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Repro drugs Flashcards

1
Q

Leuprolide mechanism

A

GnRH analog

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2
Q

use: leuprolide

A
  1. infertility (give pulsatile)

2. prostate cancer, prostate cancer, uterine fibroids, precocious puberty (continuous)

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3
Q

tox leuprolide

A

antiandrogen, N/V

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4
Q

testosterone use:

A

hypogonadism

burn victims

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5
Q

effect of testosterone on LDL and HDL

A

increase LDL

Decrease HDL

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6
Q

finasteride mech

A

5a reductase inhibitor

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7
Q

use of finasteride

A

BPH

hair growth

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8
Q

flutamide mechanism

A

competitive inhibitor of androgens at testosterone receptor

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9
Q

use: flutamide

A

prostate carcinoma

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10
Q

ketoconazole mechanism

A

inhibits steroid synthesis thru desmolase

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11
Q

spironolactone mech

A

blocks testosterone binding

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12
Q

use: ketoconazole and spironolactone

A

Hirsutism in PCOS

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13
Q

DES and mestranol

A

estrogens

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14
Q

mech clomiphene

A

estrogen partial agonist blocking feedback inhibition. Increase in LH/FSH=ovulation

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15
Q

tox clomiphene

A

hot flashes, multiple pregnancies
ovarian enlargement
visual disturbances

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16
Q

tamoxifen mechanism

A

estrogen antagonist on breast tissue

17
Q

use: tamoxifen

A

ER positive breast cancers

18
Q

raloxifene mechanism

A
  1. bone estrogen agonist

2. estrogen antagonist elsewhere

19
Q

indication for raloxifene

A

osteoporosis

20
Q

tox HRT

A

endometrial cancer possibly CV risk

21
Q

what do we add to estrogen in HRT to reduce risk of endometrial cancer

A

progesterone

22
Q

anastrozole/exemestane mechanism

A

aromatase inhibitors in postmenopausal women with breast cancer

23
Q

use: progestins

A

endometrial cancer

abnormal uterine bleeding

24
Q

mifepristone mechanism

A

competitive inhibitor of progestins

25
Q

use: Mifepristone

A

termination of pregnancy with misoprostol (PGE1)

26
Q

mechanism OCP

A

Inhibition of LH/FSH and no estrogen surge
=no LH surge
THickening of cervical mucus

27
Q

terbutaline mechanism

A

B2 agonist

–relaxes uterus

28
Q

use: terbutaline

A

reduces premature uterine contractions

29
Q

tamsulosin mechanism

A

a1 antagonist selective for prostate receptors a1AD

30
Q

use: tamsulosin

31
Q

sildenafil mechanism

A

inhibits phosphodiesterase 5, increasing cGMP

–relaxing smooth muscle

32
Q

tox of sildenafil

A

headache, hot, heartburn

Impaired blue/green vision

33
Q

sildenafil contraindicated in

A

pts taking nitrates

–LIFE THREATENING HYPOTENSION

34
Q

Danazol mechanism

A

Synthetic androgen

–Partial agonist at androgen receptors

35
Q

Use danazol

A

endometriosis and hereditary angioedema

36
Q

tox of danazol

A 
weight gain
edema
acne
masculinization
HEPATOTOX
low HDL

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