Renal Disease Flashcards
Deposition of immune complexes, formed in conjunction with group A Streptococcus infection, on the glomerular membrane
Acute Glomerulonephritis
Deposition of immune complexes from systemic immune disorders (systemic lupus erythematosus (SLE)) on the glomerular membrane
Rapidly Progressive (Crescentic) Glomerulonephritis
Attachment of a cytotoxic autoantibody (antiglomerular basement membrane antibody) formed during viral respiratory infections to glomerular and alveolar basement membranes
Goodpasture Syndrome
Antineutrophilic cytoplasmic autoantibody (ANCA) binds to neutrophils in vascular walls resulting to granuloma formation and damage to small vessels in the lungs and glomerulus
Wegener Granulomatosis
Occurs primarily in children following viral respiratory infections; a decrease in platelets disrupts vascular integrity
Henoch-Schönlein Purpura
Thickening of the glomerular membrane following IgG immune complex deposition associated with systemic disorders
Membranous Glomerulonephritis
Increased cellularity in the subendothelial cells of the mesangium (interstitial area of Bowman’s capsule), causing thickening of the capillary walls
Type 1 Membranoproliferative Glomerulonephritis (MPGN)
Extremely dense deposits in the glomerular basement membrane
Type 2 Membranoproliferative Glomerulonephritis (MPGN)
Marked decrease in renal function resulting from glomerular damage precipitated by other renal disorders
Chronic Glomerulonephritis
Deposition of IgA on the glomerular membrane resulting from increased levels of serum IgA
Immunoglobulin A Nephropathy (Berger’s Disease)
Most common cause of glomerulonephritis
Immunoglobulin A Nephropathy (Berger’s Disease)
Disruption of the shield of negativity and damage to the tightly fitting podocyte barrier resulting in massive loss of high-molecular-weight proteins and lipids and negatively charged albumin into the urine
Nephrotic Syndrome
Damage to the podocytes and the shield of negativity, allowing for increased protein filtration
Allergic reactions, recent immunization, and possession of the human leukocyte antigen-B12 (HLA-B12) antigen have been associated with this disease
Minimal Change Disease
Disruption of podocytes in certain areas of glomeruli (other areas remain normal) associated with heroin and analgesic abuse and AIDS
Focal Segmental Glomerulosclerosis (FSGS)
Inherited disorder of collagen production resulting to lamellated and thinning glomerular basement membrane
Alport Syndrome
Most common cause of ESRD
Diabetic Nephropathy (Kimmelstiel-Wilson Disease)
Deposition of glycosylated proteins on the glomerular basement membranes caused by poorly controlled blood glucose levels
Diabetic Nephropathy (Kimmelstiel-Wilson Disease)
The vascular structure of the glomerulus also develops sclerosis
Diabetic Nephropathy (Kimmelstiel-Wilson Disease)
Damage to renal tubular cells caused by ischemia (shock, anaphylaxis) or nephrotoxic agents
Acute Tubular Necrosis (ATN)