Repro

Question 1

ACE teratogen effect?

Answer 1

renal damage

Question 2

alkylating agent teratogen effect?

Answer 2

absent digits, multiple anomalies

Question 3

aminoglycosides teratogen effect?

Answer 3

CN 8 tox “a mean guy” hit baby in the ear

Question 4

carbamazepine teratogen effect?

Answer 4

NEURAL TUBE DEFECT, craniofacial, fingernail hypoplasia, developmental delay, IUGR

Question 5

DES teratogen effect?

Answer 5

vaginal clear cell adenocarcinoma, congenital Mullerian anomalies

Question 6

lithium teratogen effect?

Answer 6

Ebstein anomaly (atrialized right ventricle)

Question 7

Methimazole teratogen effect?

Answer 7

aplasia cutis congenita

Question 8

phenytoin teratogen effect?

Answer 8

CARDIAC DEFECTS, fetal hydantoin syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails & distal phalanges, IUGR, intellectual disability

Question 9

tetracyclin teratogen effect?

Answer 9

discolored “teethracyclines”

Question 10

thalidomide teratogen effect?

Answer 10

limb defects (phocomelia, micromelia -flippers)

Question 11

Valproate teratogen effect?

Answer 11

inhibition of folate absorption ->neural tube probs “valproATE inhibits folATE”

Question 12

Warfarin teratogen effect?

Answer 12

bone deformities, fetal hemorrhage, abortion, ophthalmologic abnormalities

Question 13

cocaine teratogen effect?

Answer 13

abnormal growth & addiction. placental abruption (due to vasoconstriction, same as meth)

Question 14

smoking teratogen effect?

Answer 14

low birth weight, preterm labor, placental problems, IUGR, ADHD

Question 15

iodine teratogen effect?

Answer 15

CRETINISM (hypothyroid) or congenital goiter

Question 16

maternal diabetes teratogen effect?

Answer 16

CAUDAL REGRESSION SYNDROME (ANAL ATRESIA TO SIRENOMELIA), CONGENITAL HEART DEFECTS, neural tube defects

Question 17

Vitamin A excess teratogen effect?

Answer 17

spontaneous abortion, cleft palate, cardiac probs

Question 18

x-ray teratogen effect?

Answer 18

microcephaly & retardation

Question 19

Heroin teratogen effect?

Answer 19

! Intracerebral hemorrhage, acoustic startle, hypoglycemia (give tapering opium)

Question 20

ethanol teratogen effect?

Answer 20

Fetal alcohol syndrome

[small face & holoprosencephaly, retard, heart prob, limb dislocation]