breast
Most common malignant tumor in women (1/9)
Rises from epithelium of breast ducts and lobules
Can metastasize
Ductal and lobular carcinoma in situ
Precursor lesions
Proliferation of cancerous cells limited to the duct
No invasion through basement membrane - cannot metastasize
Risk factors of breast cancer
Female > male Family history, genes White>African>East Asians Post-menopausal women Estrogen excess Non-malignant proliferative breast changes
How is breast cancer diagnosed?
Self detection
Mammographic screening
Distant metastasis
Breast biopsy
Prognosis in breast cancer
Stage, tumor type, grade, ER/PR/HER2 status (treatment potential)
Breast cancer metastases
Most common site is to regional lymph nodes of the axilla
Can distantly metastasize to brain, liver, lung, bone
Tissue tupe of vulva, vagina, exocervix
Squamous epithelium
Tissue type of endocervix
Glandular epithelium
Tissue type of myometrium
Smooth muscle
Tissue type of endometrium
Glandular epithelium
Tissue type of fallopian tubes
Ciliated, tubal epithelium
Follicles
Contained in ovaries
Oocytes and sex cord cells
Ovaries
Connective tissue stroma, oocytes and sex cord cells
Hormonal regulation of female reproductive system
Hypothalamic-pituitary-ovarian axis
Hypothalamus secretions
Secretes GnRH
Pituitary secretions
Secretes FSH and LH
Ovarial follicle secretions
Secretes estrogen - ovulation