Renal Tumors- MJ Flashcards
Which renal carcinoma?
- Most common in men
- Median age of dx= 64y/o (6th-8th decades)
- Strong association w/ smoking
Renal Cell Carcinoma
Which is the MC primary renal malignancy?
Renal Cell Carcinoma
What is the biggest risk factor for Renal Cell Carcinoma?
SMOKING
(will be on exam)
The following are risk factors for which renal tumor?
- Smoking
- HTN
- obesity
- chronic dialysis
- toxic exposure (abestosis)
- Heavy ASA, NSAIDs or Acetaminophen use
- Genetics
Renal Cell Carcinoma
What is the most common type of renal cell carcinoma?
Clear Cell (75-85%)
Which type of renal cell carcinoma?
- Depletion of Chromosome 3p
- Proximal tubule
- usually solid
Clear Cell Renal Cell Carcinoma (the MC)
Which type of Renal Cell Carcinoma?
- Less common (10-15%)
- Proximal Tubule
- Type 1- usually stage I or II at dx, good prognosis
- Type 2- aggressive, usually stage III or IV at dx
Papillary (chromophilic) Renal Cell Carcinoma
What is the classic presentation of Renal Cell Carcinoma (3 things)
- Hematuria (MC)
- Abdominal Mass
- Flank pain
The following are the clinical presentation of what?
- Hematuria
- abdominal mass
- flank pain
- Weight loss
- L-sided scrotal varicocele
(bolded= MC)
Renal Cell Carcinoma
What are the 5 MC site of metastasis for Renal Cell Carcinoma?
- Lungs
- Lymph Nodes
- Bone
- Liver
- Brain
The following paraneoplastic syndromes are associated with which renal cancer?
- Anemia
- Hepatic dysfunction
- Fever
- Hypercalcemia
- Cachexia
- Erythrocytosis
- Secondary amyloidosis
- Thrombocytosis
- Polymyalgia rheumatica
Renal Cell Carcinoma
What is the initial diagnostic test for Renal Cell Carcinoma?
Abdominal CT with/without contras
If you have a patient that you think might have Renal Cell Carcinoma and the initial CT is non-diagnostic (or the patient has a contraindication to contrast), what would be your next choice of test?
MRI
What is the definitive diagnostic test for Renal Cell Carinoma?
Tissue Biopsy (Nephrectomy or partial nephrectomy)