Renal Drugs

Question 1

MOA of Thiazide

Answer 1

1) Inhibits Na/Cl co-transporter in the distal convoluted tubule of the kidney
2) Decreases the excretion of Ca

Question 2

Adverse Reactions of Thiazides

Answer 2

1) Hyponatremia

2) Hypercalcemia

Question 3

What are the added benefits of hydrochlorothiazied in regards to Calcium metabolism?

Answer 3

1) Causes an increased absorption of Ca in the distal convoluted tubules
2) Reduces risk of renal stones

Question 4

MOA of Furosomide

Answer 4

1) Blocks the Na/2Cl/K Exchanger in the thin ascending loop of henle

Question 5

MOA of Mannitol

Answer 5

Osmotic diuretic

Question 6

MOA of acetazolamide

Answer 6

1) Carbonic anhydrase inhibitor

Question 7

Toxicity of acetazolamide

Answer 7

1) Metabolic acidosis

Question 8

Uses of acetazolamide

Answer 8

1) Glaucoma
2) Urinary alkalinization
3) Metabolic alkalosis
4) Altitude sickness
5) Pseudotumor cerebri

Question 9

Toxicity of Furosomide

Answer 9

Think OH DANG

1) Ototoxicity
2) Hypokalemia
3) Dehydration
4) Allergy
5) Nephritis
6) Gout

Question 10

Clinical use of Thiazides

Answer 10

1) Nephrogenic diabetes insipidus
2) Hypercalciuria
3) Hypertension

Question 11

Toxicity of Thiazides

Answer 11

Think: hyperGLUC

1) Hyperglycemia
2) Hyperlipidemia
3) Hyperuricemia
4) Hypercalcemia

Question 12

Spironolactone
Tramterene
Amiloride

Answer 12

K sparing diuretics

Question 13

K sparing Competitive aldosterone receptor antagonist

Answer 13

1) Spironolactone

2) Eplerenone