REPRODUCTIVE Flashcards
Principal advances in the first 10 weeks of fetal development??(6)
Week 1 implantation Week 2 2 layers Bilaminar disc Week 3 3 layers trilaminar disk GASTRULATION Week 4. Heart beating 4 limbs Week 6 ✅ fetal cardiac activity Week 10 genitalia characteristics
What are mesodermal defects VACTEREL?
Vertebral defects
Anal atresia
Cardiac defects
Tracheo-Esophageal fistula
Renal defects
Limb defects (bone and muscle)
Seven most easy teratogenic agents
Amino glycosides CN VIII toxicity
Lithium Ebstein Anomaly
Methimazole Aplasia cutis congenital
Phenytoin Fetal hydantoin syndrome—cleft palate, cardiac defects, phalanx/fingernail hypoplasia
Thalidomide Limb defects 🐬
Valproate neural tube defects
Warfarin Bone , ophthalmologic defects
What’s the effect of maternal diabetes in the fetal development? (3)
Caudal regression syndrome (anal atresia to sirenomelia)
congenital heart defects
neural tube defects
Explain the type of monozygotic twins
13 days embryonic disc MONOCHORIONIC MONOAMNIOTIC SIAMESES
What are the defects of urachus? (3)
Patent urachus
Urachal cyst
Vesicourachal diverticulum
What are the defects of Viteline duct? (2)
Vitelline fistula
Meckel diverticulum
What are aortic arch derivatives (5)?
1st arch is maximal art.
2nd Second = Stapedial and hyoid artery
3rd Common Carotid , internal Carotid
4th ➡️ aortic have arch ⬅️ right subclavian art.
6th pulmonary art. Ductus arteriosus
Explain the first and second arch derivatives
1st Meckel cartilage: Mandible, Malleus, incus, spheno- Mandibular ligament,
Muscles of Mastication and anterior belly of digastric, rtensors
V2. V3 nerves
TREACHER COLLINS SD.
2st Reichert cartilage: Stapes, Styloid process, lesser horn of hyoid, Stylohyoid ligament
Muscles of fascial expression Stapedius, Stylohyoid, platySma, posterior belly of digastric
VII nerve Smile
PHARIGOCUTANEUS FISTULA
Explain the third arch
3rd stylopharyngeus Msc–glossopharyngeal nerve
IX swallow
Explain fourth and sixth arches
4th CN X simply swallow superior laryngeal nerve
pharyngeal constrictors; cricothyroid, levator veli palatini
6th CN X speak recurrent laryngeal nerve
Intrinsic laryngeal muscles
Explain the four pouch derivatives
1 (ear)
2 (tonsils)
3 dorsal (bottom for inferior parathyroids)
3 ventral (to = thymus)
4 (top = superior parathyroids)
Defects in MEN 2A
Adrenal medulla
Parathyroids
Para follicular cells
What hormones are important for male embryologic development?
SRY gene —produces testis- determining factor testes development.
Sertoli cells secretes (MIF) ❎paramesonephric ducts.
Leydig cells secrete androgens ✅mesonephric ducts.
What is the principal embryologic derivative for female internal organs?
Paramesonephric (Müllerian) duct
fallopian tubes, uterus, upper portion of vagina
Müllerian agenesis 1° amenorrhea
What is the principal derivative embryologic male internal male organs?
Mesonephric (Wolffian) duct
Seminal vesicles, Epididymis, Ejaculatory duct, Ductus deferens
In females, remnant Gartner duct.
What are the three uterine anomalies?
Septate uterus
Bicornuate uterus
Uterus didelphys
Explain what last two products make urogenital folds and labioscrotal sweeping in male and female ?
Urogenital folds MALE penile urethra FEMELE Labia minora
Labosicrotal swelling MALE scrotum FEMELE Labia Majora
Associations of hypospadias and epispadias
Hypospadias cryptorchidism inguinal hernia
Epispadia exstrophy of the bladder
Where drains the left tonal vein?
Left renal vein ➡️ IVC
varicocele more common on the left
What ligament is important to ligate in oophorectomy?
Infundibulopelvic ligament (suspensory ligament of the ovary) Contain ovarian ligaments
What is the epithelium in outer surface of ovary?
Simple cuboidal epithelium
Functions of Sertoli cells (6)
Secrete inhibin ❎FSH.
Secrete androgen-binding protein
Produce MIF
Tight junctions
Support and nourish developing spermatozoa
Temperature sensitive
What estrogens are most potent?
Estradiol>estrone>estriol
Explain principal features of tanner stages (5)
I. Childhood (prepubertal)
II. Pubic hair appears (pubarche); breast buds form (thelarche)
III. Pubic hair darkens and becomes curly; penis size/length ; breasts enlarge
IV. Penis width , darker scrotal skin, development of glans; raised areolae
V. Adult; areolae are no longer raised
Definitions about menstruation (6)
Dysmenorrhea PAIN
Oligomenorrhea >35 days
Polymenorrhea 80mL >7days
Menometrorrhagia heavy irregular
Oocyte’s Cycles (3)
Meiosis I is arrested in PROHASE I for years until Ovulation (1° oocytes).
Meiosis II is arrested in METAPHASE II until fertilization (2° oocytes)
Explain the Oocyte development phases (4)
Oogonium Diploid (2N, 2C)
⬇️
1° oocyte Diploid (2N, 4C)
⬇️
2° oocyte Haploid (1N, 2C)
⬇️
Ovum Haploid (1N, 1C)
Time to production of Beta hCG
First 10 weeks
Acting like LH
Eat hCG is augmented and diminished ?(4.4)
hCG is ⬆️in multiple gestations, hydatidiform moles, choriocarcinomas, and Down syndrome
hCG is ⬇️ in ectopic/failing pregnancy, Edward syndrome, and Patau syndrome.
When is premature ovarian failure?
Menopause before age 40
How is the spermatogenesis?(5)
Spermatogonium Diploid(2N, 2C) ⬇️ 1° spermatocyte Diploid (2N, 4C) ⬇️ 2° spermatocyte Haploid (1N, 2C) ⬇️ Spermatid Haploid (1N, 1C) ⬇️ Mature spermatozoon Haploid(1N, 1C)
Potency of the three androgens
DHT>testosterone> androstenedione
How are FSH and LH in klinefelter and Turner syndrome?
⬆️ FSH
⬆️ LH
What’s Female pseudo- hermaphrodite (XX) and Male pseudo- hermaphrodite (XY)
Female pseudo- hermaphrodite (XX) too much androgens
Male pseudo- hermaphrodite (XY) androgen insensitivity syndrome
What’s Kallman syndrome ?
Defective migration of GnRH cells and formation of olfactory bulb; anosmia;
⬇️GnRH, FSH, LH, testosterone.
What signs are related whit hydatidiform mola? (3)
Hyperemesis gravidica
Hyperthyroidism
Preeclampsia
Kariotype and fetal parts in hydatidiform mole
Complete 46 XX , 46 XY
Empty egg+sperm
No parts
SNOWSTORM IN USG
Partial 69 XXX, 69 XXY, 69 XYY
Egg+ 2 sperms
✅Fetal PARTS
What HELLP means?(3)
Hemolysis,
Elevated Liver enzymes
Low Platelets.
Defects in placental implantation deep (3) site (2)
ACRETA attaches myometrium whit out penetrating
INCRETA penetrates into myometrium
PERCRETA penetrates until serosa
PLACENTA PREVIA
Partial
Complete
What’s the incidence of gynecologic tumors?
Endometrial>ovarian>cervical
Histologic features of sarcoma botryoides
Spindle-shaped cells
Desmine ✅
What are the malignant VPH virus and its malignant products?
HPV16
HPV18
E6 (inhibit p53 suppressor gene)
E7( inhibit RB suppressor gene)
What are the sequence of polycystic ovarian syndrome?
Hyperinsulinemia and/or insulin resistance
alter hypothalamic hormonal feedback
⬆️LH:FSH,
⬆️androgens
⬇️rate of follicular maturation
⬆️ unruptured follicles (cysts) + anovulation.
Treatment for polycystic ovarian syndrome (5)
weight reduction OCPs clomiphene citrate ketoconazole spironolactone.
Principal feature of the seven benign ovarian tumors
Serous cystadenoma most common BILATERAL
Mucinous cystadenoma multiloculade large
Endometrioma chocolate cyst complex in USG
Mature cystic teratoma (dermoid cyst)thyroid tissue
Brenner tumor solid like BLADDER
Fibromas MEIGS SYNDROME ovarian fibroma, ascites, hydrothorax. “Pulling” sensation in groin.
Thecoma like Granulosum produce estrogen bleeding post menopause
Principal features of the eight malignant ovarian tumors
Immature teratoma THYROID TISSUE
Granulosa cell tumor abnormal uterine bleeding coffee bean nuclei
Serous cystadenocarcinoma MOST COMMON BILATERAL PSAMMOMA BODIES
Mucinous cystadenocarcinoma. Pseudomixoma peritoneal like apendice
Dysgerminoma adolescents fried egg cells hCG LDH
Choriocarcinoma. ⬆️frequency of bilateral/multiple theca-lutein cysts. ⬆️β-hCG,hemoptysis
Yolk sac (endodermal sinus) most common tumor male infants like gromerulo body ⬆️AFP
Krukenberg tumor primary GI tumor
What are the benign breast tumors ?
Fibroadenoma: 40yrs
What are the different proliferative breast diseases (4)?
Fibrosis
Cystic painful
Sclerosing adenosis
Epithelial hyperplasia
What drugs causes gynecomastia?(5)
Spironolactone Digoxin Cimetidine Alcohol Ketoconazole
What are the general characteristics of malignant breast tumors?(4)
Postmenopausal
Terminal duct lobular unit.
Overexpression of estrogen/progesterone receptors or c-erbB2 (HER-2, an EGF receptor)
Axillary lymph node = metastasis
What’s the the single most important prognostic factor in breast malignant tumor?
Axilary lymph involvement
What makers give poor prognosis in breast tumors ?
triple negative (ER ⊝, PR ⊝, and Her2/Neu ⊝)
Noninvasive breast cancer (3)
Ductal carcinoma in situ (DCIS)
Comedocarcinoma: central necrosis
Paget disease: patches on nipple
What are invasive breast tumors?
Invasive ductal. Rock hard WORST
Invasive lobular INDIAN FILE ⬇️E-cadherin expression
Medullary. Lymphocytic infiltrate good prognosis
Inflammatory Peau d’orange 50%dead
What aré the precursor in situ lesions for squamous cell carcinoma?
Bowen disease
erythroplasia of Queyrat
Bowenoid papulosis
What are the most common extragonadal germ cell tumor?
Sacrococcygeal teratoma in young children
What a the principal features of tsticular germ cell tumors ? (5)
ALL ARE MALIGNANT
Seminoma:“fried egg” placental radio sensible ✅✅ PLAP
Yolk sac (endodermal sinus) tumor:Schiller duval bodies ⬆️AFP