Kruse

Question 1

Somatic NS uses what NT and what receptor

Answer 1

ACh

nAChR

Question 2

Location of nAChR - Unique

Answer 2

Adrenal Medulla (Nn)

Question 3

Function of nAChR (ionotropic)

Answer 3

1) Excitatory

2) Release of Catecholamines

Question 4

Agonists for nAChR receptors

Answer 4

ACh

Nicotine

Question 5

Location of mAChR (metabotropic) - Unique

Answer 5

Sweat Glands

Question 6

Function of mAChR

Answer 6

1) Excitatory and Inhibitory

2) Sweat Secretion

Question 7

Agonist for mAChR

Answer 7

Acetylcholine

Muscarine

Question 8

Which Muscarinic Receptors use Gi and which use Gq

Answer 8

M1,3,5 - Gq

M2,4 - Gi

Question 9

Where does Dopamine synthesis occur

Answer 9

Cytoplasm

Question 10

What is Dopamine synthesized from

Answer 10

Tyrosine

Question 11

Where does Epinephrine and Norepinephrine synthesis occur

Answer 11

Vesicle

Question 12

Conversion from NE to Epi occurs in where

Answer 12

Adrenal Medulla

Question 13

How is Tyrosine transported into the nerve terminal for synthesis for other NTs

Answer 13

Na+-dependent tyrosine transporter

Question 14

How is NE, Epi, DA, and serotonin transported into vesicles

Answer 14

Vesicular Monoamine Transporter (VMAT-2)

Question 15

How is NE and DA reuptake into the nerve terminal

Answer 15

1) NE Transporter (NET

2) DAT

Question 16

What is the fate of catecholamine after they are reuptaken?

Answer 16

Stored in vesicles via VMAT-2

Question 17

List the two main enzymes that breakdown Catecholamines

Answer 17

1) Monoamine Oxidase (MAO)

2) Catechol-O- methyltransferase (COMT)

Question 18

Rule of thumb B2 receptors Function

Answer 18

Relax smooth muscle - vasodilation

Question 19

Rule of thumb for alpha-1 receptors

Answer 19

Smooth muscle contraction and vasoconstriction

Question 20

Muscarinic receptor Rule of Thumb Function

Answer 20

Contract Smooth Muscle

Question 21

Alpha 1 receptors use G___

Answer 21

Gq

Question 22

A2 Receptors use G__

Answer 22

Gi

Question 23

All the Beta Receptors use G___

Answer 23

Gs

Question 24

Since Parasymp. dont innervate smooth muscle on vasculature, how can they influence vasodialtion.

Answer 24

1) Innervates Endothelium
2) Endothelium release NO
3) Vasodilation of SM

Question 25

What are Cholinomimetic Agents

Answer 25

Drugs that mimic ACh

Question 26

What are Cholinoceptor-Blocking Drugs

Answer 26

Drugs that mimic ACh

Question 27

List 2 types of Cholinomimetic Agents

Answer 27

AChR Agonists

Acetaylcolineseterase Inhibitors

Question 28

List a Cholinoceptor-blocking drugs

Answer 28

AChR antagonists