Renal4 Flashcards by Filip Garrett | Brainscape

Q

Kidney Endocrine functions:

- Erythropoietin

A

Interstitial cells in peritubular capillary bed

- In response to Hypoxia

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Q

Kidney Endocrine functions:

- 1,25-(OH)2 Vitamin D

A

-Proximal tubule cells convert 25-OH vit. D to 1,25-(OH)2 vit. D (ACTIVE form)

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Q

Kidney Endocrine functions:

- Renin

A

Secreted by JG cells

Low renal arterial pressure
Increased renal sympathetic discharge (ß1 effect)

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Q

Kidney Endocrine functions:

- Prostaglandins

A

Paracrine secretion
VasoDILATES the AFFERENT arterioles
INcrease GFR

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Q

How can NSAIDs cause Acute renal failure?

A

Inhibit prostaglandins

- Afferent arterioles cant vasodilate to maintain GFR

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Q

What enzyme is involved in conversion of 25-OH vit. D to 1,25-(OH)2 vit. D?

A

1a-hydroxylase

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Q

What activates 1a-hydroxylase?

A

PTH

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