Heme

Question 1

Aspirin’s action on thrombogenesis?

Answer 1

Inhibit COX-> Down TXA2 (thromboxane) synthesis

Question 2

Ticlopidine action on thrombogenesis?

Answer 2

inhibit ADP-induced expression of Gp2b

Question 3

Clopidogrel action on thrombogenesis?

Answer 3

inhibit ADP-induced expression of Gp2b

Question 4

Abciximab action on thrombogenesis?

Answer 4

inhibit Gp2b directly

Question 5

Ristocetin action on thrombogenesis?

Answer 5

Activate vWF to bind to Gp1b.

[used for dx of Von Willebrand dz, wherein normal platelet aggregation is defective]

Question 6

Argatroban mech?

Answer 6

Direct thrombin inhibit

Question 7

Bivalirudin mech?

Answer 7

Direct thrombin inhibit

Question 8

Apixaban mech?

Answer 8

Direct Xa inhibit

Question 9

Rivaroxaban mech?

Answer 9

Direct Xa inhibit

Question 10

Thrombolytic drug ending?

Answer 10

“Plase” (alteplase (tPA), reteplase (rPA), tenecteplase (TNK-tPA)

Question 11

Clopidogrel mech?

Answer 11

ADP receptor inhibitor

Question 12

Ticlopidine mech?

Answer 12

ADP receptor inhibitor

Question 13

Prasugrel mech?

Answer 13

ADP receptor inhibitor

Question 14

Ticagrelor mech?

Answer 14

ADP receptor inhibitor

Question 15

Cilostazol mech?

Answer 15

Phosphodiesterase III inhibit (up cAMP in platelets, also vasodilates)

Question 16

Dipyridamole mech?

Answer 16

Phosphodiesterase III inhibit (up cAMP in platelets, also vasodilates)

Question 17

Abciximab mech?

Answer 17

Bind GPIIb (made from monoclonal Fab fragments)

Question 18

Eptifibatide mech?

Answer 18

Bind GPIIb

Question 19

Tirofiban mech?

Answer 19

Bind GPIIb