Reproductive Flashcards
dub tx in adolesc
high dose estrogen in acute severe bleed
dub cause in adolesc
diagnosis of exclusion
r/o other pathologic causes but unlikely in younger pt/s
DUB cause in postmenopausal women
More likely pathologic US Hysteroscopy endocervical curetage and bx D&C
Menorrhagia
heavy or prolonged bleeding
Metorrhagia
bleeding between cycles
Menometorrhagia
Irregular cycles w/ heavy/prolonged bleeding
TVUS >___? is indicative of endometrial hyperplasia
4mm
Tx for endometrial hyperplasia w/o atypia
Progestrin (po or IUD)
Repeat bx in 3-6mo
Endometrial hyperplasia w/ atypia tx
TAH +/- BSO
What is the most common gyn Malignancy in the US
Endometrial ca
endometrial stripe >4mm indicates what
Endometrial hyperplasia
Endometrial ca
Tx for Stage 1 Endometrial ca
TAH +/- BSO
Tx for stage 2 endometrial CA
TAH + BSO, lymph node excision, post-op rad
MC bening gyn lesion
Leiomyoma
What population is mc in leiomyoma
African American (5X more common)
Pelvic us sign of leiomyoma
“Pelvic shadowing”
Tx for leiomyoma
Usually nothing - majority don’t need tx
Medical tx: Progestin, Leuprolide (GnRH inhib),
Surgical: Myomectomy, Ablation, Hysterectomy is definitive tx.
Define Endometritis
Infection of endometrium during pregnancy
MC pathogen of endometritis
GABHS, S. aureus
What is endometritis called if the pt is not pregnant?
PID
MC cause of endometritis
retained products of conception (mc w/ c-section)
Infection after c-section tx w/
Clinda and gent
Infection after vag delivery or chorioamnionitis
Amp and Gent
Classic triad of endometriosis
- Cyclic premenstrual pelvic pain
- dysmenorrhea
- Dyspareunia
Defintive dx of endometriosis
Laparoscopy w/ bx
What is a “chocolate cyst”
Endometrioma
Medical tx of endometriosis
Ovulation suppresion 1. Pain: OCPS + NSAIDS 2. Prog tx: suppress GnRH, 3. Leuprolide 4. Danasol Surg: 1. Cons laparoscopy w/ ablation 2. TAH BSO
Uterine prolapse
Uterine herniation into vagina
Cystocele
Post. bladder herniating into ant vag wall
Enterocele
Pougch of Douglass (sm bowel) into the upper vagina
Rectocele
Distal Sig colon (rectum) into the posterior distal vagina
Grade 1: Pelvic organ prolapse
Descent into upper 2/3 of vagina
Grade 2 Pelvic organ prolapse
Cervix approaches introitus
Grade 3 Pelvic organ prolapse
Outside introitus
Grade 4 Pelvic organ prolapse
Entire uterus outside of vagina - complete prolapse
Dx of funcitonal ovarian cyst
Pelvic US
MC tx for ovarian cysts
<6-8 cm functional and usually spontaneously resolve
Most concerning complication of ovarian cyst
torsion
Medical tx for ovarian cyst
OCP’s
What is the 2nd MC gyn cancer?
Ovarian Ca
What gyn cancer has the highest mortality rate?
Ovarian ca
Sister mary joseph node
Mets to umbilical LN (from ovarian ca)
In reproductive age what % of ovarian neoplasms are benign?
90
PCOS traid
Amenorreha, hirsutism, and Obseity (insulin resistance)
Labs for PCOS
Inc testosterone, Inc LH:FSH ratio,
TX of PCOS
OCP’s (mainstay) to normalize bleeding and tx hirsutism,
Anti-andronergic agents for hirsutism-Spironolactone
Infertility tx: Clomid
Lifestyle changes
Surgical
routine pap screen
Start at age 21 q2y until age 29
age 30 q3-5y if hx of 3 neg cytology
Yearly HIV
stop at age 65-70
If age >25 w/ + HPV what are the two options
- Cyt and HPV tesiting in 12mo
OR - Genotype for HPV 16,18
ASCUS + > 25yo follow up
- HPV testing if neg repeat w/ cotest q3y or HPV testing + –> colopscopy w/ b
OR - Repeat Pap in 1 year if neg resume Pap if pos Colpo
21-24 ACUS or LSIL f/u
Repeat pap in 1 y or HPV testing
<21 ASCUS f/u
Repeat Pap in 1 year
ASC-H F/u
Colposcopy
LSIL 25-29 f/u
Colpo q/ BX
LSIL >30yo f/u
HPV neg –> repeat cytology in 1 year
HPV + –> Colpo w/ bx
What CIN grade is LSIL assoc. w/
CIN1
HSIL f/u
Colpo w/ bx in all ages
HSIL CIN grade assoc.
CIN II, III, and CA in situ
TX for CIN1
Obs. (75% self resolve).
LEEP, or conization
Tx for CIN2 & 3
EXcision and ablation mainstay of TX for CIN 2 and 3.
MC etiology for cervical ca
HPV (99.7%) esp, 16,18, 31, 33
Is smoking protective or a risk factor for Cervical CA?
Risk
MC type of cerv. ca.
Squamous
1st sing of cervical ca?
poscoital bleeding/spotting
Define incompetent cervix
cervical dilation esp in 2nd trimester
Is vaginal cancer rare or common?
Rare Less than 1%
What risk factor exists for Vag ca?
DES exposure
MC presentation of vulvar ca
Pruritis
Dx of vulvar ca
Red/white ulcerative, crusted lesions
Etiologies of vaginitis
ID: BV, Trich, Candida, Cytolytic
Atrophy: post menopause, allergies
Tx for vulvovaginal atrophy
Creams
Ospemifene
moisturizers
BV D/c
Thing, homogenous, watery, grey-white “rotten fish” smell
BV Microsocopic
Clue cells
Few WBC’s
TX for BV
Metronidazole
Clinda
Trich d/c
Frothy yellow green
Strawberry cervix
Trich micro
Mobile protozoa on wet mount
WBC present
Tx of Trich
Metronidazole
Tinidazole
Candida d/c
Thick, curdlike/cottage ch
Candida micro
Hypae, yeast, on KOH prep
Tx CAndida
FLuconazole
Define Dysmenorrhea
Painful mestruation that affects AODl
TX for dysmenorrhea
NSAIDS
OCPs
Laparoscopy if meds fail
Premenstrual syndrome
Cluster of physical
behavior sx. during clyclic occurance of luteal phase
PMDD
Severe PMS w/ functional impairment
Tx of PMDD
OCP”s
SSRI
GnRH
Refractory breast pain (danazole, bromocriptine)
Sprinolaction and calcium carbonate for bloating
Define Primary amenorrhea
Failure of onset of menarche and secondary sex characteristics by age of 13
or
Failure of onset of menarche (with secondary sex ch.) by age of 16
MC cause of secondary amenorrhea
Pregnancy
Causes of secondary amenorrhea other than pregnancy
Hypothalamic dysfunction Pituitary dysfunction Ovarian d/o (PCOS) Uterine do (ashermans,)
MC pathogen of mastitis
S. aureus
Tx for mastitis
Supportive, warm compress, pump
Dicloxacillin, Nafcillin, cephalosporin
Continue to nurse or use pump
Tx for breast abscess
stop breast feeding from affected side
I&D
Painless, hard, fixed, lump is descriptive of?
breast ca
MC side of breast mass?
UOQ
Breast ca screening should start when?
Annually after age 40
MC cause of PID
N. gonorrhea
Chlamydia
Out pt tx for PID
Doxy and ceftriaxone
In pt tx for PID
Doxy and 2nd gen cephalosporin (cefoxitin)
w/u for ectopic pregnancy
Serial BHCG should doulble q 24-48h, in ectopic serial B HCG fails to double, if inital value <1500 repeat in 2-3d.
Unruptured ectopic tx.
Methotrexate
ruptured ectopic tx
Lap salpingostomy
BHCG markedly elevated indicative of?
Molar pregnancy
US findings in molar pregnancy
Snowstorm or cluster of grapes
When is glucose testing done during preg?
24-28wks
Testing level indicative of GDM and f/u
> 140mg/dL after 1 hr –> do 3hr gtt
Indicates for 3hr GTT
1hr >180 ; 2h >155, and 3h>140
When does RH alloimmunization occur?
When Rh neg mom carries an Rh pos fetus
Tx of Rh incompatability
Preventative: 300ug RhoGAM in Rh neg mom w/ Rh pos dad or unknown at 28wks and then again at 72h after deliver of Rh pos fetus
R/F for PROM
STDs
Smoking
Prior pre term deliver
Multiple gestations
Threatened Ab
CLosed OS, bloody vag discharge, no POC expelled
Inevitable Ab
No POC expelled, progressive cervical dilation, PROM
Incomeplete Ab
Some POC expelled, OS dilated, boggy uterus
Complete Ab
All POC expelled, OS usually closed
Missed Ab
No POC expelled, OS closed, embryo not viable but retained in the uterus
TX for Missed Ab
D&C if 1st trimester
Or Misoprostol
Septic Ab
retained POC becomes infection, some POC retianed, Closed OS w/ CMT
Placenta previa is Painfull or painless?
Painless bleeding
Abruptio placenta is Painful or painless?
Painful bleeding
Tx for placenta previa
tocolytics (stop labor)
Tx for abruptio placenta
Immediate delivery
Define Gestational HTN
HTN without sx, no proteinuria, after 20 wks
Define Preeclampsia
HTN + Proteinuria after 20 wks gestation, NO SEIZURES but HA, Visual sx
MILD BP >140/90
Severe: BP >160/110
HELLP Syndrome is of concern here
HELLP syndrome
Hemolytic anemia, elevated liver enzymes, Low plateltels
Tx for Preeclampsia
Deliver is the only cure
Severe: Mg sulfate, BP meds when BP >180/110 (hydralazine)
Eclampsia definition
Preeclapsia + seizures
Tx of eclampsia
ABCD’s
Mg sulfate for seizure
Deliver of fetus once stabilized
BP meds Hydrazlazine, labetaolol
Chronic HTN during pregnancy
Occurs before 20 wks
Tx of mild chronic HTN during preg.
Monitor and deliver baby at 39-40wk
Tx of severe chronic HTN during preg
(BP>150/100) Methyldopa is tx of choic, Labetalol, nifedipine (AVOID ACI & diuretics)