Endocrine Flashcards
Addison’s deficiency of?
aldosterone, cortisol. All 3 CORTICAL divisions of adrenal gland are affected.
[distinguish from 2 degree adrenal insufficiency (down ACTH), which has no skin hyperpigmentation and no hyperkalemia]
Aldosterone up does?
blood K+ down, blood H+ down, blood pressure up
Cortisol up does?
-
ACTH up does?
skin hyperpigmentation, stim cortisol and a bit aldosterone
Down serum Mg does what to PTH secretion?
Up PTH secretion
WAY down serum Mg does what to PTH secretion?
Down PTH secretion (since Ca and Mg compete for kidney reabsorption)
cAMP pathway is for which hormones?
FLAT ChAMP
- FSH
- LH
- ACTH
- TSH
- CRH
- hCG
- ADH (V2 receptor)
- MSH
- PTH
- calcitonin
- GHRH
- glucagon
cGMP pathway is for which hormones?
Think vasodilators:
- ANP
- NO (EDRF)
IP3 pathway is for which hormones?
GOAT HAG
- GnRH
- Oxytocin
- ADH (V1 receptor)
- TRH
- Histamine
- Angiotensin II
- Gastrin
Steroid receptor pathway is for which hormones?
VETTT CAP
- Vit D
- Estrogen
- Testosterone
- T3, T4
- Cortisol
- Aldosterone
- Progesterone
Intrinsic tyrosine kinase pathway is for which hormones?
MAP kinase pathway - think growth factors
- Insulin
- IGF-1
- FGF
- PDGF
- EGF
Receptor-associated tyrosine kinase pathway is for which hormones?
JAK/STAT pathway. Think acidophils and cytokines. “PIG”
- Prolactin
- Immunomodulators (eg cytokines IL-2, 6,8, IFN)
- GH
GLUT-4 function? Insulin-dependent or not?
adipose, muscle.
Dependent.
GLUT-1 function? Insulin-dependent or not?
RBC, brain, cornea
not
GLUT-5 function? Insulin-dependent or not?
fructose intake (spermatocytes, GI) not
