Renal13 Flashcards
What is the most common renal malignancy?
Renal cell carcinoma
Renal Cell Carcinoma:
-Pathology
- Originates in Proximal Tubule
- Polygonal celar cells
- Filled with lipids and carbs
Renal Cell Carcinoma:
-Risk factors
- Men 50-70
- Smoking
- Obesity
Renal Cell Carcinoma:
-Signs/Symptoms
- Hematuria
- Palpable mass
- 2˚ polycythemia
- Flank pain
- Fever
- Weight loss
Renal Cell Carcinoma:
-Invasion and Metastasis
- Invades Renal V. then IVC
- Spreads hematogenously
- Mets to Lung & Bone
Renal Cell Carcinoma:
-Genetics
- Gene deletion on Chr13
- Sporadic or
- Inherited (von Hippel-Lindau syndrome)
Renal Cell Carcinoma:
-Paraneoplastic syndromes
- Ectopic EPO
- ACTH
- PTHrP
Renal Cell Carcinoma:
-“silent cancer”
- In retroperitoneum
- Presents as a metastatic neolasm
What is the treatment for Renal Cell Carcinoma?
Resection if localized disease
*RESISTANT to conventional chemotherapy and radiation therapy
T/F - Renal cell carcinoma is resistent to conventional chemotherapy and radiation therapy.
True
What is the most common renal malignancy of early childhood (2-4 y/o)?
Wilms’ tumor (Nephroblastoma)
Wilms’ tumor (nephroblastoma):
-Genetics
-Deletion of tumor suppressor gene WT1 on Chr11
Wilms’ tumor (nephroblastoma):
-Pathology
- Embryonic glomerular structures
- Neoplastic embryonic renal cells of the metanephros
Wilms’ tumor (nephroblastoma):
-Presentation
- Huge, palpabel flank mass
- (+/-) Hematuria
What two syndromes are associated with Wilms’ tumor?
- Beckwith-Wiedmann syndrome
- WAGR complex
