Adverse Drug Reactions

Question 1

What is the definition of ADRs

Answer 1

A response to a medicinal product which is noxious and unintended
This can be through normal use of medicine but also a result of misuse, abuse or medication error

European Medicines Agency

Question 2

What is Iatrogenic

Answer 2

Putting in a CVC and patient suffering a pneumothorax

Question 3

What is drug induced ADR

Answer 3

Renal failure

Question 4

What is a type A drug reaction

Answer 4

A predicated reaction
Dose dependent
Relatively frequent

80% of all ADRs

Question 5

What is an example of a type A reaction

Answer 5

Dry mouth with tetracyclines
Drowsiness with opioids
First dose hypotension

Question 6

What is a type B ADR

Answer 6

Not predictable - patient genes
Difficult to prevent
Rare

Not dose dependent

20% of all ADRs

Question 7

What is a type B example of ADR

Answer 7

Agranulocytosis with clozapine

Question 8

How are ADRs reported

Answer 8

Yellow card to MhRA
Green card for pharmacology

Black triangle means newly licensed, stays in Black triangle for 5 years