IMMUNO AND ENVIRONMENTAL TOXINS Flashcards
Which drug increases the toxic effects of azathioprine and 6-mercaptopurine?
Allpurinol, both are metabolized by xanthine oxidase
What is the MOA of sirolimus?
inhibits mTOR which inhibits T cell proliferation in response to IL-2
What would arsenic cause in the liver?
Angiosarcoma
Which AE does cyclosporine have that tacrolimus does not have?
Gingival hyperplasia and Hirsutism
What drug binds to cyclophilin forming a complex that then inhibits calcineurin and blocks differentiation and activation of T cells by preventing IL-2 and IL-2R production?
Cyclosporine
What can naphthalene cause?
Transitional cell carcinoma
Which immunosuppressive drug inhibits mTOR?
Sirolimus (rapamycin)
What is the difference between tacrolimus and cyclosporine?
Both ultimately block calcineurin; but cyclosporin does so by forming a complex with cyclophilin and tacrolimus does so by forming a complex with FK-binding protein
What effect might aflatoxins have on the body?
Hepatocellular carcinoma
What would arsenic cause on the skin?
SCC
What drug binds to FK-binding protein and inhibits calcineurin and secretion of IL-2?
Tacrolimus
What 2 environmental toxins can cause angiosarcoma of the liver?
Vinyl chloride and Arsenic
What is muromonab-CD3 used for?
Prevent acute transplant rejections
What drug is also known as rapamycin?
sirolimus
Which monoclonal antibody binds to CD3 to prevent T-Cell signal transduction?
Muromonab-CD3
