Renal Embryology Flashcards

1
Q

Origin and Location fo Intermediate Mesoderm

A

1) Origin: Epiblast Layer -> Mesenchymal Cells
2) Location: Trunk; Lateral to Somites

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2
Q

What forms the Nephrogenic Cord?

A

Urogenital Ridge

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3
Q

What forms the Urogenital ridge?

A

Intermediate Mesoderm

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4
Q

What does the Nephrogenic Cord Form?

A

1) Pronephros
2) Mesnephros
3) Metanephros

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5
Q

Pronephros develps during what week? Where is it located?

A

1) 4th
2) Cervical region

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6
Q

When does the Pronephros Degenerate

A

24th - 25th day

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7
Q

Pronephros Includes ___

A

Pronephric Ducts

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8
Q

The Pronephric Ducts are formed from ____ and open into ___.

A

Intermediate Mesoderm

Cloaca

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9
Q

Mesonephros Develops ____ wk. Where is it located?

A

4th wk

Caudal to Pronephros

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10
Q

What does the mesonephros include?

A

1) Mesonephric Ducts
2) Mesonephric Tubules

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11
Q

What induces the surrounding mesoderm to form Mesonephric Tubules

A

Mesonephric Ducts

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12
Q

What does Mesonephric Tubules Form

A

Renal Corpuscles

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13
Q

By 6-10 wks mesonephric tubules will form and produce small amounts of ___

A

Urine

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14
Q

Medial end of mesonephric tubules will form ______

A

Glomerular Capsule

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15
Q

Mesonephric tubules degenerate by ___

A

12 wk

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16
Q

In males MEsonephric Tubules will not degenerate and will form ____

A

Efferenet Ductles

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17
Q

Metanephros begins to form ___ wk

A

5th

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18
Q

What induces Metanephros development

A

Mesonephric Duct

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19
Q

What makes up the metanephros

A

Uteric Bud

Metanephric Blastma

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20
Q

What derives the uteric bud

A

out growth of Mesonephric Duct

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21
Q

What is the metanephric blastema developed from>

A

Nephrogenic Cord

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22
Q

Functional Definitive Kidney forms by wks __ - __-

A

9th-10th

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23
Q

Functional Definitive Kidney will have ___ portion and ____ portion

A

Excretory

Collecting

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24
Q

Origin of Mesonephric Ducts

A

Persistent Pronepric Ducts (intermediate mesoderm0

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25
Ureteric Bud will develp the ___ portion
Collecting
26
What does the Ureteric Bud Form
1) Ureter via stalk of Ureteris Bud 2) Renal Pelvis 3) Major and Minor Calyces 4) Collecting Ducts
27
Metanephric Blastema forms the ___ portion
Excertory Protion
28
What does the Metanephric Blastema Form?
1) Bowman's Capsule 2) Proximal Convoluted tubule 3) Loop of Henle 4) Distal Convoluted Tubule
29
Describe Nephron Development
1) Cranial poriton of ureteric bud forms collecting tubules 2) Collecting Tubules Branch --\> Arched Collecting tubules 3) Arched Collecting Tubules induce Metanephrogenic Blastema to form Metanephric vesicles 4) Metanephric vesicle enlogates to for metanephric tubule 5) Proximal Metanephric Tubule form Glomerular Capsule 6) Distal Metanephric Tubule forms PCT DCT amd Nephron Loop 7) DCT connects to arched collecting tubule
30
Ventral Cloaca is the ___ hindgut
distal
31
Ventral Cloaca splits into two things. What are they?
Urogenital Sinus Anorectal Canal
32
Urogenital Sinus Becomes forms the ____ and \_\_\_
Bladder Urethral Development
33
Urogenital Sinus is split up into 3 parts. What are they?
1) Vesical Part 2) Pelvic Part 3) Phallic Part
34
Vesical Part of the Urogenital Sinus forms:
Majority of Urinary Bladder
35
Pelvic Part of Urogenital Sinus forms ___ and ____ and \_\_\_\_
Neck of Bladder Prostatic Urethra (m) Urethra (f)
36
Phallic Part forms what?
Spongy Urethra (m) and Lining of Vaginal Vestibule
37
Bladder Epithelium is derived from
Endoderm (Urogenital Sinus)
38
Submucosa and Muscularis of Bladder is derived from \_\_\_
Splanchnic Mesoderm
39
Trigone of Bladder is made from
Intermediate Mesoderm (Mesonephric Ducts)
40
Describe Epispadias
Dorsal Urethral Opening (Dorsum of genital tubercle) Rather than Ventral
41
\_\_\_\_ is often associated with Epispadias
Extrophy of Bladder
42
When does Extrophy of the Bladder usually occur
4th week
43
What Causes Extrophy of Bladder
Ventral Wall Closure
44
What derives the fetal cortex (Suprarenal Glands) and the fetal fortical cells.
Celomic Epithelium with in surrounding mesoderm
45
What does the Fetal Cortex secrete that is important for maintaining Pregancy
DHEA
46
In the Placenta what does the DHEA get converted into?
Estradiol
47
Definitive Cortical Cells of derive adult structures of Suprarenal Glands. What do form.
Zona Glomerulosa Zona Fasciculata Zona Reticularis
48
What are the two types of Renal Agenesis.
1) Unilateral 2) Bilateral
49
\_\_\_\_ renal agenesis is seen in infants with 1 umbilical a.
Unilateral
50
Is Unilateral Renal Agenesis Symptomatic?
NO
51
Bilateral Renal Agenesis results in \_\_\_\_
Oligohydraminos which leads to Pulmonary Hypoplasia
52
What causes Ureter Duplications
Abnormal Divisions of Ureteric Bud
53
What are the two types of Ureter Duplications
Incomplete Complete
54
Describe Incomplete Ureter Duplication
Divided Kidney and Bifed Ureter
55
Describe Complete Ureter Duplication
Double kidney and bifed ureter or seperate ureters
56
Cause of Horseshoe Kidneys
Fusion of inf. poles to form isthmus
57
\_\_\_ prevents proper superior positioning of kidneys in Horseshoe kidney
IMA
58
Polycystic Kidney Disease (ARPKD) is ___ recessive and associated with \_\_\_\_
1) Autosomal recessive 2) Pulmonary Hypoplasia
59
What is the gene mutation in ARPKD (Polycystic Kidney Disease)
PKHD1
60
In ARPKD there are ___ in both kidneys and ___ insufficiency
Cyst Renal
61
There is only one kidney affected in \_\_\_\_
Multicystic Dysplastic Kidney Disease
62
There is no ____ parenchyma in Multicystic Dysplastic Kidney Disease
Cortical
63
The cysts in Multicystic Dysplastic Kidney Disease are made from.....
Dilations of Loop of Henle
64
\_\_\_\_ remnants of epithelial lining that become infected and enlarged
Urachal Cyst
65
\_\_\_\_ is when the end of the urachus opens to bladder (inferor) or umbilicus (Superior)
Urachal Sinus
66
Describe Urachal Fistula
Patent Uraches that allows urine to escape from umbilical orifice
67