REPRODUCTIVE

Question 1

What 2 antiandrogens are used to prevent hirsutism in PCOS?

Answer 1

Spironolactone and Ketoconazole

Question 2

What is the controversy with DES?

Answer 2

Causes clear cell adenocarcinoma of vagina in females exposed in utero

Question 3

What is the MOA of progestins?

Answer 3

Reduce growth and increase vascularization of the endometrium by binding progesterone receptors

Question 4

What is the MOA of flutamide? What drug is it co-administered with to treat prostatic cancer?

Answer 4

Competitive antagonist for testosterone at the androgen receptor; administered with CONTINUOUS leuprolide

Question 4

What are the 3 estrogen drugs?

Answer 4

Ethinyl estradiol, mestranol, and DES = Diethylstilbestrol

Question 4

Which SERM increases the risk for cervical cancer? Which has no effect?

Answer 4

Tamoxifen, Raloxifene

Question 4

What is the MOA and use of Mifepristone? What is it given with?

Answer 4

A competitive inhibitor of progestins at the endometrium? Used to terminate pregnancy. Given with misoprostol (PGE1)

Question 5

Which SERM is used to induce ovulation?

Answer 5

Clomiphene

Question 5

Which SERM is used for breast cancer and in preventing recurrences of Estrogen-Receptor positive breast cancer?

Answer 5

Tamoxifen

Question 5

This drug inhibits the alpha 1 a, d receptor

Answer 5

Tamsulosin for BPH

Question 6

In whom are OCP’s contraindicated?

Answer 6

Smokers over 35 and ppl with Hx of thromboembolism

Question 7

What is another name for RU-486?

Answer 7

Mifepristone–competitive inhibitor of progestins

Question 9

This is a beta-2 agonist that relaxes the uterus and prevents premature contractions

Answer 9

Terbutaline

Question 10

Which SERM is used mostly for osteoporosis?

Answer 10

Raloxifene

Question 10

What is the use of tamsulosin? Receptor?

Answer 10

Treats BPH by inhibiting smooth muscle contraction? alpha 1a,d

Question 12

Which OCP’s cause thickening of the cervical mucus making sperm motility more difficult?

Answer 12

progestins

Question 13

What is the MOA and use of terbutaline?

Answer 13

Beta-2 agonist that relaxes uterus and prevents premature contractions

Question 15

MOA of testosterone and methyltestosterone

Answer 15

Agonist at androgen receptors

Question 15

What is testosterone and methyltestosterone used for clinically?

Answer 15

Hypogonadism and forming secondary sex characteristics

Question 15

AE of PDE-5 inhibitors (4)

Answer 15

Headache, flushing, dyspepsia (heart burn), and risk of hypotension with nitrates

Question 16

How are ketoconazole and spironolactone anti-androgenics? What AE do they share?

Answer 16

Ketoconazole inhibits 17, 20 desmolase so inhibits steroid synthesis, Spironolactone prevents steroid binding? Both cause gynecomastia and amenorrhea

Question 17

What kind of drug are anastrozole and exemestane?

Answer 17

Aromatase inhibitors

Question 18

4 uses of leuprolide

Answer 18

Infertility = pulsatile, prostate CA = continuous and with flutamide, Uterine Fibroids (continuous) and Precocious puberty (continuous)

Question 20

Which drugs inhibit phosphodiesterase 5? Phosphodiesterase 3?

Answer 20

Sildenafil, vardenafil etc.; Cilostazol and Dipyridamole

Question 21

MOA of finasteride? Uses?

Answer 21

5-alpha reductase inhibitor (no DHT formed)? Tx of BPH and Male Pattern Baldness

Question 22

How do synthetic estrogens and progestins act as oral contraceptives?

Answer 22

They inhibit LH and FSH via negative feedback and therefore prevent ovulation; also, progestins thicken cervical mucus which makes it difficult for sperm to get through

Question 23

Name 2 aromatase inhibitors

Answer 23

Anastrozole and Exemestane

Question 24

What are the 2 contraindications of estrogen therapy in women?

Answer 24

Hx of DVT's or ER (estrogen receptor) positive breast CA

Question 25

What antiandrogen is used to treat prostate cancer?

Answer 25

flutamide

Question 27

This GnRH analog is an agonist when used pulsatile and antagonist when continuous

Answer 27

Leuprolide

Question 27

In the context of the reproductive system, what are spironolactone and ketoconazole used for?

Answer 27

Preventing hirsuitism in polycystic ovarian syndrome

Question 28

Which drug can be used to shrink uterine fibroids?

Answer 28

Continuous leuprolide (GnRH analog)

Question 30

What kind of drug is danozol?

Answer 30

Synthetic androgen acting as a partial agonist at androgen receptors

Question 31

This is a synthetic partial agonist androgen used in endometriosus and hereditary angioedema

Answer 31

danozol

Question 33

Which repro system drugs can cause blue-green vision?

Answer 33

PDE-5 inhibitors-- sildenafil and vardenafil

Question 35

What kind of drug is mestranol?

Answer 35

An estrogen

Question 36

What 2 drugs are used in conjunction for prostate cancer?

Answer 36

Leuprolide (GnRH analog used CONTINUOUSLY) and Flutamide (nonsteroidal competitive inhibitor of androgens at testosterone receptor)

Question 37

When are estrogens used in men?

Answer 37

Androgen dependent prostate CA

Question 38

What are the lipid effects of testosterone?

Answer 38

Increase LDL and decrease HDL

Question 40

Which antiandrogenic drug inhibits 17, 20 desmolase?

Answer 40

Ketoconazole

Question 41

List the 4 antiandrogens

Answer 41

Finasteride, Flutamide, Spironolactone, and Ketoconazole

Question 42

What is the MOA of clomiphene to induce ovulation?

Answer 42

Partial agonist of estrogen receptors in hypothalamus causes release of LH and FSH (induces LH surge)