Renal and Hepatic Flashcards
Does Renal excretion eliminate drugs
no
Is renal disease reversible
yes if caught early enough
What are the 3 components of the kidney
Pre renal - before kidney, low BP low blood volume
Renal- tumours, actions of drugs, chemotherapy
post renal - stones, ascending back pressure, infection
What are the causes of pre renal failure
Hypovolemia, low cardiac output, solute depletion, sepsis
What are the renal causes
Tubular necrosis, interstitial nephritis, acute glomerulonephritis, renal graft rejection
Can tubular necrosis be treated
Reversible if treated
What are post renal causes
Obstruction, bladder stones, bladder cancer
What is the best way to measure renal clearance
Creatinine
cockford gault calculation
What do you do in all prescribing
Start low go slow
Avoid modified release
What type of drug do you avoid in hepatic failure
Modified release due to toxicity and excretion
Which diabetic drug is modified release
Metformin
What are the four main functions of the liver
Metabolism
Synthesis - clotting factors, albumin, plasma proteins
Storage - glycogen, iron
Detoxification
What are the factors of liver dysfunction
Jaundice- bilirubin, fat soluble
unstable blood sugars
impaired absorption
low plasma proteins - ascites
What are the causes for liver disease
ETOH
cancer
fatty liver
drugs
ETOH
What are the causes for liver disease
ETOH
cancer
fatty liver
drugs
ETOH
