Renal Clearance

Question 1

Renal clearance

Answer 1

A substance is the volume of plasma completely cleared of a substance min by the kidneys

Question 2

Renal clearance equation

Answer 2

((Urine conc. of substance S)(Urine flow rate))/ (Plasma concentration of Substance S)

Question 3

Which substances are used to measure renal clearance?

Answer 3

Inulin

Creatinine

Question 4

Which substances are used to measure renal blood flow?

Answer 4

PAH (paraaminohippurate)

Question 5

Which substances are neither reabsorbed or secreted?

Answer 5

Inulin, 125 I-iothalamate, creatine

NOTE: For a substance that is freely filtered, but not reabsorbed or secreted.

Question 6

Theoretically, if a substance is completely cleared from the plasma, its clearance rate would equal ___________.

Answer 6

Renal plasma flow

Question 7

______________ is freely filtered and secreted and is almost completely cleared from the renal plasma.

Answer 7

PAH

Question 8

What are the parameters to compute clearance of a solute X?

Answer 8

• Concentration of X in the urine
• The volume of urine formed in a given time
• The concentration of X in systemic blood plasma

Question 9

Renal Handling of Four Typical Substances

Answer 9