Antidotes

Question 1

Acetaminophen

Answer 1

N-acetylcysteine (replenish glutathione)

Question 2

Salicylates

Answer 2

• NaHCO3 (alkalinize urine)

- Dialysis

Question 3

Amphetamines

Answer 3

NH4Cl (acidify urine)

Question 4

Organophosphates (Ach-ase inhibitors)

Answer 4

Atropine, pralidoxime

Question 5

Antimuscarinic, Anticholinergic agents

Answer 5

• Physostigmine salicylate

- Control hyperthermia

Question 6

B-Blockers

Answer 6

Glucagon

Question 7

Digitalis

Answer 7

KLAM

• Normalize K
• Lidocaine
• Anti-dig Fab fragments
• Mg

Question 8

Iron

Answer 8

• Deferoxamine

- Deferasirox

Question 9

Lead

Answer 9

• CaEDTA
• Dimercaprol
• Succimer
• Penicillamine

Question 10

Mercury, arsenic, gold

Answer 10

• Dimercaprol

- Succimer

Question 11

Copper, arsenic, gold

Answer 11

Penicillamine

Question 12

Cyanide

Answer 12

• Amyl Nitrite

- Hydroxocobalamin

Question 13

Methemeglobin

Answer 13

• Methylene blue

- Vitamin C

Question 14

Carbon Monoxide

Answer 14

100% O2

Question 15

Methanol, ethylene glycol (antifreeze)

Answer 15

-Fomepizole > dialysis

Question 16

Opioids

Answer 16

Naloxone/Naltrexone

Question 17

Benzodiazepines

Answer 17

Flumazenil

Question 18

TCAs

Answer 18

NaHCO3 (plasma alkalinization)

Question 19

Heparin

Answer 19

Protamine sulfate

Question 20

Warfarin

Answer 20

Vit. K

IV frozen plasma if severe

Question 21

tPA, streptokinase, urokinase

Answer 21

Aminocaproic acid

Question 22

Theophylline

Answer 22

B-Blocker

Question 23

Aspirin toxicity course (not antidote)

Answer 23

First - Respiratory alkalosis (medulla stimulation -> hyperventilation)
Hours later - Metabolic acidosis (inhibit CAC, increase burning, build up lactic acid)

Question 24

Aspirin toxicity course (not antidote)

Answer 24

First - Respiratory alkalosis (medulla stimulation -> hyperventilation)
Hours later - Metabolic acidosis (inhibit CAC, increase burning, build up lactic acid)