IMMUNO AND ENVIRONMENTAL TOXINS Flashcards
Which drug increases the toxic effects of azathioprine and 6-mercaptopurine?
Allpurinol, both are metabolized by xanthine oxidase
What is the MOA of sirolimus?
inhibits mTOR which inhibits T cell proliferation in response to IL-2
What would arsenic cause in the liver?
Angiosarcoma
Which AE does cyclosporine have that tacrolimus does not have?
Gingival hyperplasia and Hirsutism
What drug binds to cyclophilin forming a complex that then inhibits calcineurin and blocks differentiation and activation of T cells by preventing IL-2 and IL-2R production?
Cyclosporine
What can naphthalene cause?
Transitional cell carcinoma
Which immunosuppressive drug inhibits mTOR?
Sirolimus (rapamycin)
What is the difference between tacrolimus and cyclosporine?
Both ultimately block calcineurin; but cyclosporin does so by forming a complex with cyclophilin and tacrolimus does so by forming a complex with FK-binding protein
What effect might aflatoxins have on the body?
Hepatocellular carcinoma
What would arsenic cause on the skin?
SCC
What drug binds to FK-binding protein and inhibits calcineurin and secretion of IL-2?
Tacrolimus
What 2 environmental toxins can cause angiosarcoma of the liver?
Vinyl chloride and Arsenic
What is muromonab-CD3 used for?
Prevent acute transplant rejections
What drug is also known as rapamycin?
sirolimus
Which monoclonal antibody binds to CD3 to prevent T-Cell signal transduction?
Muromonab-CD3
What effect might vinyl chloride have on the body?
Liver angiosarcoma
What effect do nitrosamines have on the body?
Gastric Cancer
What is asbestos most likely to cause?
Bronchogenic carcinoma > mesothelioma
What effect might carbon tetrachloride have on the body?
Centrilobular necrosis and fatty change
Which antimetabolite is a precursor of 6-mercaptopurine?
Azathioprine
Which immunsuppressive drug has gingival hyperplasia as an AE? What anticonvulsant?
Cyclosporine; Phenytoin
