Repro drugs

Question 1

Leuprolide mechanism

Answer 1

GnRH analog

Question 2

use: leuprolide

Answer 2

1. infertility (give pulsatile)

2. prostate cancer, prostate cancer, uterine fibroids, precocious puberty (continuous)

Question 3

tox leuprolide

Answer 3

antiandrogen, N/V

Question 4

testosterone use:

Answer 4

hypogonadism

burn victims

Question 5

effect of testosterone on LDL and HDL

Answer 5

increase LDL

Decrease HDL

Question 6

finasteride mech

Answer 6

5a reductase inhibitor

Question 7

use of finasteride

Answer 7

BPH

hair growth

Question 8

flutamide mechanism

Answer 8

competitive inhibitor of androgens at testosterone receptor

Question 9

use: flutamide

Answer 9

prostate carcinoma

Question 10

ketoconazole mechanism

Answer 10

inhibits steroid synthesis thru desmolase

Question 11

spironolactone mech

Answer 11

blocks testosterone binding

Question 12

use: ketoconazole and spironolactone

Answer 12

Hirsutism in PCOS

Question 13

DES and mestranol

Answer 13

estrogens

Question 14

mech clomiphene

Answer 14

estrogen partial agonist blocking feedback inhibition. Increase in LH/FSH=ovulation

Question 15

tox clomiphene

Answer 15

hot flashes, multiple pregnancies
ovarian enlargement
visual disturbances

Question 16

tamoxifen mechanism

Answer 16

estrogen antagonist on breast tissue

Question 17

use: tamoxifen

Answer 17

ER positive breast cancers

Question 18

raloxifene mechanism

Answer 18

1. bone estrogen agonist

2. estrogen antagonist elsewhere

Question 19

indication for raloxifene

Answer 19

osteoporosis

Question 20

tox HRT

Answer 20

endometrial cancer possibly CV risk

Question 21

what do we add to estrogen in HRT to reduce risk of endometrial cancer

Answer 21

progesterone

Question 22

anastrozole/exemestane mechanism

Answer 22

aromatase inhibitors in postmenopausal women with breast cancer

Question 23

use: progestins

Answer 23

endometrial cancer

abnormal uterine bleeding

Question 24

mifepristone mechanism

Answer 24

competitive inhibitor of progestins

Question 25

use: Mifepristone

Answer 25

termination of pregnancy with misoprostol (PGE1)

Question 26

mechanism OCP

Answer 26

Inhibition of LH/FSH and no estrogen surge =no LH surge THickening of cervical mucus

Question 27

terbutaline mechanism

Answer 27

B2 agonist | --relaxes uterus

Question 28

use: terbutaline

Answer 28

reduces premature uterine contractions

Question 29

tamsulosin mechanism

Answer 29

a1 antagonist selective for prostate receptors a1AD

Question 30

use: tamsulosin

Answer 30

BPH

Question 31

sildenafil mechanism

Answer 31

inhibits phosphodiesterase 5, increasing cGMP | --relaxing smooth muscle

Question 32

tox of sildenafil

Answer 32

headache, hot, heartburn | Impaired blue/green vision

Question 33

sildenafil contraindicated in

Answer 33

pts taking nitrates | --LIFE THREATENING HYPOTENSION

Question 34

Danazol mechanism

Answer 34

Synthetic androgen | --Partial agonist at androgen receptors

Question 35

Use danazol

Answer 35

endometriosis and hereditary angioedema

Question 36

tox of danazol

Answer 36

``` weight gain edema acne masculinization HEPATOTOX low HDL ```