Renal QBank

Question 1

Bilateral Angiomyolipoma cause

Answer 1

Tuberous sclerosis

Question 2

Transplant Tx

Answer 2

Cyclosporine or Tacrolimus inhibit (calcineurin -> IL-2 -> T lymphocytes)

Question 3

Bcl-2

Answer 3

Apoptosis inhibitor

-Overexpressed in follicular cell lymphoma (t(14;18) translocation)

Question 4

Neurofibromin

Answer 4

Tumor suppressor protein (NF-1 gene)

-suppresses Ras

Question 5

NSAIDs on kidney

Answer 5

Afferent constriction

Question 6

ACE-I on kidney

Answer 6

Efferent constriction

Question 7

Angiotensin effect

Answer 7

• Systemic vasoconstriction
• Efferent glomerular arteriole constriction (decrease GFR)
• Enhanced adrenal cortical aldosterol secretion

Question 8

Vasopressin MOA

Answer 8

V-R mediated increase inner medullary collecting duct permeability to water and urea (more collection)

Question 9

Aspirin toxicity

Answer 9

First - Respiratory alkalosis (medulla stimulation -> hyperventilation)
Hours later - Metabolic acidosis

Question 10

Amphotericin B effect on kidney

Answer 10

acute tubular necrosis

• Hypokalemia
• Hypomagnesemia

Question 11

Renal oncocytoma

Answer 11

Rare collecting duct cancer

-Numerous mitochondria

Question 12

Transitional cell carcinoma

Answer 12

Renal pelvis

-Papillary tumors (w/stalk)

Question 13

Renal clear cell carcinoma

Answer 13

Proximal renal tubules

• Polygonal cells with abundant cytoplasm
• Golden yellow on gross examination