ANS Flashcards

1
Q

What is the Autonomic nervous system

A

Control centre in body therefore processes pharmalogical targets

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2
Q

Two types of cells

A

Neurones - convey message

Neuralgia - support and protect

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3
Q

What are neurones

A

Neurones form nerves

Unequal k+ and Na+ lead to different electrical charge
Membrane of resting potential

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4
Q

What is action potential in nerves cells

A

Neurone > Axon > away from body

Nerves fire -> depolarised

Active - Depolarised (cell is positive)
Non active - polarised (cell is negative)

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5
Q

Action potential

A

Na+ rush in
Flips the charge (depolarised)
K+ floods out
Charge flips
Na+ and K+ pumps work for it go back to normal

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6
Q

What is Saltatory conduction

A

Occurs in myelinated nerves
Increases conductivity velocity
Impulse jumps from nodes of ranvier

Speed -distance travel per unit time

Velocity - distance per unit time and direction

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7
Q

Speed of nerve impulses rely on

A

Size and type of nerve

Large mylelinated -A fibres, fast motor, sharp stabbing acute - pain

Small unmyelinated- C fibres, slow, achy throbbing pain

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8
Q

How many groups of transmitters are there

A

Biogenic amines
Amino acids
Peptides
Other

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9
Q

What is antidromic conduction

A

Conduction back tracks
urticaria causes red patches/ hive

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10
Q

What is a synapse

A

a junction between two nerve cells, impulses pass by diffusion of a neurotransmitter
frequency nerve impulse-neuro transmitter-vesicle release

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11
Q

What is the autonomic nervous system

A

Principally efferent system transmitting impulses
CNS- Peripheral organ system
Parasympathetic- steady and slow
sympathetic= fight or flight

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12
Q

What are the main characteristics of the PNS

A

Long - pre ganglionic fibres
Short- post ganglionic fibres
neurotransmitter is acetocholine
Responsible for cholinergic transmission
the ligand is cholinergic it can produce alter or release ACH

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13
Q

What are the characteristics of the Nervous system

A

fight or flight
A+B responses
neurotransmitter ACH- pre ganglionic- norad- post

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14
Q

Summary

A

ANS responsible for homeostasis
involuntary control
parasympathetic and sympathetic
Parasympathetic - conserves energy
Sympathetic- fight or flight

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15
Q

Summary 2

A

ACH through parasympathetic
ACH preganglionic + Norad
Nicotinic and muscarinic receptors in parasympathetic
A+b receptor in sympathetic

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16
Q

What is responsible for parasympathetic division

A

Cholinergic transmitters
ACH neurotransmitters
nicotinic and muscarinic receptors
ligand is acetocholine

17
Q

Nicotinic and muscarinic belong to what receptors

A

Cholinergic

18
Q

What do nictinic receptors do

A

Nachr
activate agonists - nicotine, suxamethonium - short acting
Antagonist - Tubocurine- non depolarising, long acting, reversible

19
Q

ACH is the ligand for Nachr true or false

A

True

20
Q

What are the main muscarinic receptors

A

M2 - cardiac
m3 - smooth muscle

21
Q

what is the role of M3 smooth muscle

A

Binds to acetocholine
down signalling
phospholipase

22
Q

Sympathetic nervous system is

A

2 main receptors Alpha and beta
G protein coupled

23
Q

What is the beta adreno receptor

A

inhibitory
crosses the cell 7 times

24
Q

what are muscarinic agents

A

Agonist- carbechol - allows the bladder to open
Antagonist - Atropine, hyoscine, ipratropium
Ligand - Agonist ACH